hexyl magnesium (1+); bromide

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: hexyl magnesium (1+); bromide
• 英文别名: Hexylmagnesium(1+); Bromid
• 化学式: Br*C₆H₁₃Mg
• 分子量: 189.378
• InChiKey: SFXUWNMDTWQSHE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.0
• 重原子数：
  8.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  乙醚 、 hexyl magnesium (1+); bromide 生成 十二烷
  参考文献：
  名称：

  The Electrolysis of Some Higher Aliphatic Organomagnesium Halides in Ethyl Ether

  摘要：

  DOI：

  10.1021/ja01860a022
• 作为产物：
  描述：

  溴己烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 碘 作用下， 生成 hexyl magnesium (1+); bromide
  参考文献：
  名称：

  Gilman; Zoellner; Dickey, Journal of the American Chemical Society, 1929, vol. 51, p. 1580,1585

  摘要：

  DOI：

文献信息

• Cu-Catalyzed Conjugate Addition of Grignard Reagents to Thiochromones: An Enantioselective Pathway for Accessing 2-Alkylthiochromanones
  作者：Qingxiong Yang、Jun Wang、Shihui Luo、Ling Meng

  DOI：10.1055/s-0037-1610225

  日期：2018.9

  The enantioselective incorporation of alkyl groups in thiochromones was realized for the first time by a Cu/(R,S)-PPF-P t Bu2-catalyzed conjugate addition of Grignard reagents to thiochromones. With this method, a series of 2-methylthiochromanones were obtained in good yields (up to 96% yield) with moderate-to-good ee values (up to 87% ee). The established method expedites the synthesis of a large

  通过Cu/(R,S)-PPF-P t Bu2 催化的格氏试剂与硫色酮的共轭加成，首次实现了烷基在硫色酮中的对映选择性掺入。使用这种方法，以良好的收率（最高 96% 的收率）获得了一系列 2-甲基硫代色满酮，其 ee 值中等至良好（最高 87% ee）。已建立的方法加速了大型手性硫代色满酮库的合成，以用于进一步的合成应用和生物学研究。
• (<i>Z</i>)<i>-</i>Trifluoromethyl-Trisubstituted Alkenes or Isoxazolines: Divergent Pathways from the Same Allene
  作者：Chaolun Liu、Glenn P. A. Yap、Casey A. Rowland、Marcus A. Tius

  DOI：10.1021/acs.orglett.0c02546

  日期：2020.9.18

  protonation of trifluoromethyl allenes leads to tri- or tetrasubstituted alkenes with high (Z)-selectivity. Treatment of the same allenes with catalytic Au(I) initiates a reaction cascade that produces isoxazolines in high yield.

  由于涉及氟上非键合电子对的电荷-偶极相互作用，三氟甲基烯丙基的质子化导致具有高（Z）选择性的三或四取代的烯烃。用催化的Au（I）处理相同的烯基会引发反应级联反应，该反应级联可高产率生产异恶唑啉。
• [EN] CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS DE LA CÉRAMIDE GALACTOSYLTRANSFÉRASE POUR LE TRAITEMENT DE MALADIES
  申请人：BIOMARIN PHARM INC

  公开号：WO2017214505A1

  公开（公告）日：2017-12-14

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

  本文描述了化合物、制备这种化合物的方法、含有这种化合物的药物组合物和药物、以及使用这种化合物治疗或预防与酶神经鞘糖脂转移酶（CGT）相关的疾病或紊乱的方法，例如溶酶体贮积症。溶酶体贮积症的例子包括 Krabbe 病和白质变性白血病。
• Preparation of 5-Brominated and 5,5‘-Dibrominated 2,2‘-Bipyridines and 2,2‘-Bipyrimidines
  作者：Peter F. H. Schwab、Frank Fleischer、Josef Michl

  DOI：10.1021/jo010707j

  日期：2002.1.1

  two reactive positions with lithium di-tert-butyl-(2,2,6,6-tetramethylpiperidino)zincate. 5,5'-Dibromo-2,2'-bipyridine was obtained by the reductive symmetric coupling of 2,5-dibromopyridine with hexa-n-butyldistannane. The yields of these coupling reactions ranged from 70 to 90%. 5-Bromo- and 5,5'-dibromo-2,2'-bipyrimidines were obtained in yields of 30 and 15%, respectively, by bromination of 2,2'-bipyrimidine

  已经开发了可用于制备金属络合物分子棒的5-溴和5,5'-二溴的2,2'-联吡啶和2,2'-联嘧啶的有效合成方法。通过以下方法获得了5-溴-2,2'-联吡啶，5-溴-5'-正丁基-2,2'-联吡啶和5-溴-5'-正己基-2,2'-联吡啶2，5-二溴吡啶与2-三甲基苯乙烯基吡啶或必要的5-烷基-2-三甲基苯乙烯基吡啶的斯蒂勒偶联，是通过3-烷基吡啶.BF（3）络合物的区域选择性锌化而获得的，该络合物在较少受两个反应位置影响的情况下与二锂-叔丁基-（2,2,6,6-四甲基哌啶子基）锌酸酯。通过5，5′-二溴-2，2′-联吡啶通过2，5-二溴吡啶与六正丁基二锡烷的还原对称偶联而获得。这些偶联反应的产率为70-90％。
• Iron catalyzed cross coupling reactions of aromatic compounds
  申请人：——

  公开号：US20030220498A1

  公开（公告）日：2003-11-27

  A process for the production of compounds Ar—R 1 by means of a cross-coupling reaction of an organometallic reagent R 1 —M with an aromatic or heteroaromatic substrate Ar—X catalyzed by one or several iron salts or iron complexes as catalysts or pre-catalysts, present homogeneously or heterogeneously in the reaction mixture. This new invention exhibits substantial advantages over established cross coupling methodology using palladium- or nickel complexes as the catalysts. Most notable aspects are the fact that (i) expensive and/or toxic nobel metal catalysts are replaced by cheap, stable, commercially available and toxicologically benign iron salts or iron complexes as the catalysts or pre-catalysts, (ii) commercially attractive aryl chlorides as well as various aryl sulfonates can be used as starting materials, (iii) the reaction can be performed under “ligand-free” conditons, and (iv) the reaction times are usually very short.

  通过使用一种或多种铁盐或铁络合物作为催化剂或前催化剂，在有机金属试剂R1—M与芳香或杂芳底物Ar—X之间进行交叉偶联反应的方法，生产化合物Ar—R1。这一新发明相对于使用钯或镍络合物作为催化剂的传统交叉偶联方法具有显著优势。最值得注意的方面包括：(i) 昂贵和/或有毒的贵金属催化剂被廉价、稳定、商业可获得且毒理学上良性的铁盐或铁络合物替代作为催化剂或前催化剂，(ii) 商业上具吸引力的芳基氯化物以及各种芳基磺酸盐可用作起始材料，(iii) 反应可在“无配体”条件下进行，(iv) 反应时间通常非常短。