(1R,5S,6S)-7,7-dichloro-2-(2,4-dimethoxybenzyl)-5-methyl-2-azabicyclo[4.1.0]heptan-3-one | 1393682-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1R,5S,6S)-7,7-dichloro-2-(2,4-dimethoxybenzyl)-5-methyl-2-azabicyclo[4.1.0]heptan-3-one
• 英文别名: (1R,5S,6S)-7,7-dichloro-2-[(2,4-dimethoxyphenyl)methyl]-5-methyl-2-azabicyclo[4.1.0]heptan-3-one
• CAS: 1393682-17-1
• 化学式: C₁₆H₁₉Cl₂NO₃
• 分子量: 344.238
• InChiKey: PMVSEBJQHAMODB-ULKVUYOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氯仿 、 (4S)-1-(2,4-dimethoxybenzyl)-4-methyl-3,4-dihydropyridin-2(1H)-one 在 tricaprylylmethyl ammoniumchloride 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 22.0h， 以45%的产率得到(1S,5S,6R)-7,7-dichloro-2-(2,4-dimethoxybenzyl)-5-methyl-2-azabicyclo[4.1.0]heptan-3-one
  参考文献：
  名称：

  New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714

  摘要：

  In an experimental permanent stroke model, we report here the contribution of ONO-1714 to brain damage prevention. Daily drug administration, twenty-one days prior to and two days after an experimental infarct, was performed by using mini-osmotic pumps (ALZET). Infarct volumes were assessed by image analysis of sequential corona] brain 1 mm(3) sections stained following the 2,3,5-triphenyltetrazolium chloride histological staining technique. Results of this study provide evidence of a significant reduction of the brain lesion size, suggesting ONO-1714 as a potential neuroprotective agent in stroke patients. ONO-1714 was prepared in our laboratory following a procedure which resulted in the supply of the desired compound in an easy and excellent yield. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.05.031

文献信息

• New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714
  作者：Andrea Pozo-Rodrigálvarez、Ana Gradillas、Julia Serrano、Ana Patricia Fernández、Ricardo Martínez-Murillo、Javier Pérez-Castells

  DOI：10.1016/j.ejmech.2012.05.031

  日期：2012.8

  In an experimental permanent stroke model, we report here the contribution of ONO-1714 to brain damage prevention. Daily drug administration, twenty-one days prior to and two days after an experimental infarct, was performed by using mini-osmotic pumps (ALZET). Infarct volumes were assessed by image analysis of sequential corona] brain 1 mm(3) sections stained following the 2,3,5-triphenyltetrazolium chloride histological staining technique. Results of this study provide evidence of a significant reduction of the brain lesion size, suggesting ONO-1714 as a potential neuroprotective agent in stroke patients. ONO-1714 was prepared in our laboratory following a procedure which resulted in the supply of the desired compound in an easy and excellent yield. (C) 2012 Elsevier Masson SAS. All rights reserved.