N-Sulfamoyl-N'-(o-chlorphenyl)-piperazin | 29604-17-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-Sulfamoyl-N'-(o-chlorphenyl)-piperazin
• 英文别名: 4-(2-chloro-phenyl)-piperazine-1-sulfonic acid amide；4-(2-Chlorophenyl)piperazine-1-sulfonamide
• CAS: 29604-17-9
• 化学式: C₁₀H₁₄ClN₃O₂S
• mdl: MFCD11205201
• 分子量: 275.759
• InChiKey: LEZCTXCXZDXCHF-UHFFFAOYSA-N

物化性质

• 沸点：
  455.8±55.0 °C(Predicted)
• 密度：
  1.49±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  75
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions
  申请人：Antel Jochen

  公开号：US20050261292A1

  公开（公告）日：2005-11-24

  The present invention relates to the use of known and novel N-sulfamoyl-N′-arylpiperazines corresponding to Formula I and their physiologically compatible acid addition salts for the treatment or inhibition of obesity and related conditions.

  本发明涉及利用已知和新颖的对应于式I的N-磺酰基-N'-芳基哌嗪及其生理兼容性酸盐，用于治疗或抑制肥胖及相关疾病的用途。
• N-Sulfamoyl-piperidineamides for the treatment or inhibition of obesity and related conditions
  申请人：Antel Jochen

  公开号：US20070149512A1

  公开（公告）日：2007-06-28

  The present invention relates to novel N-sulfamoyl-piperidineamides of Formula I and their physiologically acceptable acid addition salts, to pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment of obesity and its concomitant and/or secondary diseases and related or other conditions.

  本发明涉及具有化学式I的新型N-磺胺基哌啶酰胺及其生理上可接受的酸盐，包括含有它们的药物组合物，其制备方法，以及用于治疗肥胖及其伴随和/或继发疾病以及相关或其他病症的用途。
• N-sulfamoyl-N'-benzopyranpiperidine compounds and uses thereof
  申请人：Antel Jochen

  公开号：US20070117823A1

  公开（公告）日：2007-05-24

  N-sulfamoyl-N′-benzopyranpiperidine compounds of formula I and their physiologically acceptable acid addition salts, pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment and/or inhibition of glaucoma, epilepsy, bipolar disorders, migraine, neuropathic pain, obesity, type II diabetes, metabolic syndrome, alcohol dependence, and/or cancer, and related concomitant and/or secondary diseases or conditions.

  式I的N-磺胺基-N'-苯并吡啶啉化合物及其生理上可接受的酸盐，包含它们的药物组合物，其制备方法，以及它们用于治疗和/或抑制青光眼、癫痫、双相情感障碍、偏头痛、神经痛、肥胖症、2型糖尿病、代谢综合征、酒精依赖症和/或癌症的用途，以及相关的并发和/或继发疾病或症状。
• MEDICAMENTS CONTAINING N-SULFAMOYL-N'-ARYLPIPERAZINES FOR THE PROPHYLAXIS OR TREATMENT OF OBESITY AND RELATED CONDITIONS
  申请人：Solvay Pharmaceuticals GmbH

  公开号：EP1750712A2

  公开（公告）日：2007-02-14
• N-SULFAMOYL-N -BENZOPYRANPIPERIDINES AS INHBITORS OF CARBONIC ANHYDRASES
  申请人：Abbott Products GmbH

  公开号：EP1951725B1

  公开（公告）日：2010-11-03