2,2,6,6-tetramethyl-3-bromo-4-oxo-1-hydroxypiperidine | 81635-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,2,6,6-tetramethyl-3-bromo-4-oxo-1-hydroxypiperidine
• 英文别名: 3-Bromo-1-hydroxy-2,2,6,6-tetramethylpiperidin-4-one
• CAS: 81635-36-1
• 化学式: C₉H₁₆BrNO₂
• 分子量: 250.136
• InChiKey: DGZFWZMBZUTPGD-UHFFFAOYSA-N

物化性质

• 沸点：
  303.4±42.0 °C(Predicted)
• 密度：
  1.372±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  13.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  40.54
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2,2,6,6-tetramethyl-3-bromo-4-oxo-1-hydroxypiperidine 在 ammonium hydroxide 作用下， 生成 2,6-dimethyl-2-nitrosohept-5-en-4-one
  参考文献：
  名称：

  The effect of the nature of the substituent at the nitrogen atom on transformations of 3-bromo-2,2,6,6-tetramethyl-4-piperidinone and its 1-hydroxy and 1-oxyl derivatives under conditions of the Favorsky rearrangement

  摘要：

  3-Bromo-2,2,6,6-tetramethyl-4-oxopiperidine-1-oxyl reacts with NH4OH to give 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl, a product of the Favorsky rearrangement. 3-Bromo-2,2,6,6-tetramethyl-4-piperidinone is transformed under these conditions into a bicyclic amino ketone, while its 1-hydroxy derivative affords acyclic nitrosoenone.

  DOI：

  10.1007/bf02496215
• 作为产物：
  描述：

  1-羟基-2,2,6,6-四甲基-4-哌啶酮盐酸盐(1:1) 在 溴 作用下， 以 氯仿 为溶剂， 生成 2,2,6,6-tetramethyl-3-bromo-4-oxo-1-hydroxypiperidine
  参考文献：
  名称：

  Oxidation of di-tert-alkylhydroxylamines to nitroxide radicals by nitrous acid

  摘要：

  DOI：

  10.1007/bf00957948

文献信息

• Targeted delivery of imaging probes for in vivo cellular imaging
  申请人：Kao Joseph P. Y.

  公开号：US10202342B2

  公开（公告）日：2019-02-12

  The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching concentrations thereof, wherein the liposomes optionally comprise a targeting ligand specific to and having affinity for targeted tissue.

  本发明涉及的是同位素改性的或未改性的硝基氧成像探针。这样的硝基氧成像探针可以包含在封装了自猝灭浓度硝基氧的脂质体中，其中脂质体可选地包含一种针对目标组织具有特异性和亲和力的靶向配体。
• HYDROXYLAMINE COMPOUNDS AND METHODS OF THEIR USE
  申请人：Patil Ghanshyam

  公开号：US20080280890A1

  公开（公告）日：2008-11-13

  The present disclosure provides compounds that include hydroxylamines of formula I or II, pharmaceutical compositions, and methods for their use. The methods utilize hydroxylamine compounds and/or their pharmaceutical compositions for the treatment of angiogenesis, hepatitis, complement-mediated pathologies, drusen-mediated pathologies, macular degeneration and certain other ophthalmic conditions, inflammation, arthritis, and related diseases and for the inhibition of complement activation.

  本公开提供了包括式I或II的羟胺化合物、制药组合物以及它们的使用方法。该方法利用羟胺化合物及/或其制药组合物治疗血管生成、肝炎、补体介导的病理、色斑介导的病理、黄斑变性和某些其他眼科疾病、炎症、关节炎和相关疾病，并抑制补体激活。
• Hydroxylamine compounds and methods of their use
  申请人：Colby Pharmaceutical Company

  公开号：EP2620429A1

  公开（公告）日：2013-07-31

  The present disclosure provides compounds that include hydroxylamines of formula I or II, pharmaceutical compositions, and methods for their use. The methods utilize hydroxylamine compounds and/or their pharmaceutical compositions for the treatment of angiogenesis, hepatitis, complement-mediated pathologies, drusen-mediated pathologies, macular degeneration and certain other ophthalmic conditions, inflammation, arthritis, and related diseases and for the inhibition of complement activation.

  本公开提供了包括式 I 或式 II 的羟胺化合物、药物组合物及其使用方法。这些方法利用羟胺化合物和/或其药物组合物治疗血管生成、肝炎、补体介导的病变、褐斑介导的病变、黄斑变性和某些其他眼科疾病、炎症、关节炎和相关疾病以及抑制补体活化。
• Dikanov, S. A.; Grigor'ev, I. A.; Volodarskii, L. B., Russian Journal of Physical Chemistry, 1982, vol. 56, # 11, p. 1696 - 1699
  作者：Dikanov, S. A.、Grigor'ev, I. A.、Volodarskii, L. B.、Tsvetkov, Yu. D.

  DOI：——

  日期：——
• 3-Monohalo derivatives of triacetoneamine, 1-hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine, and 2,2,6,6-tetramethyl-4-oxopiperidin-1-oxyl
  作者：L. A. Krinitskaya、L. B. Volodarskii

  DOI：10.1007/bf00948269

  日期：1982.2