2-Hydroxy-N-(1,3,4-trihydroxyoctadecan-2-yl)tetracosanamide | 2433-99-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: 2-Hydroxy-N-(1,3,4-trihydroxyoctadecan-2-yl)tetracosanamide
• CAS: 2433-99-0
• 化学式: C₄₂H₈₅NO₅
• 分子量: 684.1
• InChiKey: ZFUXWVVVWGWGPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.8
• 重原子数：
  48
• 可旋转键数：
  39
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.98
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• COMPOSITION FOR EXTERNAL APPLICATION CONTAINING A CERAMIDE, A DERIVATIVE THEREOF AND AN EXTRACT OF HIBISCI CORTEX
  申请人：AMOREPACIFIC CORPORATION

  公开号：US20200179260A1

  公开（公告）日：2020-06-11

  The present disclosure relates to an external-use skin preparation composition containing a natural ceramide, a ceramide derivative, and a Hibisci cortex extract, and more specifically, the present disclosure relates to an external-use skin preparation composition containing these ingredients, thereby being effective for enhancing skin moisturizing ability, reducing skin wrinkles, and enhancing elasticity. In addition, the present disclosure relates to use of the composition, and a method for improving skin moisturization, reducing skin wrinkles, and/or improving skin elasticity by using the composition.

  本公开涉及一种含有天然酯化酰胺、酰胺衍生物和芙蓉皮提取物的外用皮肤制剂组合物，更具体地说，本公开涉及一种含有这些成分的外用皮肤制剂组合物，因此对于增强皮肤保湿能力、减少皮肤皱纹和增强弹性具有有效作用。此外，本公开还涉及使用该组合物的方法以及通过使用该组合物改善皮肤保湿、减少皮肤皱纹和/或改善皮肤弹性的方法。
• Bi-phase micellar liquid product comprising ceramides
  申请人：L'OREAL

  公开号：US10813852B2

  公开（公告）日：2020-10-27

  The present disclosure relates to bi-phase micellar liquid products that include ceramides and other components that are beneficial to the skin. In particular, the products include: (a) a fatty phase comprising one or more fatty compounds and one or more silicones; and (b) an aqueous phase comprising one or more ceramides, one or more water-soluble solvents, one or more surfactants, and water. The products are particularly unique because the ceramides are solubilized in the aqueous phase of the products. In addition to being useful for cleansing the skin, the products support natural lipid barrier function of the skin and improve skin hydration.

  本公开涉及双相胶束液体产品，其中包括神经酰胺和其他对皮肤有益的成分。具体而言，产品包括(a) 脂肪相，包括一种或多种脂肪化合物和一种或多种有机硅；以及 (b) 水相，包括一种或多种神经酰胺、一种或多种水溶性溶剂、一种或多种表面活性剂和水。由于神经酰胺溶解在产品的水相中，因此产品尤为独特。除了用于清洁皮肤外，这些产品还能支持皮肤的天然脂质屏障功能，提高皮肤的保湿性。
• Composition for external application containing a ceramide, a derivative thereof and an extract of Hibisci cortex
  申请人：AMOREPACIFIC CORPORATION

  公开号：US11166899B2

  公开（公告）日：2021-11-09

  The present disclosure relates to an external-use skin preparation composition containing a natural ceramide, a ceramide derivative, and a Hibisci cortex extract, and more specifically, the present disclosure relates to an external-use skin preparation composition containing these ingredients, thereby being effective for enhancing skin moisturizing ability, reducing skin wrinkles, and enhancing elasticity. In addition, the present disclosure relates to use of the composition, and a method for improving skin moisturization, reducing skin wrinkles, and/or improving skin elasticity by using the composition.

  本公开涉及一种含有天然神经酰胺、神经酰胺衍生物和 Hibisci 皮质提取物的外用皮肤制剂组合物，更具体地说，本公开涉及一种含有这些成分的外用皮肤制剂组合物，从而可有效增强皮肤保湿能力、减少皮肤皱纹和增强弹性。 此外，本公开还涉及该组合物的用途，以及通过使用该组合物提高皮肤保湿能力、减少皮肤皱纹和/或提高皮肤弹性的方法。
• Pharmaceutical or cosmetic composition and use of a PKC inhibitor with an MMP inhibitor for inhibiting langerhans cell migration
  申请人：Msika Philippe

  公开号：US20080221017A1

  公开（公告）日：2008-09-11

  The invention concerns a pharmaceutical or cosmetic composition, characterized in that it comprises at least a compound for inhibiting Langerhans' cell migration, said active compound being selected in the group consisting of protein kinase C (PKC) inhibiting compounds, matrix metalloprotease (MMP) inhibiting compounds, and combinations thereof, and at least a pharmaceutically or cosmetically acceptable carrier. Said composition enables to inhibit considerably Langerhans' cell migration induced by the presence of an allergenic agent.
• HAIR COSMETIC COMPOSITION
  申请人：Sazanami Fumiko

  公开号：US20080299063A1

  公开（公告）日：2008-12-04

  Provided is a hair cosmetic composition containing (A) an amidoamine (1) or an etheramine (2), or a salt thereof, (B) a branched fatty acid (3) or a salt thereof, (C) a silicone, and water: in the formula (1), R 1 represents an aliphatic C 11-23 hydrocarbon group, R 2 represents H or a C 1-4 alkyl group, and m stands for a number from 2 to 4; in the formula (2), R 3 represents a C 6-24 alkyl or alkenyl group, and R 4 and R 5 each represents a C 1-6 alkyl group or a group -(AO) n H, in which A represents a C 2-4 alkylene group and n stands for a number from 1 to 6; and in the formula (3), R 6 represents a methyl or ethyl group, and p stands for a number from 3 to 36.