.beta-Penta-O-galloyl-D-glucose

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 英文名称: .beta-Penta-O-galloyl-D-glucose
• 英文别名: [3,4,5,6-tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoate
• 化学式: C₄₁H₃₂O₂₆
• 分子量: 940.7
• InChiKey: QJYNZEYHSMRWBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  67
• 可旋转键数：
  16
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  444
• 氢给体数：
  15
• 氢受体数：
  26

文献信息

• COMBINATION OF COMPOUNDS DERIVED FROM GALLIC ACID FOR THE TREATMENT OF CANCER
  申请人：FIORENTINO Susana

  公开号：US20150313925A1

  公开（公告）日：2015-11-05

  The invention relates to a combination of compounds derived from gallic acid, with an antitumoral and antimetastatic activity via a mechanism that involves the induction of apoptosis and the immunogenic death of the tumour cells and the subsequent activation of the specific immune response. The invention also relates to a composition containing a combination of derivatives of gallic acid and pharmaceutically acceptable excipients for the production of useful medicaments in the treatment of cancer. The invention further relates to the use of said composition in a coadjuvant in conventional chemotherapy, reducing the doses of chemptherapeutic agents used in the treatment of cancer.

  该发明涉及一种由没食子酸衍生的化合物组合，具有抗肿瘤和抗转移活性，通过诱导细胞凋亡和肿瘤细胞的免疫原性死亡以及后续激活特异性免疫应答的机制。该发明还涉及一种含有没食子酸衍生物组合和药用可接受的赋形剂的组合物，用于生产用于治疗癌症的有用药物。该发明进一步涉及在常规化疗中使用该组合物作为辅助剂，减少用于癌症治疗的化疗药物的剂量。
• Methods to reduce fat accumulation and oxidative damage in liver using green mango extracts and compounds obtained therefrom
  申请人：TCI CO., LTD.

  公开号：US10918683B2

  公开（公告）日：2021-02-16

  Provided is a method for reducing fat accumulation in and oxidative damage to liver cells by using a green mango extract. Also provided is a method for reducing fat accumulation in liver cells by using compounds of hydrolyzable tannins isolated from the green mango extract.

  本发明提供了一种利用绿芒果提取物减少肝细胞脂肪积累和氧化损伤的方法。还提供了一种利用从绿芒果提取物中分离出的可水解单宁化合物减少肝细胞中脂肪积累的方法。
• Methods for skin whitening, ultraviolet radiation protection and suppression of glycation using green mango extracts and compounds obtained therefrom
  申请人：TCI CO., LTD.

  公开号：US10940174B1

  公开（公告）日：2021-03-09

  Provided is a method for skin whitening, ultraviolet radiation protection, and anti-glycation by using a green mango extract. Also provided is a method for anti-glycation by using compounds of hydrolyzable tannins isolated from the green mango extract.

  本发明提供了一种利用绿芒果提取物美白皮肤、防紫外线辐射和抗糖化的方法。还提供了一种利用从绿芒果提取物中分离出来的可水解单宁化合物抗糖化的方法。
• Compounds and pharmaceutical uses thereof
  申请人：SyneuRx International (Taiwan) Corp.

  公开号：US11154531B2

  公开（公告）日：2021-10-26

  A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

  一种治疗冠状病毒感染的方法，包括向有需要的受试者施用有效量的组合物，其中组合物包含一种或多种式（I）化合物： 或其药学上可接受的盐。
• SUPERABSORBIERENDE ZUSAMMENSETZUNG MIT TANNINEN ZUR GERUCHSKONTROLLE
  申请人：Evonik Operations GmbH

  公开号：EP2176325B1

  公开（公告）日：2021-12-08