Achyrofuran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: Achyrofuran
• 英文别名: 2-methyl-1-[1,3,7,9-tetrahydroxy-4-(2-hydroxy-3-methylbut-3-enyl)-6-(2-methylbutanoyl)-8-(3-methylbut-2-enyl)dibenzofuran-2-yl]butan-1-one
• 化学式: C₃₂H₄₀O₈
• 分子量: 552.7
• InChiKey: WXPMFVVMYYHSEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  148
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF
  申请人：Kantrowitz Evan R.

  公开号：US20120028892A1

  公开（公告）日：2012-02-02

  The invention is directed to a compound according to formula (I). The compounds of formula (I) include prodrugs, pharmaceutically acceptable salts, stereoisomer mixtures, and enantiomers thereof. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier and to methods for treating diabetes by administering such a pharmaceutical composition alone or in combination with other therapeutic agents. The invention is also directed to inhibitors of fructose-1,6-bisphosphatase.

  该发明涉及一种符合式（I）的化合物。符合式（I）的化合物包括前药、药物可接受的盐、立体异构体混合物及其对映体。该发明还涉及一种药物组合物，包括符合式（I）的化合物和药物可接受的载体，以及通过单独或与其他治疗剂联合给药该药物组合物治疗糖尿病的方法。该发明还涉及果糖-1,6-二磷酸酶的抑制剂。
• Utilization of achyrocline satureoides ("Marcela") extracts and liposomal preparations of natural and semi-synthetic flavonoids for the prevention and treatment of the consequences of stroke and neurodegenerative diseases
  申请人：——

  公开号：US20030055103A1

  公开（公告）日：2003-03-20

  Discovery of a neuroprotective effect in vivo of Achyrocline satureoides (“Marcela”) extracts and of liposomal preparations of natural and semi-synthetic flavonoids structurally related to quercetin. This effect is obtained mainly through antiapoptotic mechanisms, complementary and different of the antioxidant actions of flavonoids. The compounds will be beneficial for the prevention and treatment of stroke and neurodegenerative and aging brain lesions. These benefits will be obtained by the administration of compositions comprising one or various compounds of general formula 1. The liposomal preparation of these compounds increases neuroprotection and will be the preferred application. 1

  在体内发现具有神经保护作用的 Achyrocline satureoides (Marcela"）提取物以及与槲皮素结构相关的天然和半合成类黄酮脂质体制剂的体内神经保护作用。这种作用主要是通过抗细胞凋亡机制获得的，与类黄酮的抗氧化作用互补且不同。这些化合物将有利于预防和治疗中风、神经退行性病变和脑老化病变。这些益处可通过服用包含一种或多种通式 1 化合物的组合物来获得。这些化合物的脂质体制剂可增强神经保护作用，将是首选应用。 1
• PROCESS FOR OBTAINING A STANDARDISED EXTRACT OF QUERCETIN AND 3-0-METHYLQUERCETIN FROM FLOWERS OF MACELA (ACHYROCLINE SATUREIOIDES), AND COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID EXTRACT
  申请人：Natura Cosméticos S.A.

  公开号：EP2512495A1

  公开（公告）日：2012-10-24
• PROCESS FOR OBTAINING A STANDARDISED EXTRACT OF QUERCETIN AN 3-O-METHYLQUERCETIN FROM FLOWERS OF MACELA (ACHYROCLINE SATUREIOIDES), AND COSMETIC AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID EXTRACT
  申请人：Natura Cosméticos S.A.

  公开号：EP2512495B1

  公开（公告）日：2015-09-09
• PROCESS TO OBTAIN A STANDARDIZED EXTRACT OF QUERCETIN AND 3-O-METHYLQUERCETIN FROM INFLORESCENCES OF MACELA-DO-CAMPO, A COSMETIC, PHARMACEUTICAL AND VETERINARY COMPOSITION CONTAINING EXTRACT OF MACELA-DO-CAMPO, THE USE OF THIS EXTRACT AND THE METHOD OF APPLICATION OF THE AFORESAID EXTRACT
  申请人：de Moura Sa Rocha Vanessa

  公开号：US20130012577A1

  公开（公告）日：2013-01-10

  It describes an extraction process for obtaining a standardized extract of quercetin and 3-0-methylquercetin from inflorescences of macela-do-campo ( Achyrocline satureioides ) characterized by comprising of the following steps: A) grinding the inflorescences of Achyrocline satureioides to obtain a material of ground plant; B) submitting the ground plant to at least four sequential stages of hydro-alcoholic extraction at a temperature from 60° C. to 80° C.1 for 3 to 4 hours for each stage, in order to obtain 4 intermediary hydro-alcoholic extracts; C) combining the 4 intermediary hydro-alcoholic extracts; D) concentrating the intermediary hydro-alcoholic extracts mixture; in order to obtain up to a maximum of 20% of the initial mass of the intermediary hydro-alcoholic extracts; E) drying the material obtained in (D). It also describes cosmetic, pharmaceutical and veterinary compositions containing the aforesaid extract of macela-do-campo, destined for the prevention and treatment of the damages arising from inflammatory, microbial and oxidation/lypoperoxidation reactions. The use and method of application of the aforesaid extract of macela are also described.

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