Ethyl 6-amino-3-methyl-1-benzofuran-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: Ethyl 6-amino-3-methyl-1-benzofuran-2-carboxylate
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: JFVDDWYFMNQCEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Application of ethyl p-methoxycinnamate and derivatives thereof in maintaining self-renewal and pluripotency of stem cells
  申请人：NORTHEAST NORMAL UNIVERSITY

  公开号：US10723998B2

  公开（公告）日：2020-07-28

  Disclosed is a use of ethyl p-methoxycinnamate and derivatives thereof in preparing drugs, culture media, regulating agents or cosmetic and skin caring products for maintaining self-renewal and pluripotency of stem cells. The stem cells comprise adult stem cells, embryonic stem cells and induced pluripotent stem (iPS) cells. Also disclosed is a use of ethyl p-methoxycinnamate and the derivatives thereof in in-vitro amplification of stem cells and preparation of induced pluripotent stem (iPS) cells and a use of ethyl p-methoxycinnamate and the derivatives thereof in preparing drugs for treating cell deletion or injury diseases.

  本发明公开了对甲氧基肉桂酸乙酯及其衍生物在制备药物、培养基、调节剂或美容护肤产品中的用途，用于维持干细胞的自我更新和多能性。干细胞包括成体干细胞、胚胎干细胞和诱导多能干细胞（iPS）。还公开了对甲氧基肉桂酸乙酯及其衍生物在体外扩增干细胞和制备诱导多能干（iPS）细胞中的用途，以及对甲氧基肉桂酸乙酯及其衍生物在制备治疗细胞缺失或损伤疾病药物中的用途。
• APPLICATION OF ETHYL P-METHOXYCINNAMATE AND DERIVATIVES THEREOF IN MAINTAINING SELF-RENEWAL AND PLURIPOTENCY OF STEM CELLS
  申请人：NORTHEAST NORMAL UNIVERSITY

  公开号：US20180195039A1

  公开（公告）日：2018-07-12

  Disclosed is a use of ethyl p-methoxycinnamate and derivatives thereof in preparing drugs, culture media, regulating agents or cosmetic and skin caring products for maintaining self-renewal and pluripotency of stem cells. The stem cells comprise adult stem cells, embryonic stem cells and induced pluripotent stem (iPS) cells. Also disclosed is a use of ethyl p-methoxycinnamate and the derivatives thereof in in-vitro amplification of stem cells and preparation of induced pluripotent stem (iPS) cells and a use of ethyl p-methoxycinnamate and the derivatives thereof in preparing drugs for treating cell deletion or injury diseases.