1-(3-Methylphenyl)piperazin-2-one | 893748-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(3-Methylphenyl)piperazin-2-one
• CAS: 893748-27-1
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.24
• InChiKey: MUYAYGHCSVPTIE-UHFFFAOYSA-N

物化性质

• 沸点：
  424.2±45.0 °C(Predicted)
• 密度：
  1.115±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• ANTHRANILAMIDE INHIBITORS OF AURORA KINASE
  申请人：Johnson Neil W.

  公开号：US20080182852A1

  公开（公告）日：2008-07-31

  The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; where R 1 , R 2 , R 3 , R 4 , r and s are as previously defined. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.

  本发明涉及以下公式所代表的化合物： 或其药学上可接受的盐； 其中R1、R2、R3、R4、r和s如前所定义。本发明的化合物在治疗与Aurora激酶活性相关的疾病，如癌症方面是有用的。
• NEW CHEMICAL COMPOUNDS (DERIVATIVES) AND THEIR APPLICATION FOR THE TREATMENT OF ONCOLOGICAL DISEASES
  申请人：LIMITED LIABILITY COMPANY "NATIONAL PHARMACEUTICAL TECHNOLOGIES"

  公开号：US20160200729A1

  公开（公告）日：2016-07-14

  The invention relates to novel chemical compounds of general formula I, in which L A , L B , L C , ring A, ring B, R A , R B , R C , R D , R E and R F have are defined in the description, and which are protein kinases inhibitors. The invention also relates to pharmaceutical compositions containing said compounds and also to the use of said compounds for treatment and/or prevention of diseases related with aberrant protein kinase activity.
• US7625903B2
  申请人：——

  公开号：US7625903B2

  公开（公告）日：2009-12-01
• US7884098B2
  申请人：——

  公开号：US7884098B2

  公开（公告）日：2011-02-08
• US9695182B2
  申请人：——

  公开号：US9695182B2

  公开（公告）日：2017-07-04