N,N-diisopropylmethylphosphonamidic chloride | 125348-17-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: N,N-diisopropylmethylphosphonamidic chloride
• 英文别名: N,N-diisopropylmethylphosphoamidic chloride；N-[chloro(methoxy)phosphoryl]-N-propan-2-ylpropan-2-amine
• CAS: 125348-17-6
• 化学式: C₇H₁₇ClNO₂P
• 分子量: 213.644
• InChiKey: INHNKJCTPMGXBD-UHFFFAOYSA-N

物化性质

• 沸点：
  230.2±23.0 °C(Predicted)
• 密度：
  1.101±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  雄诺龙 、 N,N-diisopropylmethylphosphonamidic chloride 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 N,N-diisopropylmethylphoshoramidate of DHT
  参考文献：
  名称：

  Cancer specific radiolabeled conjugates regulated by the cell cycle for the treatment and diagnosis of cancer

  摘要：

  揭示了具有一种有效靶向肿瘤细胞的成分的放射性标记结合物，这些细胞选择性地吸收和降解结合物，从而将能够被核物质吸收的放射性同位素传递至肿瘤细胞核，以产生细胞毒作用和/或使细胞可通过放射成像检测。

  公开号：

  US20050069495A1

文献信息

• [EN] NOVEL ANTIMICROBIAL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS ANTIMICROBIENS
  申请人：ADELAIDE RES & INNOVATION PTY

  公开号：WO2013040647A1

  公开（公告）日：2013-03-28

  A new class of biotin protein ligase (BPL) inhibitors that have antibacterial activity against multiple Staphylococcus aureus isolates, including clinically important methicillin-resistant S. aureus (MRSA) are disclosed that are non-toxic.

  披萨店的招牌菜是各种口味的披萨，包括经典的意大利香肠披萨、夏威夷披萨、墨西哥辣椒披萨等。
• NOVEL ANTIMICROBIAL COMPOUNDS
  申请人：MONASH UNIVERSITY

  公开号：US20140296177A1

  公开（公告）日：2014-10-02

  A new class of biotin protein ligase (BPL) inhibitors that have antibacterial activity against multiple Staphylococcus aureus isolates, including clinically important methicillin-resistant S. aureus (MRSA) are disclosed that are non-toxic.

  披露了一种新型生物素蛋白连接酶（BPL）抑制剂，对包括临床重要的甲氧西林耐药金黄色葡萄球菌（MRSA）在内的多种金黄色葡萄球菌具有抗菌活性，并且是无毒的。
• Synthesis, annealing properties, fluorine-19 NMR characterization, and detection limits of a trifluorothymidine-labeled antisense oligodeoxyribonucleotide 21 mer'
  作者：William H. Gmeiner、Richard T. Pon、J. William Lown

  DOI：10.1021/jo00011a028

  日期：1991.5

  The synthesis and characterization are described of trifluorothymidine groups incorporated into an antisense 21 mer designed to target gene sequences that encode serine proteases in T-lymphocytes. H-1 NMR titration studies on 3',5'-O-TPDS-trifluorothymidine (3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)trifluorothymidine) with 3',5'-O-TPDS-2'-deoxyadenosine provided clear evidence of normal Watson-Crick base pairing via detection of the imino proton signals. The chemical shift of the imino proton is moved ca. 0.5 ppm upfield relative to the position with the natural nucleoside. H-1 NMR also confirmed normal annealing in the 21 mer with its complement in the imino proton detection with the most notable difference being that six AT signals move upfield into the region characteristic of Watson-Crick GC base pairs. 1D-NMR experiments confirm that a single species exists in solution and CD studies indicate that the duplex formed with its complement adopts B-form geometry. The 1D-NMR experiments show that two of three ordinary methyl groups in the hybrid duplex exist in a single conformation while the third methyl group is predominantly in a single conformation. Molecular modeling of the duplex formed between the trifluorothymidine antisense sequence and complementary mRNA indicates a stable A-type helix in which the CF3 groups cause the thymidine base pairs to be displaced somewhat compared with the natural structure. The limits of F-19 NMR detection of the trifluorothymidine labeled 21 mer were determined to be ca. 10-mu-M at a 10:1 signal to noise ratio, i.e., satisfactory for projected in vivo NMR imaging studies.
• Glycerophosphoric acid ester derivative having polyfunctional metal chelate structure
  申请人：Fujifilm Corporation

  公开号：EP1795208B1

  公开（公告）日：2011-07-27
• US9108978B2
  申请人：——

  公开号：US9108978B2

  公开（公告）日：2015-08-18