Methyl 4-[4-[[4-[4-(2-hydroxyethyl)piperazin-1-yl]-1,1-dioxo-1,2-thiazolidin-2-yl]methyl]triazol-1-yl]butanoate | 1333143-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Methyl 4-[4-[[4-[4-(2-hydroxyethyl)piperazin-1-yl]-1,1-dioxo-1,2-thiazolidin-2-yl]methyl]triazol-1-yl]butanoate
• CAS: 1333143-22-8
• 化学式: C₁₇H₃₀N₆O₅S
• 分子量: 430.528
• InChiKey: GUEPTIMBWUKLCS-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  N-羟乙基哌嗪 、 C₁₁H₁₆N₄O₄S 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙醇 为溶剂， 反应 10.0h， 生成 Methyl 4-[4-[[4-[4-(2-hydroxyethyl)piperazin-1-yl]-1,1-dioxo-1,2-thiazolidin-2-yl]methyl]triazol-1-yl]butanoate
  参考文献：
  名称：

  Triazole-Containing Isothiazolidine 1,1-Dioxide Library Synthesis: One-Pot, Multi-Component Protocols for Small Molecular Probe Discovery

  摘要：

  The construction of two libraries of triazole-containing isothiazolidine 1,1-dioxides is reported utilizing either a one-pot click/aza-Michael or click/OACC esterification protocol. One core dihydroisothiazole 1,1-dioxide scaffold was prepared rapidly on multigram scale via ring-closing metathesis (RCM) and was subjected to a one-pot multicomponent click/aza-Michael protocol with an array of amines and azides for the generation of a 180-member triazole-containing isothiazolidine 1,1-dioxide library. Alternatively; three daughter scaffolds were generated via the aza-Michael Of three, amino alcohols, followed by a one-pot, multicomponent dick/esterification protocol utilizing a ring-opening metathesis polymerization (ROMP)-derived coupling reagent, oligomeric alkyl carbodiimide (OACC) to generate a 41-member library of triazole-Containing isothiazole 1,1-dioxides.

  DOI：

  10.1021/co200093c