Dihexadecyldithiophosphat | 37601-68-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机二硫代磷酸及其衍生物
• 英文名称: Dihexadecyldithiophosphat
• 英文别名: O,O-Dihexadecyl-dithiophosphat；O,O'-Bis-hexadecyl-dithiophosphorsaeure；dithiophosphoric acid O,O'-dihexadecyl ester；Dihexadecoxy-sulfanyl-sulfanylidene-lambda5-phosphane；dihexadecoxy-sulfanyl-sulfanylidene-λ5-phosphane
• CAS: 37601-68-6
• 化学式: C₃₂H₆₇O₂PS₂
• 分子量: 578.989
• InChiKey: JWOPLIXEIJVTGP-UHFFFAOYSA-N

物化性质

• 沸点：
  617.9±24.0 °C(Predicted)
• 密度：
  0.940±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  17.2
• 重原子数：
  37
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-十六烷醇 在 tetraphosphorus decasulfide 作用下， 以89%的产率得到Dihexadecyldithiophosphat
  参考文献：
  名称：

  金上的新型二十六烷基二硫代磷酸盐 SAM 提供了对吸附质螯合对二烷基二硫代次膦酸 SAM 中底物形态的异常依赖性的洞察

  摘要：

  我们报告了由二十六烷基二硫代磷酸 (C16)2DDP 形成的新自组装单层 (SAM) 的形成和表征，并将它们的性质与由结构相似的吸附质二十六烷基二硫代次膦酸 (C16)2DTPA 形成的 SAM 的性质进行了比较。使用 X 射线光电子能谱、反射吸收红外光谱、接触角测量和电化学阻抗谱对新的 (C16)2DDP SAM 进行了表征。数据表明，(C16)2DDP 在通过电子束蒸发形成的金膜上形成 SAM，其中所有吸附物都与金螯合，而 (C16)2DTPA SAMs 中 40% 的吸附物是单齿的。(C16)2DDP SAM 的烷基链也比 (C16)2DTPA SAM 的烷基链更不密集和有序。要了解这些差异，我们提出的密度泛函理论计算表明，两种吸附质的几何和电子结构之间只有很小的差异，并且金 (I) 离子的单齿和双齿结合之间的能量差异对于两种吸附质来说都非常小。该研究得出的结论是，SAM 内分子间相

  DOI：

  10.1021/ja404798q

文献信息

• Modulators of CCR5 chemokine receptor activity
  申请人：——

  公开号：US20020193407A1

  公开（公告）日：2002-12-19

  Compounds of Formula I: 1 (wherein R 1 , R 2 , R 3 , R 4 , Q, and X are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

  化合物的化学式I： 1 （其中R 1 ，R 2 ，R 3 ，R 4 ，Q和X在此处定义）已被描述。这些化合物是CCR5趋化因子受体活性的调节剂。这些化合物在预防或治疗HIV感染以及治疗艾滋病方面是有用的，可以作为化合物或药学上可接受的盐，或作为药物组成部分，可选地与其他抗病毒药物，免疫调节剂，抗生素或疫苗组合使用。还描述了治疗艾滋病的方法以及预防或治疗HIV感染的方法。
• N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists
  申请人：——

  公开号：US20040002504A1

  公开（公告）日：2004-01-01

  The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises administering to that subject a therapeutically effective amount of a compound of formula I: 1 wherein, generally, Q is 2 R 1 is benzyl, phenyl, thiophene or imidazolyl optionally substituted with C 1-4 alkyl or halogen, such as methyl, fluorine or bromine; R 2 is hydrogen or C 1-4 alkyl such as methyl; R 3 is phenyl; R 4 is hydrogen; R 5 is hydrogen or C 1-6 alkylcarbonyl such as methylcarbonyl; X is —SO 2 — or —C(O)N(R 2 )SO 2 — where R 2 is preferably hydrogen; Y is a bond, CH 2 or Z 1 where Z 1 is —N(R f )— in which R f is C 1-6 alkylcarbonyl such as ethylcarbonyl; and R 6 is phenyl, pyrazolyl, pyridyl, pyrimidinyl or benzimidazolonyl optionally substituted with one or two groups chosen from C 1-6 alkyl and benzyl, such as methyl, ethyl and benzyl; or a pharmaceutically acceptable salt thereof.

  本发明提供了一种治疗患有疾病（如精神分裂症）的受试者的方法，其中该疾病的治疗需要使用NK-3拮抗剂，包括向该受试者施用化合物I的治疗有效量： 1 其中，通常情况下， Q是 2 R 1 是苄基、苯基、噻吩或咪唑基，可选择地用C 1-4 烷基或卤素（如甲基、氟或溴）取代； R 2 是氢或C 1-4 烷基，如甲基； R 3 是苯基； R 4 是氢； R 5 是氢或C 1-6 烷基羰基，如甲基羰基； X是—SO 2 —或—C(O)N(R 2 )SO 2 —，其中R 2 最好是氢； Y是键、CH 2 或Z 1 ，其中Z 1 是—N(R f )—，其中R f 是C 1-6 烷基羰基，如乙基羰基；以及 R 6 是苯基、吡唑基、吡啶基、嘧啶基或苯并咪唑基，可选择地用来自C 1-6 烷基和苄基的一个或两个基团取代，如甲基、乙基和苄基； 或其药学上可接受的盐。
• N-(3-(4-Substituted-1-piperiding1)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists
  申请人：Chambers Stuart Mark

