(E)-4,5,9-trithiadeca-1,6-diene 9-oxide | 104228-48-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 英文名称: (E)-4,5,9-trithiadeca-1,6-diene 9-oxide
• 英文别名: (E)-2-oxo-2,6,7-trithiadeca-4,9-diene；garlicnin L-2；garlicnin B₃；(E,Z)-4,5,9-trithiadeca-1,6-diene 9-oxide；(Z)-[3-(Methylsulfinyl)-1-propenyl] 2-propenyl disulfide；(E)-3-methylsulfinyl-1-(prop-2-enyldisulfanyl)prop-1-ene
• CAS: 104228-48-0
• 化学式: C₇H₁₂OS₃
• 分子量: 208.37
• InChiKey: FPQGSXSLZNUUFB-GQCTYLIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  86.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  allyl methyl-thiosulfinate 以 水 、 丙酮 为溶剂， 反应 36.0h， 以0.045 g的产率得到(E)-4,5,9-trithiadeca-1,6-diene 9-oxide
  参考文献：
  名称：

  烷基硫代亚磺酸酯的化学性质。9. 大蒜中的抗血栓有机硫化合物：结构、机理和合成研究

  摘要：

  合成 de l'ajoene (oxyde-9 de trithia-4,5,9 dodecatriene-1,6,11) et de quelques 类似物

  DOI：

  10.1021/ja00282a033

文献信息

• Organosulfur Compounds, a Method of Making Organosulfur Compounds and their Use for Inhibiting the Growth of Tumour Cells
  申请人：Kaschula Catherine Hart

  公开号：US20110190368A1

  公开（公告）日：2011-08-04

  Organosulfur compounds of the general formula (2) are described, wherein R 1 and R 2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R 1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR 3 , NR 4 R 5 , COOR 6 , CON—R 7 R 8 , in which R 3 is selected from H, COR 9 , para-methoxybenzyl and trialkylsilyl, in which R 9 is alkyl or substituted alkyl; R 4 N and R 5 are alkyl or R 4 and R 5 together form a phthalimido group; R 6 is alkyl or substituted alkyl; and R 7 and R 8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R 1 and R 2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumour cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.

  本文描述了通式（2）的有机硫化合物，其中R1和R2是线性或支链的C1-C5烷基；线性或支链的C1-C5烯基，其中R1不是丙烯基；取代的线性或支链的C1-C5烯基或取代的线性或支链的C1-C5烷基，其中取代基从OR3，NR4R5，COOR6，CON—R7R8中选择，其中R3从H，COR9，对甲氧基苄基和三烷基硅烷中选择，其中R9是烷基或取代烷基；R4N和R5是烷基或R4和R5组成邻二甲酰亚胺基团；R6是烷基或取代烷基；R7和R8是烷基或取代烷基；取代或未取代的芳香族，特别是当R1和R2为苄基，对甲氧基苄基和/或邻，对-甲氧基苄基和取代或未取代的杂环芳香族时。这些化合物可用于抑制肿瘤细胞生长和治疗癌症。还描述了一种制备这些化合物的制药组合物和方法。
• Antimicrobial blood treatment using allicin and related compounds
  申请人：——

  公开号：US20030077264A1

  公开（公告）日：2003-04-24

  Methods and compositions prolonging the storage life and/or increasing the safety of a blood product, such as whole blood, red blood cells, white blood cells, platelets, serum and aqueous additive solutions for storage of such blood products are provided. Storage solutions of this invention comprise a composition selected from the group consisting of garlic extract, allicin, other microorganism-growth-inhibiting compounds derived from garlic, and analogs and derivatives of allicin and said other compounds, in an amount effective to inhibit growth of at least one selected microorganism which is a bacterium, virus, fungus or parasite. The storage additive solutions of this invention can increase platelet storage life by at least about 20%, preferably at least about 40%.

  本发明提供了一种延长血液制品（如全血、红细胞、白细胞、血小板、血清和用于储存这种血液制品的水性添加剂溶液）的储存寿命和/或提高安全性的方法和组合物。本发明的储存溶液包括从大蒜提取的化合物、大蒜素、从大蒜中提取的其他微生物生长抑制化合物以及大蒜素和该等化合物的类似物和衍生物中选择的一种组成，其有效抑制至少一种选择的细菌、病毒、真菌或寄生虫的生长。本发明的储存添加剂溶液可以将血小板的储存寿命延长至少20％，最好至少40％。
• Novel organic trithio oxides and method for the preparation thereof
  申请人：THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

  公开号：EP0185324A2

  公开（公告）日：1986-06-25

  This invention relates to novel organic trithio oxides of the formula: R1-X-R-X1-R1 wherein R is selected from X is selected from X' is selected from -S-S-, and each R' is independently selected from carboxyalkyl, alkoxy, alkylthio, amino, alkylamino and acyl substituted and unsubstituted lower alkyl, lower alkenyl, lower alkynyl, phenyl and lower alkylphenyl; provided when R is then R1 is not in both instances -CH2CH=CH2. This invention also relates to a method of preparing the above-identified compounds by heating and further oxidiz- ing various oxides of organic disulfides and to antithrombotic uses of the compounds.

  本发明涉及式如下的新型有机三硫氧化物：R1-X-R-X1-R1 其中 R 选自 X选自 X'选自-S-S-、 且每个 R'独立地选自羧基烷基、烷氧基、烷硫基、氨基、烷基氨基和酰基取代和未取代的低级烷基、低级烯基、低级炔基、苯基和低级烷基苯基；条件是当 R 为 则 R1 在两种情况下均不是-CH2CH=CH2。 本发明还涉及一种通过加热和进一步氧化各种有机二硫化物来制备上述化合物的方法，以及这些化合物的抗血栓用途。
• US4643994A
  申请人：——

  公开号：US4643994A

  公开（公告）日：1987-02-17
• US8524781B2
  申请人：——

  公开号：US8524781B2

  公开（公告）日：2013-09-03