N-[2-(morpholin-4-yl)ethyl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl)oxy]propanamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: N-[2-(morpholin-4-yl)ethyl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl)oxy]propanamide
• 英文别名: N-(2-morpholin-4-ylethyl)-2-(2-oxo-4-phenylchromen-7-yl)oxypropanamide
• 化学式: C₂₄H₂₆N₂O₅
• 分子量: 422.5
• InChiKey: RUNJEDIDWGMGLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 4-PHENYL-COUMARIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF FOR THE TREATMENT OF CANCER
  申请人：Lead Discovery Center GmbH

  公开号：EP3598972A1

  公开（公告）日：2020-01-29

  The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

  本发明提供了新型的4-苯基香豆素衍生物，它们的制备方法和用途作为特异性线粒体RNA聚合酶抑制剂，用于治疗癌症。
• 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer
  申请人：Lead Discovery Center GmbH

  公开号：US10703735B2

  公开（公告）日：2020-07-07

  The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

  本发明提供了新型 4-苯基香豆素衍生物、其制备工艺及其作为治疗癌症的特异性线粒体 RNA 聚合酶抑制剂的用途。
• 4-PHENYL-COUMARIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF FOR THE TREATMENT OF CANCER
  申请人：Lead Discovery Center GmbH

  公开号：US20200031794A1

  公开（公告）日：2020-01-30

  The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.