sodium 3-piperidinopropanolate | 462115-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: sodium 3-piperidinopropanolate
• 英文别名: sodium;3-piperidin-1-ylpropan-1-olate
• CAS: 462115-38-4
• 化学式: C₈H₁₆NO*Na
• 分子量: 165.211
• InChiKey: VCBSCJXWLSZOFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.77
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  sodium 3-piperidinopropanolate 、 3-(4-chlorophenyl)propyl methanesulfonate 在 15-冠醚-5 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以75%的产率得到Pitolisant; 1-[3-[3-(4-氯苯基)丙氧基]丙基]哌啶
  参考文献：
  名称：

  WO2006/84833

  摘要：

  公开号：

文献信息

• Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications
  申请人：——

  公开号：US20040220225A1

  公开（公告）日：2004-11-04

  Use of a compound of formula (A), wherein: 1 W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用式(A)的化合物，其中：1W是一个残基，当附加在咪唑环的4(5)位时，赋予组合物在组胺H3受体上的拮抗和/或激动活性；R1和R2可以相同也可以不同，分别独立地表示较低的烷基或环烷基，或者与它们所连接的氮原子一起，表示饱和的含氮环(i)、非芳香性不饱和含氮环(ii)、吗啡环或N-取代哌嗪环，用于制备在组胺H3受体上作为拮抗剂和/或激动剂的药物。
• Non-imidazole alkylamines as histamine H3- receptor ligands and their therapeutic applications
  申请人：Schwartz Jean-Charles

  公开号：US20060247223A1

  公开（公告）日：2006-11-02

  Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用公式（A）中的化合物，其中： W是一个残留物，当附加到咪唑环的4（5）位时，赋予组织胺H3受体的拮抗和/或激动活性； R1和R2可以相同也可以不同，并且独立地表示较低的烷基或环烷基，或者与它们附着的氮原子一起，表示饱和的含氮环（i）如定义，非芳香性不饱和含氮环（ii）如定义，吗啉基或N-取代的哌嗪基，如定义，用于制备作为组织胺H3受体的拮抗剂和/或激动剂的药物。
• Monohydrochloride Salt of 1-[3-[3-(4-Chlorophenyl) Propoxy] Propyl] -Piperidine
  申请人：Raga Manuel

  公开号：US20080221162A1

  公开（公告）日：2008-09-11

  The invention relates to new crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride, the respective manufacture and methods of use, and compositions containing such a compound.

  本发明涉及新的晶体1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶单盐酸盐，其制造方法和使用方法，以及含有该化合物的组合物。
• MONOHYDROCHLORIDE SALT OF 1-[3-[3-(4-CHLOROPHENYL) PROPOXY]PROPYL]-PIPERIDINE
  申请人：RAGA Manuel

  公开号：US20120289546A1

  公开（公告）日：2012-11-15

  A method is provided for the treatment of sleep apnea and other conditions wherein an effective amount of crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride of formula (I): optionally comprising water up to 6%, and having an X-ray diffractogram that comprises characteristic peaks (2θ) at 11.2°, 19.9°, 20.7° and 34.1°±0.2° is administered to a patient in need thereof.

  提供了一种治疗睡眠呼吸暂停和其他病症的方法，其中向需要治疗的患者给予公式(I)的晶体1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶单盐酸盐的有效量：可选地含水高达6％，并且具有X射线衍射图谱，其中包括在11.2°，19.9°，20.7°和34.1°±0.2°处的特征峰。
• NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：SCHWARTZ Jean-Charles

  公开号：US20110281844A1

  公开（公告）日：2011-11-17

  Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用公式（A）中的化合物，其中： W是一个残基，当连接到咪唑环的4（5）位置时，赋予组合物在组胺H3受体上的拮抗和/或激动活性；R1和R2可能相同也可能不同，且分别独立地代表较低的烷基或环烷基，或者与它们连接的氮原子一起，代表饱和的含氮环（i），如所定义，非芳香性不饱和含氮环（ii），如所定义，吗啡啶基团，或所定义的N-取代哌嗪基团，以制备在组胺H3受体上作为拮抗剂和/或激动剂的药物。