Fmoc-D-Biocytin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 生物素及其衍生物
• 英文名称: Fmoc-D-Biocytin
• 英文别名: 2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]hexanoic acid
• 化学式: C₃₁H₃₈N₄O₆S
• 分子量: 594.7
• InChiKey: OFIBQNGDYNGUEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  42
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  171
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Macrolide Compounds Containing Biotin and Photo-Affinity Group for Macrolide Target Identification
  申请人：Culic Ognjen

  公开号：US20080241959A1

  公开（公告）日：2008-10-02

  The present invention relates to new macrolide compounds represented by the general structure I, wherein M is a macrolide, P is a photo-affinity group bearing subunit containing biotin, and L is a linking molecule, and to their pharmaceutically acceptable salts and solvates, to processes and intermediates for their preparation and to the use of these compounds for the macrolide target identification.
• US7989600B2
  申请人：——

  公开号：US7989600B2

  公开（公告）日：2011-08-02
• [EN] STRUCTURE-BASED PEPTIDE INHIBITORS THAT TARGET THE TAU VQIINK FIBRILLIZATION SEGMENT<br/>[FR] INHIBITEURS PEPTIDIQUES À BASE DE STRUCTURE CIBLANT LE SEGMENT DE FORMATION DE FIBRILLES DE TAU VQIINK
  申请人：UNIV CALIFORNIA

  公开号：WO2018170324A1

  公开（公告）日：2018-09-20

  Aggregated Tau protein is associated with over 20 neurological disorders including Alzheimer's disease. Previous work has shown that Tau's sequence segments VQIINK and VQIVYK drive its aggregation, and that inhibitors based on the structure of the VQIVYK segment partially inhibit Tau aggregation. Here we show that the VQIINK segment is the more powerful driver of Tau aggregation. Two structures of this segment determined by the cryo EM method MicroED explain its more powerful seeding. Of practical significance, the understanding of the structures has led to the design of structure based peptide inhibitors that effectively inhibit Tau aggregation as well as the ability of exogenous Tau fibrils to seed intracellular Tau in mammalian cells into amyloid.
• [EN] PEPTIDE-BASED INHIBITORS THAT BLOCK AGGREGATION, SEEDING AND CROSS-SEEDING OF AMYLOID BETA AND TAU<br/>[FR] INHIBITEURS À BASE DE PEPTIDES QUI BLOQUENT L'AGRÉGATION, L'ENSEMENCEMENT ET L'ENSEMENCEMENT CROISÉ DE PROTÉINE BÊTA-AMYLOÏDE ET DE PROTÉINE TAU
  申请人：UNIV CALIFORNIA

  公开号：WO2020232440A1

  公开（公告）日：2020-11-19

  Alzheimer's disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles which track with cognitive decline. Here, we report peptide-based inhibitors that reduce Aβ and tau aggregation and toxicity of already-aggregated species.