Roseobacticide A

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环七呋喃
• 英文名称: Roseobacticide A
• 英文别名: 3-(4-hydroxyphenyl)-7-methylsulfanylcyclohepta[b]furan-2-one
• 化学式: C₃₆H₅₅N₈O₈PolS₂Si
• 分子量: 284.3
• InChiKey: VMNFBEULKIKVRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Roseobacticide A 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Native Chemical Ligation of Hydrolysis-Resistant 3′-Peptidyl–tRNA Mimics

  摘要：

  Hydrolysis-resistant 3'-peptidyl-RNA conjugates that mimic tRNA termini represent a remarkable synthetic challenge, particularly if they contain amino acids with complex side-chain functionalities, such as arginines. Here we demonstrate a novel approach that combines solid-phase synthesis and bioconjugation to obtain these derivatives with high efficiency and purity. The key step is native chemical ligation of 3'-cysteinyl-RNA fragments to highly soluble peptide thioesters. The so-prepared 3'-peptidyl-RNA conjugates relate to resistance peptides that can render the ribosome resistant to macrolide antibiotics by a yet unknown ribosomal translation mechanism.

  DOI：

  10.1021/ja209053b
• 作为产物：
  描述：

  aminomethyl-terminated Tentagel resin 、 3'-N-[N-allyloxycarbonyl-S-(tert-butylthio)-L-cysteinyl]-5'-O-(tert-butyldimethylsilyl)-N6,N6-{2-[3-oxo-3-(pentafluorophenyloxy)propyl]}glutaryl-9-(3'-amino-2',3'-dideoxy-β-D-ribofuranosyl)adenine 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 Roseobacticide A
  参考文献：
  名称：

  Native Chemical Ligation of Hydrolysis-Resistant 3′-Peptidyl–tRNA Mimics

  摘要：

  Hydrolysis-resistant 3'-peptidyl-RNA conjugates that mimic tRNA termini represent a remarkable synthetic challenge, particularly if they contain amino acids with complex side-chain functionalities, such as arginines. Here we demonstrate a novel approach that combines solid-phase synthesis and bioconjugation to obtain these derivatives with high efficiency and purity. The key step is native chemical ligation of 3'-cysteinyl-RNA fragments to highly soluble peptide thioesters. The so-prepared 3'-peptidyl-RNA conjugates relate to resistance peptides that can render the ribosome resistant to macrolide antibiotics by a yet unknown ribosomal translation mechanism.

  DOI：

  10.1021/ja209053b

文献信息

• ROSEOBACTICIDES AND USES THEREOF
  申请人：Kolter Roberto

  公开号：US20130252815A1

  公开（公告）日：2013-09-26

  Embodiments of the invention relate to compounds and methods for controlling algal growth, for example, in bodies of water or surfaces exposed to algae. Provided are compounds having algicidal activities and methods of use of these compounds as well as formulations and compositions comprising the compound having algicidal activities.

  本发明实施例涉及化合物和方法，用于控制藻类生长，例如在水体或暴露于藻类的表面中。提供了具有藻类杀灭活性的化合物以及使用这些化合物的方法，以及包含具有藻类杀灭活性的化合物的配方和组合物。
• Roseobacticides and uses thereof
  申请人：Kolter Roberto

  公开号：US09131687B2

  公开（公告）日：2015-09-15

  Embodiments of the invention relate to compounds and methods for controlling algal growth, for example, in bodies of water or surfaces exposed to algae. Provided are compounds having algicidal activities and methods of use of these compounds as well as formulations and compositions comprising the compound having algicidal activities.

  该发明的实施例涉及化合物和方法，用于控制藻类生长，例如在水体或暴露于藻类的表面中。提供具有杀藻活性的化合物以及使用这些化合物的方法，还提供包含具有杀藻活性的化合物的配方和组合物。
• US9131687B2
  申请人：——

  公开号：US9131687B2

  公开（公告）日：2015-09-15
• [EN] ROSEOBACTICIDES AND USES THEREOF<br/>[FR] ROSÉOBACTICIDES ET LEURS UTILISATIONS
  申请人：HARVARD COLLEGE

  公开号：WO2012033631A2

  公开（公告）日：2012-03-15

  Embodiments of the invention relate to compounds and methods for controlling algal growth, for example, in bodies of water or surfaces exposed to algae. Provided are compounds having algicidal activities and methods of use of these compounds as well as formulations and compositions comprising the compound having algicidal activities.