austrasulfone | 76928-46-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: austrasulfone
• 英文别名: 4-ethenylsulfonylbutan-2-one
• CAS: 76928-46-6
• 化学式: C₆H₁₀O₃S
• 分子量: 162.21
• InChiKey: YKCAPWJWQQTXTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  dihydroaustrasulfone alcohol 在 4-二甲氨基吡啶 、 三乙胺 、 对甲苯磺酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以90%的产率得到austrasulfone
  参考文献：
  名称：

  A neuroprotective sulfone of marine origin and the in vivo anti-inflammatory activity of an analogue

  摘要：

  Our continuing effort of searching bioactive substances from the Formosan soft coral Cladiella australis has led to the isolation of a bioactive substance austrasulfone (1), which possesses significant neuroprotective activities. A straightforward synthesis of 1 was achieved by a two-step reaction sequence. Dihydroaustrasulfone alcohol (3), the synthetic precursor of 1, not only exhibited in vitro anti-inflammatory activity, but also showed potent therapeutic ability in the treatment of neuropathic pain, atherosclerosis, and multiple sclerosis in rats. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.09.067

文献信息

• A neuroprotective sulfone of marine origin and the in vivo anti-inflammatory activity of an analogue
  作者：Zhi-Hong Wen、Chih-Hua Chao、Ming-Hsuan Wu、Jyh-Horng Sheu

  DOI：10.1016/j.ejmech.2010.09.067

  日期：2010.12

  Our continuing effort of searching bioactive substances from the Formosan soft coral Cladiella australis has led to the isolation of a bioactive substance austrasulfone (1), which possesses significant neuroprotective activities. A straightforward synthesis of 1 was achieved by a two-step reaction sequence. Dihydroaustrasulfone alcohol (3), the synthetic precursor of 1, not only exhibited in vitro anti-inflammatory activity, but also showed potent therapeutic ability in the treatment of neuropathic pain, atherosclerosis, and multiple sclerosis in rats. (C) 2010 Elsevier Masson SAS. All rights reserved.