8-dimethylaminomethyl-7-hydroxy-4-phenyl coumarin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 8-dimethylaminomethyl-7-hydroxy-4-phenyl coumarin
• 英文别名: 8-[(dimethylamino)methyl]-7-hydroxy-4-phenyl-2H-chromen-2-one；8-[(dimethylamino)methyl]-7-hydroxy-4-phenylchromen-2-one
• 化学式: C₁₈H₁₇NO₃
• mdl: MFCD01547154
• 分子量: 295.338
• InChiKey: KNEPVOKMHZTBPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四甲基甲烷二胺 、 7-羟基-4-苯基香豆素 以 1,4-二氧六环 为溶剂， 以81%的产率得到8-dimethylaminomethyl-7-hydroxy-4-phenyl coumarin
  参考文献：
  名称：

  摘要：

  Aminomethylation of 5-hydroxy- and 7-hydroxy-4-phenylcoumarins by substituted 1, 1-dianzinomethanes is studied Mannich condensation of amino acids and their esters with 7-hydroxy-4-phenylcoumarin gives a series of 8-aminoacylmethylcoumarins and 4-phenyl-9, 10-dihydro-2H, 8H-chromeno[8, 7-e][1, 3]oxazin-2-ones.

  DOI：

  10.1023/a:1002835422747

文献信息

• Rao; Raju; Raju, Journal of the Indian Chemical Society, 1981, vol. 58, # 10, p. 1021 - 1023
  作者：Rao、Raju、Raju

  DOI：——

  日期：——
• ——
  作者：M. M. Garazd、Ya. L. Garazd、S. V. Shilin、V. P. Khilya

  DOI：10.1023/a:1002835422747

  日期：——

  Aminomethylation of 5-hydroxy- and 7-hydroxy-4-phenylcoumarins by substituted 1, 1-dianzinomethanes is studied Mannich condensation of amino acids and their esters with 7-hydroxy-4-phenylcoumarin gives a series of 8-aminoacylmethylcoumarins and 4-phenyl-9, 10-dihydro-2H, 8H-chromeno[8, 7-e][1, 3]oxazin-2-ones.