dl-catechol pentabenzoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: dl-catechol pentabenzoate
• 英文别名: dl-Catechin-pentabenzoat；[5,7-dibenzoyloxy-2-(3,4-dibenzoyloxyphenyl)-3,4-dihydro-2H-chromen-3-yl] benzoate
• 化学式: C₅₀H₃₄O₁₁
• 分子量: 810.813
• InChiKey: RFKGHGMSJVVYTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.7
• 重原子数：
  61
• 可旋转键数：
  16
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  141
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  苯甲酰氯 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 作用下， 生成 dl-catechol pentabenzoate
  参考文献：
  名称：

  Freudenberg; Purrmann, Justus Liebigs Annalen der Chemie, 1924, vol. 437, p. 276

  摘要：

  DOI：

文献信息

• Perkin; Yoshitake, Journal of the Chemical Society, 1902, vol. 81, p. 1171
  作者：Perkin、Yoshitake

  DOI：——

  日期：——
• Methods and compositions for treating metabolic disorders
  申请人：Mootha Vamsi Krishna

  公开号：US20090143279A1

  公开（公告）日：2009-06-04

  The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment metabolic diseases and neurodegenerative diseases. The methods are also useful to increase oxidative phosphorylation or to decrease reactive oxygen species (ROS) production in a subject in need thereof.
• DISSOLUTION OF AMYLOID FIBRILS BY FLAVONOIDS AND OTHER COMPOUNDS
  申请人：Eisenberg David S.

  公开号：US20100048510A1

  公开（公告）日：2010-02-25

  Methods for disrupting amyloid fibrils in a subject, comprising combining an effective amount of a β-2 microglobulin fibril disrupting compound with a medium associated with the subject, are disclosed. The invention also relates to combining the β-2 microglobulin fibril disrupting compound ex vivo with the blood during dialysis treatment of an animal. It also relates to methods for determining which compounds are effective at disrupting amyloid fibrils in a medium.
• US9463195B2
  申请人：——

  公开号：US9463195B2

  公开（公告）日：2016-10-11
• [EN] DISSOLUTION OF AMYLOID FIBRILS BY FLAVONOIDS AND OTHER COMPOUNDS<br/>[FR] DISSOLUTION DE FIBRILLES D'AMYLOÏDE PAR DES FLAVONOÏDES ET D'AUTRES COMPOSÉS
  申请人：UNIV CALIFORNIA

  公开号：WO2008076351A2

  公开（公告）日：2008-06-26

  [EN] Methods for disrupting amyloid fibrils in a subject, comprising combining an effective amount of a ß-2 microglobulin fibril disrupting compound with a medium associated with the subject, are disclosed. The invention also relates to combining the ß-2 microglobulin fibril disrupting compound ex vivo with the blood during dialysis treatment of an animal. It also relates to methods for determining which compounds are effective at disrupting amyloid fibrils in a medium.
  [FR] L'invention concerne des procédés d'interruption de fibrilles d'amyloïde chez un sujet, comprenant la combinaison d'une quantité efficace d'un composé d'interruption de fibrilles de b-2 microglobuline avec un milieu associé au sujet. L'invention concerne également la combinaison du composé d'interruption de fibrilles de b-2 microglobuline ex vivo avec le sang pendant un traitement de dialyse d'un animal. L'invention concerne également des procédés pour déterminer l'identité des composés efficaces pour interrompre les fibrilles d'amyloïde dans un milieu.