2-Azabicyclo[2.2.1]heptan-1-ylmethanol | 1785333-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Azabicyclo[2.2.1]heptan-1-ylmethanol
• CAS: 1785333-54-1
• 化学式: C₇H₁₃NO
• 分子量: 127.18
• InChiKey: FNUPMUAERHXXKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Bicyclic 1,3-aminoalcohols, d8-metal complexes and hydrogenation processes
  申请人：Solvias AG

  公开号：EP1132372A2

  公开（公告）日：2001-09-12

  Bicyclic amino alcohols, whose amino group and hydroxy group are bonded in positions 1,3 adjacent to the bridge, for example are valuable ligands for metal complexes of the d-8 metals of the periodic table of elements. The metal complexes in question are catalysts or catalyst precursors for the asymmetric hydrogenation or asymmetric transfer hydrogenation with hydrogen donors of prochiral organic compounds with carbon double bonds or carbon/hetero atom double bonds, for example ketones and imines.

  例如，双环氨基醇，其氨基和羟基键合在邻近桥的 1、3 位上，是元素周期表中 d-8 金属络合物的重要配体。 是元素周期表中 d-8 金属的金属络合物的重要配体。这些金属络合物是催化剂或催化剂前体，用于具有碳双键或碳/异原子双键的手性有机化合物（例如酮和亚胺）的不对称氢化或不对称转移氢化。
• 3,5-Dioxa-8-aza-tricyclo(5.2.1.00,0)decane-9-methanols, their metal complexes and enantioselective hydrogenation processes
  申请人：Solvias AG

  公开号：EP1146047A1

  公开（公告）日：2001-10-17

  Compounds of the formula I, in the form of their racemates, mixtures of stereoisomers or mainly pure stereoisomers in which Y is C1-C4alkylene or -SiR1R2-; X is a carbon atom and A1 and A2 independently of one another are hydrogen, C1-C12alkyl, C2-C12alkenyl, C3-C8cycloalkyl, C3-C8cycloalkenyl, C3-C8cycloalkyl-C1-C4alkyl, C3-C8cycloalkenyl-C1-C4alkyl, C6-C10aryl or C7-C14aralkyl; or X is a silicon atom and A1 and A2 independently of one another are C1-C12alkyl, C3-C8cycloalkyl, C3-C8cycloalkyl-C1-C4alkyl, C6-C10aryl or C7-C14aralkyl; A3 and A4 independently of one another are hydrogen, C1-C12alkyl, C3-C8cycloalkyl, C3-C8-cycloalkyl-C1-C4alkyl, C6-C10aryl or C7-C14aralkyl; and R1 and R2 independently of one another are C1-C6alkyl, cyclohexyl, phenyl or benzyl, are ligands for metal complexes of the eighth sub-group of the Periodic Table of the Elements, which are suitable as catalysts for asymmetric hydrogenations and transfer hydrogenations of prochiral compounds having carbon/carbon or carbon/heteroatom multiple bonds.

  外消旋体、立体异构体混合物或主要是纯立体异构体形式的式 I 化合物 其中 Y 是 C1-C4 烷基或-SiR1R2-； X 是碳原子，且 A1 和 A2 独立地为氢、C1-C12 烷基、C2-C12 烯基、C3-C8 环烷基、C3-C8 环烯基、C3-C8 环烷基-C1-C4 烷基、C3-C8 环烯基-C1-C4 烷基、C6-C10 芳基或 C7-C14 芳基；或 X 为硅原子，且 A1 和 A2 各自为 C1-C12 烷基、C3-C8 环烷基、C3-C8 环烷基-C1-C4 烷基、C6-C10 芳基或 C7-C14 芳基； A3 和 A4 各自独立地为氢、C1-C12 烷基、C3-C8 环烷基、C3-C8-环烷基-C1-C4 烷基、C6-C10 芳基或 C7-C14 芳基；以及 R1 和 R2 相互独立地为 C1-C6 烷基、环己基、苯基或苄基、 是元素周期表第八亚族金属配合物的配体，适用于具有碳/碳或碳/外原子多键的手性化合物的不对称氢化和转移氢化的催化剂。
• MUSCARINIC RECEPTOR ANTAGONISTS
  申请人：Pfizer Limited

  公开号：EP0510129A1

  公开（公告）日：1992-10-28
• US5397800A
  申请人：——

  公开号：US5397800A

  公开（公告）日：1995-03-14
• [EN] MUSCARINIC RECEPTOR ANTAGONISTS
  申请人：——

  公开号：WO1992005172A2

  公开（公告）日：1992-04-02

  [EN] Muscarinic receptor antagonists, useful especially in the treatment of irritable bowel syndrome, of formula (IA) or (IB) or a pharmaceutically acceptable salt thereof, where R<2> and R<3> are each independently H, halo or C1-C4 alkyl; m is 0, 1 or 2; n is 1, 2 or 3; Y is a direct link, O or S; with the proviso that when n is 1, Y is a direct link; Het is a group of formula (A) or (B), where p is 0, 1 or 2, q is 1, 2 or 3, and r is 0, 1, 2 or 3, with the proviso that the sum of p, q and r is at least 3, the N atom of "Het" being attached to the group (CH2)n in formula (IA) and to the H atom in formula (IB); and R<1> is a group of formula (a), (b) or Het<1>, where R<4> and R<5> are each independently H, C1-C4 alkyl, C1-C4 alkoxy, -(CH2)tOH, halo, trifluoromethyl, cyano, -(CH2)tNR<6>R<7>, -CO(C1-C4 alkyl), -OCO(C1-C4 alkyl), CH(OH)(C1-C4 alkyl), -C(OH)(C1-C4 alkyl)2, -SO2NH2, -(CH2)tCONR<6>R<7> or -(CH2)tCOO(C1-C4 alkyl); R<6> and R<7> are each independently H or C1-C4 alkyl; t is 0, 1 or 2; X and X<1> are each independently O or CH2; s is 1, 2 or 3; and Het<1> is pyridyl, pyrazinyl or thienyl.
  [FR] Antagonistes de récepteurs muscariniques, spécialement efficaces pour le traitement du syndrome d'irritation intestinale, de la formule (IA) ou (IB) ou un de ses sels acceptables sur le plan pharmaceutique; dans la formule, R2 et R3 sont chacun indépendamment H, halo ou C1-C4 alkyle; m est 0, 1 ou 2; n est 1, 2 ou 3; Y est une liaison directe, O ou S; à condition que, quand n est 1, Y soit une liaison directe; Het est un groupe de formule (A) ou (B) dans laquelle p est 0, 1 ou 2, q est 1, 2 ou 3 et r est 0, 1, 2 ou 3, à condition que la somme de p, q et r soit au moins 3, l'atome N de "Het" étant attaché au groupe (CH2)n dans la formule (IA) et à l'atome H dans la formule (IB); et R1 représente un groupe de formule (a), (b) ou Het1, où R4 et R5 sont chacun indépendamment H, C1-C4 alkyle, C1-C4 alcoxy, -(CH2tOH, halo, trifluorométhyle, cyano, -(CH2)tNR6R7, -CO(C1-C4 alkyle), -OCO(C1-C4 alkyle), -CH(OH)(C1-C4 alkyle), -C(OH)(C1-C4 alkyle)2, -SO2NH2, -CH2)tCONR6R7 ou -(CH2)tCOO(C1-C4 alkyle); R6 et R7 sont chacun indépendamment H ou C1-C4 alkyle; t est 0, 1 ou 2; X et X1 sont chacun indépendamment 0 ou CH2; s est 1, 2 ou 3; et Het1 représente pyridyle, pyrazinyle ou thiényle.