1,2-bis(2-hydroxybenzoyl)-1-propanone | 1345020-36-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - α-甲基脱氧安息香黄酮
• 英文名称: 1,2-bis(2-hydroxybenzoyl)-1-propanone
• CAS: 1345020-36-1
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: LOVGMNYWSVIBPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.08
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  57.53
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1,2-bis(2-hydroxybenzoyl)-1-propanone 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以98%的产率得到2-(3-methylbenzofuran-2-yl)phenol
  参考文献：
  名称：

  Catalytic Hydroacylation as an Approach to Homoaldol Products

  摘要：

  A method has been developed for the intermolecular hydroacylation of homoallyl alcohols with salicylaldehydes to furnish homoaldol products In 50-98% yields. The method also applies to the hydroacylation of 2-hydroxystyrenes. This work highlights the use of hydroacylation as a unified approach to both aldol and homoaldol products.

  DOI：

  10.1021/ol202663p
• 作为产物：
  描述：

  水杨醛 、 乙酰苯 在 chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 二苯基甲氧基膦 、 sodium acetate 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以88%的产率得到1,2-bis(2-hydroxybenzoyl)-1-propanone
  参考文献：
  名称：

  Catalytic Hydroacylation as an Approach to Homoaldol Products

  摘要：

  A method has been developed for the intermolecular hydroacylation of homoallyl alcohols with salicylaldehydes to furnish homoaldol products In 50-98% yields. The method also applies to the hydroacylation of 2-hydroxystyrenes. This work highlights the use of hydroacylation as a unified approach to both aldol and homoaldol products.

  DOI：

  10.1021/ol202663p

文献信息

• Catalytic Hydroacylation as an Approach to Homoaldol Products
  作者：Stephen K. Murphy、David A. Petrone、Matthew M. Coulter、Vy M. Dong

  DOI：10.1021/ol202663p

  日期：2011.12.2

  A method has been developed for the intermolecular hydroacylation of homoallyl alcohols with salicylaldehydes to furnish homoaldol products In 50-98% yields. The method also applies to the hydroacylation of 2-hydroxystyrenes. This work highlights the use of hydroacylation as a unified approach to both aldol and homoaldol products.