alpha-GalCer;KRN7000

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: alpha-GalCer;KRN7000
• 英文别名: N-[3,4-dihydroxy-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]hexacosanamide
• 化学式: C₅₀H₉₉NO₉
• 分子量: 858.3
• InChiKey: VQFKFAKEUMHBLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16
• 重原子数：
  60
• 可旋转键数：
  44
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.98
• 拓扑面积：
  169
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• MODIFIED-GALACTOSYL CERAMIDE FOR THE TREATMENT OF CANCEROUS DISEASES
  申请人：The Scripps Research Institute

  公开号：EP2056842B1

  公开（公告）日：2012-10-17
• METHODS AND COMPOSITIONS FOR TREATMENT OF METABOLIC DISORDERS
  申请人：Beth Israel Deaconess Medical Center, Inc.

  公开号：US20140079771A1

  公开（公告）日：2014-03-20

  The present invention relates to the discovery that increases in invariant NKT cell (iNKT) number and/or activity can reduce the incidence or severity of metabolic disorders such as obesity and diabetes. The invention accordingly features methods, kits, and compositions for the treatment of such metabolic disorders by administration of a composition capable of increasing iNKT activity.
• US9907848B2
  申请人：——

  公开号：US9907848B2

  公开（公告）日：2018-03-06