  公开号：US20070117847A1

  公开（公告）日：2007-05-24

  The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises administering to that subject a therapeutically effective amount of a compound of formula I: wherein, generally, Q is R 1 is benzyl, phenyl, thiophene or imidazolyl optionally substituted with C 1-4 alkyl or halogen, such as methyl, fluorine or bromine; R 2 is hydrogen or C 1-4 alkyl such as methyl; R 3 is phenyl; R 4 is hydrogen; R 5 is hydrogen or C 1-6 alkylcarbonyl such as methylcarbonyl; X is —SO 2 — or —C(O)N(R 2 )SO 2 — where R 2 is preferably hydrogen; Y is a bond, CH 2 or Z 1 where Z 1 is —N(R f )— in which R f is C 1-6 alkylcarbonyl such as ethylcarbonyl; and R 6 is phenyl, pyrazolyl, pyridyl, pyrimidinyl or benzimidazolonyl optionally substituted with one or two groups chosen from C 1-6 alkyl and benzyl, such as methyl, ethyl and benzyl; or a pharmaceutically acceptable salt thereof.

  本发明提供了一种治疗患有疾病（如精神分裂症）的受试者的方法，该疾病需要给予NK-3拮抗剂治疗，其中包括向该受试者给予化合物I的治疗有效量，化合物I的一般结构如下：其中，Q是；R1是苄基、苯基、噻吩基或咪唑基，可选地取代C1-4烷基或卤素，例如甲基、氟或溴；R2是氢或C1-4烷基，例如甲基；R3是苯基；R4是氢；R5是氢或C1-6烷基羰基，例如甲基羰基；X是-SO2-或-C（O）N（R2）SO2-，其中R2最好是氢；Y是键，CH2或Z1，其中Z1是-N（Rf）-，其中Rf是C1-6烷基羰基，例如乙酰基；R6是苯基、吡唑基、吡啶基、嘧啶基或苯并咪唑基，可选地取代一或两个来自C1-6烷基和苄基的基团，例如甲基、乙基和苄基；或其药学上可接受的盐。
• Lubricant compositions
  申请人：ETHYL PETROLEUM ADDITIVES, INC.

  公开号：EP0459656A1

  公开（公告）日：1991-12-04

  Gear oils and gear oil additive concentrates of enhanced positraction performance are described. They comprise: (i) at least one oil-soluble sulfur-containing extreme pressure or antiwear agent; (ii) at least one oil-soluble amine salt of a partial ester of an acid of phosphorus; and (iii) at least one oil-soluble succinimide of the formula where R₁ is an alkyl or alkenyl group having an average of 8 to 50 carbon atoms, and each of R₂, R₃ and R₄ is a hydrogen atom or an alkyl or alkenyl group having an average of up to about 4 carbon atoms. These compositions preferably contain one, more preferably two, and most preferably all three of the following additional components: (iv) at least one amine salt of a carboxylic acid; (v) at least one nitrogen-containing ashless dispersant; and (vi) at least one trihydrocarbyl ester of a pentavalent acid of phosphorus.

  所述齿轮油和齿轮油添加剂浓缩物具有增强的正曳引性能。它们包括：(i) 至少一种油溶性含硫极压剂或抗磨剂；(ii) 至少一种磷酸部分酯的油溶性胺盐；(iii) 至少一种油溶性琥珀酰亚胺，其式为 其中 R₁ 是平均具有 8 至 50 个碳原子的烷基或烯基，R₂、R₃ 和 R₄ 各为氢原子或平均具有最多约 4 个碳原子的烷基或烯基。这些组合物最好含有一种，更优选两种，最优选全部三种下列附加成分：(iv) 至少一种羧酸胺盐； (v) 至少一种含氮无灰分散剂；以及 (vi) 至少一种五价磷酸三烃基酯。
• Process for producing copper nanoparticles
  申请人：Liu Weimin

  公开号：US20060053972A1

  公开（公告）日：2006-03-16

  The present invention provides a process for producing copper nanoparticles, comprising steps of: a) reacting an aqueous solution containing a reductant with an aqueous solution of a copper salt while stirring for 1-8 min, wherein the reductant being one or more selected from a group consisting of hydrazine hydrate, sodium borohydride and sodium hypophosphite; b) adding an apolar organic solution containing the extracting agent and continuing the stirring for 0.5-1.5 hrs, said extracting agent being one or more selected from the group consisting of alkyl dithiocarbonic acid and salts thereof, O,O′-dialkyl dithiophosphoric acid and salts thereof, and dialkylamino dithioformic acid and salts and said apolar organic solution being one selected from the group consisting of benzene, toluene and straight or branched alkanes having 6-12 carbon atoms, wherein the alkyl having 6-20 carbon atoms; and c) post-treating the reaction product to obtain copper nanoparticles.

  本发明提供了一种生产纳米铜颗粒的工艺，包括以下步骤：a) 将含有还原剂的水溶液与铜盐水溶液反应，同时搅拌 1-8 分钟，其中还原剂为选自水合肼、硼氢化钠和次磷酸钠组成的组中的一种或多种；b) 加入含有萃取剂的极性有机溶液，继续搅拌 0.5-1.5小时，所述萃取剂为选自烷基二硫代碳酸及其盐、O,O′-二烷基二硫代磷酸及其盐和二烷基氨基二硫代甲酸及其盐组成的组中的一种或多种，所述极性有机溶液为选自苯、甲苯和具有6-12个碳原子的直链或支链烷烃组成的组中的一种，其中烷基具有6-20个碳原子；c) 对反应产物进行后处理，以获得纳米铜颗粒。