9-Hydroxy-3,4-dichlorodibenzofuran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 9-Hydroxy-3,4-dichlorodibenzofuran
• 英文别名: 6,7-dichlorodibenzofuran-1-ol
• 化学式: C₁₂H₆Cl₂O₂
• 分子量: 253.08
• InChiKey: AXMITDHZDYKPEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHOD OF DETECTING ESTROGEN-LIKE SUBSTANCE BY USING PLANT
  申请人：National University Corporation Hokkaido University

  公开号：EP1790216A1

  公开（公告）日：2007-05-30

  The present invention provides a detection method of estrogen-like chemicals, which uses a plant, needs not use a complicated procedure as sterilization and is highly sensitive as a sensor. The present invention is a transformed plant, which is transformed by transducing effector 1 sequence, effector 2 sequence, a target DNA and a reporter gene, wherein said effector 1 sequence has a promoter, a nuclear localization signal, and a chimeric gene comprising a domain coding a polypeptide binding to a target DNA and a domain coding a ligand binding polypeptide of intranuclear receptors for estrogen-like chemicals, said effector 2 sequence has a promoter, a nuclear localization signal, and a chimeric gene comprising a domain coding an interacting domain with intranuclear receptors in a transcriptional coactivator and a domain coding a transcriptional activation domain, and said reporter gene locates in the down stream of said target DNA. The transformed plant is contacted with estrogen-like chemicals and the expression of the reporter gene in the plant is detected.

  本发明提供了一种雌激素类化学物质的检测方法，该方法使用植物，无需复杂的消毒程序，作为传感器灵敏度高。 本发明是一种转化植物，它是通过转入效应子 1 序列、效应子 2 序列、靶 DNA 和报告基因而转化的，其中所述效应子 1 序列具有启动子、核定位信号和嵌合基因，嵌合基因包括编码与靶 DNA 结合的多肽的结构域和编码雌激素类化学物质核内受体配体结合多肽的结构域、所述效应物 2 序列具有启动子、核定位信号和嵌合基因，嵌合基因包括编码与转录辅激活剂核内受体相互作用结构域的结构域和编码转录激活结构域的结构域，所述报告基因位于所述靶 DNA 的下游。将转化植物与雌激素类化学物质接触，检测植物中报告基因的表达情况。
• Method for Detecting Estrogen-Like Chemicals by Plant
  申请人：Yamazaki Kenichi

  公开号：US20080199858A1

  公开（公告）日：2008-08-21

  The present invention provides a detection method of estrogen-like chemicals, which uses a plant, needs not use a complicated procedure as sterilization and is highly sensitive as a sensor. The present invention is a transformed plant, which is transformed by transducing effector 1 sequence, effector 2 sequence, a target DNA and a reporter gene, wherein said effector 1 sequence has a promoter, a nuclear localization signal, and a chimeric gene comprising a domain coding a polypeptide binding to a target DNA and a domain coding a ligand binding polypeptide of intranuclear receptors for estrogen-like chemicals, said effector 2 sequence has a promoter, a nuclear localization signal, and a chimeric gene comprising a domain coding an interacting domain with intranuclear receptors in a transcriptional coactivator and a domain coding a transcriptional activation domain, and said reporter gene locates in the down stream of said target DNA. The transformed plant is contacted with estrogen-like chemicals and the expression of the reporter gene in the plant is detected.