methyl N-[3-(4-methyl-1-piperazinyl)-propyl]dithiocarbamate | 76029-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: methyl N-[3-(4-methyl-1-piperazinyl)-propyl]dithiocarbamate
• 英文别名: Methyl [3-(4-methylpiperazin-1-yl)propyl]carbamodithioate；methyl N-[3-(4-methylpiperazin-1-yl)propyl]carbamodithioate
• CAS: 76029-30-6
• 化学式: C₁₀H₂₁N₃S₂
• 分子量: 247.429
• InChiKey: BWLSMSRGVHCNJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  75.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Cephem and cepham compounds, processes for their preparation, pharmaceutical compositions containing them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0013762A2

  公开（公告）日：1980-08-06

  Cephem and Cepham compounds of the formula: wherein R1 is amino or a protected amino, R2 is hydrogen or certain substituent. R3 is hydrogen or lower alkyl, R4 is hydrogen or certain substituent, Rs is carboxy or a protected carboxy and the heavy solid line means single or double-bond and pharmaceutically acceptable salt thereof and processes for their preparation, and also an antibacterial composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient. The invention also relates to the starting compounds and their preparation.

  式中的 Cephem 和 Cepham 化合物： 式中 R1 是氨基或受保护的氨基、 R2 是氢或某些取代基 R3 是氢或低级烷基、 R4 是氢或某些取代基、 Rs 是羧基或受保护的羧基 重实线表示单键或双键及其药学上可接受的盐和它们的制备工艺，以及一种抗菌组合物，其有效成分包括上述化合物与药学上可接受的、基本上无毒的载体或赋形剂。本发明还涉及起始化合物 及其制备。
• Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0029998A2

  公开（公告）日：1981-06-10

  A new cephem compound of the formula: wherein R' is amino or a substituted amino group; R2 is carboxy or a protected carboxy group; R is a group of the formula: -A1-R3a [in which A, is hydroxy(lower)alkylene, amino-(lower)alkylene, protected amino-(lower)alkylene, lower alkenylene or hydroxyimino(lower)alkylene wherein the hyrogen atom of the hydroxyimino group may be replaced with a lower aliphatic hydrocarbon group; and R3a is carboxy or a protected carboxy group] or a group of the formula:

  一种新的 Cephem 化合物，其化学式为 其中 R' 是氨基或取代的氨基； R2 是羧基或受保护的羧基； R 是式中的基团：-A1-R3a [其中 A 是羟基（低级）亚烷基、氨基（低级）亚烷基、受保护氨基（低级）亚烷基、低级烯基或羟基亚氨基（低级）亚烷基，其中羟基亚氨基基团的偶氮原子可被低级脂肪族烃基团取代；和 R3a 是羧基或受保护的羧基] 或 式中的一个基团：
• Starting compounds for preparing cephem compounds and processes for their preparation
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0064582A1

  公开（公告）日：1982-11-17

  Starting compounds for preparing cephem compounds of formula wherein R' is amino or a protected amino and X' is carbonyl or a group of the formula: in which R2 is hydrogen, acyl, aryl which may be substituted with suitable substituent(s), lower alkyl substituted with suitable substituent(s), lower alkenyl, lower alkynyl, cycloalkyl which may be substituted with suitable substituent(s), cyclo(lower) alkenyl, or S or 0 containing 5-membered heterocyclic group substituted with oxo group(s), and ester and salts thereof, can be prepared by different processes and the cephem compounds, which possess valuable pharmacological properties, can be prepared from such starting compounds.

  用于制备式中 R'为氨基或受保护氨基，X'为羰基或式中基团的头孢化合物的起始化合物，其中 R2 为氢、酰基、可被适当取代基取代的芳基、可被适当取代基取代的低级烷基、低级烯基、低级炔基、可被适当取代基取代的环烷基、环（低）烯基、或被氧代基取代的 S 或含 0 的 5 元杂环基团，以及它们的酯和盐，可以通过不同的工艺制备，具有重要药理特性的头孢化合物可以由这些起始化合物制备。
• 5-Thio-tetrazol compounds and their preparation
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0095029A1

  公开（公告）日：1983-11-30

  Starting compounds of the formula wherein R is a group of the formula: --R3a [in which is hydroxy (C1-C6) alkylene, amino (C1-C6) alkylene, protected amino (C1-C6) alkylene, (C2-C6)alkenylene, (C,-C6) alkylene having an oxo group; or hydroxyimino (C1-C6) alkylene wherein the hydrogen atom of the hydroxyimino group may be replaced with a (C1-C6) aliphatic hydrocarbon group; and R38 is carboxy or an esterified carboxy group] or a group of the formula: [in which A2 is (C1-C6) alkylene which may have an oxo group; and R3b is carboxy, esterified carboxy, an aliphatic or aromatic group] and R10 is hydrogen or a mercapto-protective group, and a salt thereof and processes for their preparation. The compounds are useful for the preparation of cephem compounds.

  式中的起始化合物 其中 R 是式中的基团：--R3a [其中为羟基（C1-C6）亚烷基、氨基（C1-C6）亚烷基、受保护氨基（C1-C6）亚烷基、(C2-C6)烯基、具有氧代基团的（C,-C6）亚烷基； 或羟基亚氨基 (C1-C6) 亚烷基，其中羟基亚氨基基团的氢原子可被 (C1-C6) 脂肪族烃基团取代；以及 R38 是羧基或酯化羧基]或 式中的基团： [其中 A2 是（C1-C6）亚烷基，可带有一个氧代基团；以及 R3b 是羧基、酯化羧基、脂肪族或芳香族基团]和 R10 是氢或巯基保护基团，以及它们的盐 及其制备工艺。这些化合物可用于制备 cephem 化合物。
• US4331665A
  申请人：——

  公开号：US4331665A

  公开（公告）日：1982-05-25