N’¹,N’¹²-bis(4,5-dihydro-1H-imidazol-2-yl)dodecanedihydrazide | 1433045-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: N’¹,N’¹²-bis(4,5-dihydro-1H-imidazol-2-yl)dodecanedihydrazide
• 英文别名: 1-N',12-N'-bis(4,5-dihydro-1H-imidazol-2-yl)dodecanedihydrazide
• CAS: 1433045-02-3
• 化学式: C₁₈H₃₄N₈O₂
• 分子量: 394.52
• InChiKey: CRWIQCTZMWAPAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  28
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  131
• 氢给体数：
  6
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  癸基二酰二氯 、 4,5-二氰咪唑-2-肼溴化氢 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以15.5%的产率得到N’¹,N’¹²-bis(4,5-dihydro-1H-imidazol-2-yl)dodecanedihydrazide
  参考文献：
  名称：

  一些双药型C2-对称衍生物的合成、化学性质和生物学评价

  摘要：

  We describe the synthesis and chemical properties of newly designed C-2-symmetrical twin-drug type aminoguanidines or 4-aminomethyloxazolidinone derivatives (4-7) in which a long chain alkyl group [-(CH2)(10)-] was used as a linker. Synthesis of some triplet-drug type symmetrical oxazolidinones (8) is also described. Among the tested compounds, the aminoguanidine derivative 4a showed the highest alpha-glucosidase inhibition activity (IC50 = 76.3 mu mol/L).

  DOI：

  10.3987/com-12-12654

文献信息

• Synthesis, Chemical Properties, and Biological Evaluations of Some Twin-Drug Type C2-Symmetrical Derivatives
  作者：Kunihiro Sumoto、Fumiko Fujisaki、Haruka Usami、Saya Nakashima、Sho Nishida、Toshihiro Fujioka、Nobuhiro Kashige、Fumio Miake

  DOI：10.3987/com-12-12654

  日期：——

  We describe the synthesis and chemical properties of newly designed C-2-symmetrical twin-drug type aminoguanidines or 4-aminomethyloxazolidinone derivatives (4-7) in which a long chain alkyl group [-(CH2)(10)-] was used as a linker. Synthesis of some triplet-drug type symmetrical oxazolidinones (8) is also described. Among the tested compounds, the aminoguanidine derivative 4a showed the highest alpha-glucosidase inhibition activity (IC50 = 76.3 mu mol/L).