1,3-dibutyl-tetrahydro-pyrimidine-2-thione | 41469-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,3-dibutyl-tetrahydro-pyrimidine-2-thione
• 英文别名: 1,3-Dibutyl-tetrahydro-pyrimidin-2-thion；1,3-Dibutyl-1,3-diazinane-2-thione
• CAS: 41469-14-1
• 化学式: C₁₂H₂₄N₂S
• 分子量: 228.402
• InChiKey: KEHQIPRMYDCEEF-UHFFFAOYSA-N

物化性质

• 沸点：
  177-178 °C(Press: 3 Torr)
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  38.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-butyl-N-(3-butylamino-propyl)-formamide 在 sulfur 作用下， 生成 1,3-dibutyl-tetrahydro-pyrimidine-2-thione
  参考文献：
  名称：

  Effects of a 6-Week Hypocaloric Diet on Changes in Body Composition, Hunger, and Subsequent Weight Regain in Healthy Young and Older Adults

  摘要：

  Recent studies have suggested a short-term impairment in the regulation of food intake in older adults, but further studies are needed to determine if a Longer-term impairment exists and to identify underlying causes. Changes in body weight and composition were measured over a 6-week underfeeding study and a G-month follow-up period in healthy young (n = 23) and older (OLD, n = 18) men and women. The young adults were either normal weight (YNW, n = 12) or overweight (YOW, n = 11). Energy intakes during underfeeding were 896 +/- 18 (SEM) keal less than weight-maintenance energy requirements determined prior to underfeeding. In addition, changes in perceived hunger during underfeeding were monitored in a subgroup (n = 19). OLD and YOW subjects lust significantly more weight during underfeeding than did YNW subjects (p =.025 and .000, respectively), and they did not gain back significant weight in the 6-month follow-up. In addition, OLD subjects reported a significantly lower frequency of hunger during underfeeding (p, =.05). There was no significant difference among groups in the relationship between rr-eight lost and fat-free mass test. Wealthy OLD adults have an impaired ability to regulate food intake over at least 6 months following underfeeding compared with YNW adults, and a reduction in their perceived frequency of hunger may be a contributing factor.

  DOI：

  10.1093/gerona/55.12.b580