cis-amminedichloro(cyclobutylamine)platinum(II) | 94157-39-8

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: cis-amminedichloro(cyclobutylamine)platinum(II)
• 英文别名: cis-Pt(cba)(NH3)Cl2；cis-Pt(cyclobutylamine)(NH3)Cl2；cis-Pt(NH3)(cba)Cl2；cis-Pt(NH3)(cyclobutylamine)Cl2；Azane;cyclobutanamine;platinum(2+);dichloride
• CAS: 94157-39-8
• 化学式: C₄H₁₂Cl₂N₂Pt
• 分子量: 354.139
• InChiKey: BNXXFSDLAURBPL-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.33
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cis-amminedichloro(cyclobutylamine)platinum(II) 、 鸟苷 以 重水 为溶剂， 生成 cis-Pt(cyclobutylamine)(NH3)(guanosine)2(2+) 、 cis-Pt(cyclobutylamine)2(guanosine)2(2+)
  参考文献：
  名称：

  Multinuclear magnetic resonance studies of the reactions of the antitumor complexes cis-Pt(L)2X2 and cis-Pt(NH3)(L)X2 (L=cyclobutylamine and cyclopentylamine) with guanosine and other bases and crystal structures of Pt(cyclopentylamine)2I2

  摘要：

  The crystal structures of two Pt(cyclopentylamine) I-2(2) compounds were determined by X-ray diffraction methods. Both crystals contain disordered cyclopentylamine ligands. Crystal I contains two independent trans-Pt(cyclopentylamine)(2)I-2 molecules and all the C atoms are disordered on two positions. The second crystal (II) is most interesting since it contains both cis- and trans-Pt(cyclopentylamine)(2)I-2 isomers in the same unit cell. It was prepared from the recrystallization of the cis isomer in acetone. The C atoms of the trans molecule in crystal II are disordered on two positions, while only one position was determined in the cis molecule, although some of the C thermal factors are quite high. The reactions of cis-Pt(amine)(2)X-2 and cis-Pt(NH3)(amine) X-2 (amine = cyclobutylamine and cyclopentylamine) with guanosine in water were studied in different Pt: guanosine proportions by multinuclear (H-1, Pt-195 and N-15) magnetic resonance spectroscopy. The presence of several species in solution was observed. For the mixed-cyclobutylamine compound, N-15 NMR has shown that some of the NH3 ligands have been displaced from the coordination sphere in the presence of an excess of guanosine. The reactions of the two mixed-ligand complexes cis-Pt(NH3)(amine) Cl-2 with 9-methylguanine, inosine and 9-methylhypoxanthine were also studied in water and the results are discussed. (C) 2008 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2008.10.026