7-Phloroeckol | 662165-35-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: 7-Phloroeckol
• 英文别名: 4-(3,5-dihydroxyphenoxy)-8-(2,4,6-trihydroxyphenoxy)dibenzo-p-dioxin-1,3,6-triol
• CAS: 662165-35-7
• 化学式: C₂₄H₁₆O₁₂
• 分子量: 496.4
• InChiKey: JLEVVQRBEATTCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  199
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• 7'-PHLOROECKOL COMPOUND FOR HAIR PROLIFERATION AND A COSMETIC COMPOSITION CONTAINING SAME
  申请人：Kim Se-Kwon

  公开号：US20140039204A1

  公开（公告）日：2014-02-06

  The effects on human hair growth of 7′-phloroeckol (1-(3′,5′-dihydroxyphenoxy)-7-(2″,4″,6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin) isolated from E. cava ( Ecklonia cava ) have been studied in cell systems. The cell-proliferation and anti-apoptotic effects on human human hair follicle dermal papilla cells (HFDPC) and human keratinocytes (human epidermal keratinocytes: HaCaT) were investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and western blot. The 7′-phloroeckol significantly increased HFDPC and HaCaT proliferation. With HFDPC and HaCaT, the amount of PI3K and phosphorylated AKT protein expression increased in a way which was dependent on the extent of 7′-phloroeckol treatment. Also, the levels of MEK½, phosphorylated ERK and c-Fos proteins, which are associated with cell proliferation, increased in a way which was dependent on the extent of 7′-phloroeckol treatment. Meanwhile, apoptosis was inhibited as there was an increase in the Bcl-2/Bax ratio which is associated with apoptosis, and there was a significant reduction in p53 and also caspase-3 and caspase-9. These results indicate that 7′-phloroeckol can promote human hair growth by inhibiting apoptosis and stimulating HFDPC and HaCaT proliferation.
• [EN] 7'-PHLOROECKOL COMPOUND FOR HAIR PROLIFERATION AND A COSMETIC COMPOSITION CONTAINING SAME<br/>[FR] COMPOSÉ DE 7'-PHLOROECKOL POUR PROLIFÉRATION DE CHEVEUX ET COMPOSITION COSMÉTIQUE LE CONTENANT
  申请人：NAT UNIV PUKYONG IND UNIV COOP

  公开号：WO2012093752A1

  公开（公告）日：2012-07-12

  감태(Ecklonia cava: E. Cava)로부터 분리한 7'-플로로에콜 (1-(3',5'-다이하이드록시페녹시)-7-(2",4",6-트리하이드록시페녹시)-2,4,9-트리하이드록시다이벤조-1,4-다이옥신)이 인체 모발 성장에 대해 갖는 효과에 대하여 세포 시스템내에서 연구되었다. 세포증식 및 항세포사멸사의 효과를 3-(4,5-다이메틸티아졸-2-일)-2,5-다이페닐 테트라졸륨 브로마이드(MTT) 분석 및 웨스턴 블롯(western blot)에 의해 인체 모낭 모유두 세포(hair follicle dermal papilla cell: HFDPC) 및 인체 각질형성세포(human epidermal keratinocyte: HaCaT)에 대하여 실시하였다. 7'-플로로에콜은 HFDPC 및 HaCaT의 증식을 유의하게 증식시켰다. HFDPC와 HaCaT에서 PI3K 및 인산화-AKT 단백질 발현이 7'-플로로에콜 처리량에 의존적으로 증가하였다. 또한, 세포 증식에 관련된 MEK1/2, 인산화-ERK 및 c-Fos의 단백질 수준은 7'-플로로에콜 처리량 의존적으로 증가하였다. 한편, 세포자멸사에 관련된 Bcl-2/Bax 비가 증가하여 세포자멸사를 저해하였고, p53 및 카스파아제(caspase)-3, 카스파아제-9은 유의하게 감소하였다. 이들 결과는 7'-플로로에콜이 세포자멸사를 저해하고 HFDPC 및 HaCaT의 증식을 자극시킴으로써 인체 모발 성장을 촉진할 수 있음을 시사한다.
• [EN] COMPOUNDS, PROCESSES FOR EXTRACTING THEM FROM KELP, COMPOSITIONS CONTAINING SAID COMPOUNDS AND USE OF SAID COMPOSITIONS<br/>[FR] COMPOSÉS, PROCÉDÉS POUR EXTRAIRE CEUX-CI À PARTIR DE VARECH, COMPOSITIONS CONTENANT LESDITS COMPOSÉS ET UTILISATION DESDITES COMPOSITIONS
  申请人：LAMICARE HEALTH LTD

  公开号：WO2014132213A1

  公开（公告）日：2014-09-04

  A composition is prepared by: preparing an aqueous solution of sodium citrate and citric acid; and combining fresh kelp with the aqueous solution. The ratio between the sodium citrate and citric acid in the aqueous solution is about 10:1, by mass. The composition includes at least one of: 4-(3,5- dihydroxyphenoxy)dibenzo [b,e][1,4]dioxine-1,3,6,8-tetraol; 8-(2,4,6- trihydroxyphenoxy)-4-(3,5-dihydroxyphenoxy)dibenzo [b,e][1,4]dioxine -1,3,6- triol; 8-(2,4,6-trihydroxyphenoxy)-9-(3,5-dihydroxyphenoxy)dibenzo [1,4]dioxine-1,3,6-triol; and (8S,9S,10R, 13R,14S,17R)- 2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-17-(R,E)-5-isopropylhept-5 -en-2-yl)-10,13-demethyl-1H-cyclopenta[a]phenanthren-3-ol.

表征谱图