tert-butyl-[(E,6S)-6-[tert-butyl(diphenyl)silyl]oxy-9-(2-methoxyethoxymethoxy)-3-methylnon-2-en-7-ynoxy]-diphenylsilane | 1240411-70-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tert-butyl-[(E,6S)-6-[tert-butyl(diphenyl)silyl]oxy-9-(2-methoxyethoxymethoxy)-3-methylnon-2-en-7-ynoxy]-diphenylsilane
• CAS: 1240411-70-4
• 化学式: C₄₆H₆₀O₅Si₂
• 分子量: 749.15
• InChiKey: VYZOLYUYTDRSCC-FHZUEUJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.88
• 重原子数：
  53
• 可旋转键数：
  20
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl-[(E,6S)-6-[tert-butyl(diphenyl)silyl]oxy-9-(2-methoxyethoxymethoxy)-3-methylnon-2-en-7-ynoxy]-diphenylsilane 在 D(+)-10-樟脑磺酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 12.0h， 以90%的产率得到(S,E)-6-((tert-butyldiphenylsilyl)oxy)-9-((2-methoxyethoxy)methoxy)-3-methylnon-2-en-7-yn-1-ol
  参考文献：
  名称：

  Progress towards the total synthesis of 2,3-dihydroxytrinervitanes

  摘要：

  Intramolecular Diels-Alder approach to construct the fused AB ring of trinervitane has been demonstrated efficiently. The key intermediate for the Diels-Alder cyclization has been achieved following highly stereoselective Julia-Kocienski olefination, Sharp less epoxidation and Evan's asymmetric alkylation as the key reactions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.065
• 作为产物：
  描述：

  聚合甲醛 、 2-甲氧基乙氧基甲基氯 、 (S,E)-10-ethynyl-2,2,7,13,13-pentamethyl-3,3,12,12-tetraphenyl-4,11-dioxa-3,12-disilatetradec-6-ene 在 正丁基锂 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 tert-butyl-[(E,6S)-6-[tert-butyl(diphenyl)silyl]oxy-9-(2-methoxyethoxymethoxy)-3-methylnon-2-en-7-ynoxy]-diphenylsilane
  参考文献：
  名称：

  Progress towards the total synthesis of 2,3-dihydroxytrinervitanes

  摘要：

  Intramolecular Diels-Alder approach to construct the fused AB ring of trinervitane has been demonstrated efficiently. The key intermediate for the Diels-Alder cyclization has been achieved following highly stereoselective Julia-Kocienski olefination, Sharp less epoxidation and Evan's asymmetric alkylation as the key reactions. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.065

文献信息

• Progress towards the total synthesis of 2,3-dihydroxytrinervitanes
  作者：Jhillu Singh Yadav、Swapan Kumar Biswas、Sandip Sengupta

  DOI：10.1016/j.tetlet.2010.03.065

  日期：2010.8

  Intramolecular Diels-Alder approach to construct the fused AB ring of trinervitane has been demonstrated efficiently. The key intermediate for the Diels-Alder cyclization has been achieved following highly stereoselective Julia-Kocienski olefination, Sharp less epoxidation and Evan's asymmetric alkylation as the key reactions. (C) 2010 Elsevier Ltd. All rights reserved.