[(2S,3R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [(2S,3R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate
• 英文别名: [5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate
• 化学式: C₁₈H₂₄N₉O₁₀P
• 分子量: 557.4
• InChiKey: GUWXKKAWLCENJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  271
• 氢给体数：
  6
• 氢受体数：
  11

文献信息

• Drug compound and purification methods thereof
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US10858386B2

  公开（公告）日：2020-12-08

  The invention provides a method of preparing a lyophilized pharmaceutical composition containing a compound described herein or a pharmaceutically-acceptable salt thereof. The process comprises dissolving the compound in a solvent comprising dimethylsulfoxide and optionally one or more co-solvents to form a solution, and then removing the solvent and any co-solvents by a freeze-drying process. Also provided by the invention are lyophilized pharmaceutical compositions and their use in medicine and in particular in the treatment of cancer.

  本发明提供了一种制备含有本文所述化合物或其药学上可接受的盐的冻干药物组合物的方法。该方法包括将化合物溶解在由二甲基亚砜和可选的一种或多种助溶剂组成的溶剂中形成溶液，然后通过冷冻干燥工艺除去溶剂和任何助溶剂。本发明还提供了冻干药物组合物及其在医学中的应用，特别是在癌症治疗中的应用。
• PHARMACEUTICAL COMPOSITIONS FOR TREATING EBOLA VIRUS DISEASE
  申请人：Vecht-Lifshitz, Susan Eve

  公开号：EP3200826B1

  公开（公告）日：2021-04-21
• DRUG COMPOUND AND PURIFICATION METHODS THEREOF
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US20190085018A1

  公开（公告）日：2019-03-21

  The invention provides a method of preparing a lyophilized pharmaceutical composition containing a compound described herein or a pharmaceutically-acceptable salt thereof. The process comprises dissolving the compound in a solvent comprising dimethylsulfoxide and optionally one or more co-solvents to form a solution, and then removing the solvent and any co-solvents by a freeze-drying process. Also provided by the invention are lyophilized pharmaceutical compositions and their use in medicine and in particular in the treatment of cancer.
• [EN] DRUG COMPOUND AND PURIFICATION METHODS THEREOF<br/>[FR] COMPOSÉ MÉDICAMENTEUX ET SES PROCÉDÉS DE PURIFICATION
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2019025863A2

  公开（公告）日：2019-02-07

  The invention provides a method of preparing a lyophilized pharmaceutical composition containing a compound described herein or a pharmaceutically-acceptable salt thereof. The process comprises dissolving the compound in a solvent comprising dimethylsulfoxide and optionally one or more co-solvents to form a solution, and then removing the solvent and any co-solvents by a freeze-drying process. Also provided by the invention are lyophilized pharmaceutical compositions and their use in medicine and in particular in the treatment of cancer.