4-({4-[bis(4-(trifluoromethoxy)phenyl)hydroxymethyl]piperidinyl}methyl)benzaldehyde | 183992-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-({4-[bis(4-(trifluoromethoxy)phenyl)hydroxymethyl]piperidinyl}methyl)benzaldehyde
• 英文别名: N-[4-formylphenylmethyl]4-[bis(4-trifluoromethoxyphenyl)hydroxymethyl]piperidine；4-[[4-[Hydroxy-bis[4-(trifluoromethoxy)phenyl]methyl]piperidin-1-yl]methyl]benzaldehyde
• CAS: 183992-28-1
• 化学式: C₂₈H₂₅F₆NO₄
• 分子量: 553.501
• InChiKey: OMJNPRSZMQSAEF-UHFFFAOYSA-N

物化性质

• 沸点：
  570.6±50.0 °C(Predicted)
• 密度：
  1.356±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  1,2-丙二醇 、 4-({4-[bis(4-(trifluoromethoxy)phenyl)hydroxymethyl]piperidinyl}methyl)benzaldehyde 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 16.0h， 生成 bis[4-(trifluoromethoxy)-phenyl](1-{[(4-(4-methyl(1,3-dioxolan-2-yl))phenyl)]methyl}(4-piperidyl))methan-1-ol
  参考文献：
  名称：

  WO2006/65659

  摘要：

  公开号：

文献信息

• Insecticidal oximino and hydrazono derivatives of
  申请人：FMC Corporation

  公开号：US05939438A1

  公开（公告）日：1999-08-17

  It has now been found that certain novel oximino and hydrazono derivatives of N-benzyl-4-benzhydryl- and 4-benhydrolpiperidines, and their corresponding N-oxides and agriculturally acceptable salts are useful as insecticides. These compounds are represented by Formula I: where R is hydrogen, halogen, alkyl, alkoxy, dialkylamino; R.sup.1 is hydrogen, alkyl, haloalkyl, alkoxyalkyl, alkylcarbonyl and alkylaminocarbonyl; X is oxygen, or NR.sup.2, Q is fluoro and hydroxy; Z is halogen, haloalkyl, haloalkoxy, pentahalothio, haloalkylthio, haloalkylsulfinyl, haloalkylsulfonyl, and --OCF.sub.2 O-- attached to two adjacent carbon atoms of the phenyl ring; n is 0 or 1; and, when X is NR.sup.2, R.sup.2 is hydrogen, alkyl, alkylcarbonyl, alkoxycarbonyl, or R.sup.1 and R.sup.2 taken together may be --C.sub.m H.sub.2.spsb.m, or --C.sub.2 H.sub.4 OC.sub.2 H.sub.4 --, where m is 3-9. Preferred compounds include those where R is hydrogen; R.sup.1 is alkyl; Q is hydroxy; X is oxygen; and Z is trifluoromethyl or trifluoromethoxy.

  已经发现，N-苄基-4-苄基二苯甲基-和4-苄基羟基哌啶的某些新颖的氧肟和肼肟衍生物，以及它们相应的N-氧化物和农业可接受的盐可用作杀虫剂。这些化合物由式I表示：其中R为氢、卤素、烷基、烷氧基、二烷基胺基；R.sup.1为氢、烷基、卤代烷基、烷氧基烷基、烷基羰基和烷基氨基羰基；X为氧或NR.sup.2，Q为氟和羟基；Z为卤素、卤代烷基、卤代烷氧基、五卤硫、卤代烷硫基、卤代烷基磺酰基、卤代烷基磺基和连接到苯环的两个相邻碳原子的--OCF.sub.2 O--；n为0或1；当X为NR.sup.2时，R.sup.2为氢、烷基、烷基羰基、烷氧基羰基，或R.sup.1和R.sup.2一起可以是--C.sub.m H.sub.2.spsb.m，或--C.sub.2 H.sub.4 OC.sub.2 H.sub.4--，其中m为3-9。优选的化合物包括R为氢；R.sup.1为烷基；Q为羟基；X为氧；Z为三氟甲基或三氟甲氧基。
• INSECTICIDAL BIS(SUBSTITUTED PHENYL)-1-{[4-(SATURATED HETEROCYCLYL-SUBSTITUTED)PHENYLMETHYL]- (4-PIPERIDYL)}METHANE DERIVATIVES
  申请人：Lyga John W.

  公开号：US20090082203A1

  公开（公告）日：2009-03-26

  It has now been found that certain novel bis(substituted phenyl)-1 [4-(saturated heterocyclyl-substituted)phenyl-methyl](4-piperidyl)}methane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I); where R through R 15 , m, n, s, A, B, D and W are defined herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现在已经发现，某些新型的双（取代苯基）-1 [4-（饱和杂环取代）苯基甲基](4-哌啶基)}甲烷衍生物提供了意想不到的杀虫活性。这些化合物由式（I）表示; 其中R到R15，m，n，s，A，B，D和W在此定义。此外，本文还披露了包含式（I）中至少一种化合物的杀虫有效量和可选地至少一种第二化合物的有效量的组合物，其中至少包含一种杀虫剂兼容载体; 以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的地点。
• EP1828127A4
  申请人：——

  公开号：EP1828127A4

  公开（公告）日：2009-04-29
• INSECTICIDAL BIS(SUBSTITUTED PHENYL)-1-äÝ4-(SATURATED HETEROCYCLYL-SUBSTITUTED)PHENYLMETHYL¨-(4-PIPERIDYL)üMETHANE DERIVATIVES
  申请人：BAYER CROPSCIENCE AG

  公开号：EP1828127A2

  公开（公告）日：2007-09-05
• US5939438A
  申请人：——

  公开号：US5939438A

  公开（公告）日：1999-08-17