bis-2-propenyl thiosulfonate | 29418-05-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: bis-2-propenyl thiosulfonate
• 英文别名: diallyl thiosulfonate；Pseudoallicin；S-allyl prop-2-ene-1-sulfonothioate；2-Propenylpropenthiosulfonat；prop-2-ene-1-thiosulfonic acid S-allyl ester；Prop-2-en-1-thiosulfonsaeure-S-allylester；allyl-(2-propenethio)-sulfonate；S-2-Propenyl 2-propene-1-sulfonothioate；3-prop-2-enylsulfonylsulfanylprop-1-ene
• CAS: 29418-05-1
• 化学式: C₆H₁₀O₂S₂
• 分子量: 178.276
• InChiKey: FKSYNVLOSJKCKH-UHFFFAOYSA-N

物化性质

• 沸点：
  294.3±29.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  67.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  L-半胱氨酸 、 bis-2-propenyl thiosulfonate 生成 S-allylmercapto-L-cysteine
  参考文献：
  名称：

  Belous; Postowskii, Zhurnal Obshchei Khimii, 1950, vol. 20, p. 1701,1705; engl.Ausg.S. 1761, 1765

  摘要：

  DOI：
• 作为产物：
  描述：

  二烯丙基二硫 在 盐酸 、 双氧水 作用下， 以 二氯甲烷 、 水 为溶剂， 以51 %的产率得到bis-2-propenyl thiosulfonate
  参考文献：
  名称：

  In situ generated HClO for the conversion of thiols and disulfides into thiosulfonates

  摘要：

  DOI：

  10.24820/ark.5550190.p011.922

文献信息

• Facile preparation and rearrangement of allylic dialkoxy disulfides
  作者：Samuel Braverman、Tatiana Pechenick

  DOI：10.1016/s0040-4039(01)02174-8

  日期：2002.1

  Allylic dialkoxy disulfides were obtained in good yields and their reactivity has been investigated. Similarly to allylic sulfoxylates, these esters undergo double [2,3]-sigmatropic rearrangement to the appropriate vic-disulfoxides. The latter, being unstable, undergoes spontaneous rearrangement to the corresponding thiosulfonates.

  烯丙基二烷氧基二硫化物以良好的产率获得，并且已经研究了它们的反应性。类似于烯丙基次硫酸盐，这些酯经历双[2,3] -sigmatropic重排到适当的VIC -disulfoxides。后者是不稳定的，会自发地重排为相应的硫代磺酸盐。
• Antimicrobial blood treatment using allicin and related compounds
  申请人：——

  公开号：US20030077264A1

  公开（公告）日：2003-04-24

  Methods and compositions prolonging the storage life and/or increasing the safety of a blood product, such as whole blood, red blood cells, white blood cells, platelets, serum and aqueous additive solutions for storage of such blood products are provided. Storage solutions of this invention comprise a composition selected from the group consisting of garlic extract, allicin, other microorganism-growth-inhibiting compounds derived from garlic, and analogs and derivatives of allicin and said other compounds, in an amount effective to inhibit growth of at least one selected microorganism which is a bacterium, virus, fungus or parasite. The storage additive solutions of this invention can increase platelet storage life by at least about 20%, preferably at least about 40%.

  本发明提供了一种延长血液制品（如全血、红细胞、白细胞、血小板、血清和用于储存这种血液制品的水性添加剂溶液）的储存寿命和/或提高安全性的方法和组合物。本发明的储存溶液包括从大蒜提取的化合物、大蒜素、从大蒜中提取的其他微生物生长抑制化合物以及大蒜素和该等化合物的类似物和衍生物中选择的一种组成，其有效抑制至少一种选择的细菌、病毒、真菌或寄生虫的生长。本发明的储存添加剂溶液可以将血小板的储存寿命延长至少20％，最好至少40％。
• SEMI-SOLID TOPICAL COMPOSITION WHICH CONTAINS PIRFENIDONE AND MODIFIED DIALLYL DISULPHIDE OXIDE (M-DDO) FOR ELIMINATING OR PREVENTING ACNE
  申请人：Cell Therapy and Technology S.A. de C.V.

  公开号：EP2832354A1

  公开（公告）日：2015-02-04

  The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial/antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

  本发明涉及一种半固体外用组合物，该组合物含有吡非尼酮和一种抗菌/防腐剂，如改性二烯丙基二硫氧化物（M-DDO）及其制备工艺，与现有技术中已知的其他外用给药形式相比具有优势，可用作抗纤维化、消炎和防腐剂，用于预防、治疗和逆转痤疮和痤疮后皮损。 所述组合物还可用于减轻皮肤发红，阻止新的痤疮爆发，逆转已经存在的痤疮爆发，以及修复痤疮造成的皮肤损伤。
• Semi-solid topical composition containing pirfenidone and modified diallyl disulfide oxide (M-DDO) for eliminating or preventing acne
  申请人：Excalibur Pharmaceuticals, Inc.

  公开号：US11013727B2

  公开（公告）日：2021-05-25

  The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial/antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

  本发明涉及一种半固体外用组合物，该组合物含有吡非尼酮和一种抗菌/防腐剂，如改性二烯丙基二硫氧化物（M-DDO）及其制备工艺，与现有技术中已知的其他外用给药形式相比具有优势，可用作抗纤维化、消炎和防腐剂，用于预防、治疗和逆转痤疮和痤疮后皮损。所述组合物还可用于减轻皮肤发红，阻止新的痤疮爆发，逆转已经存在的痤疮爆发，以及修复痤疮造成的皮肤损伤。
• Garlic Chemistry. Nitric Oxide Oxidation of S-2-Propenylcysteine and (+)-S-2-Propenyl-L-Cysteine Sulfoxide
  作者：Fillmore Freeman、Bao-Guo Huang、Robert I-San Lin

  DOI：10.1021/jo00090a048

  日期：1994.6