3-(2-fluorophenyl)-1-methyl-4-piperidone | 76041-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(2-fluorophenyl)-1-methyl-4-piperidone
• 英文别名: 3-o-fluorophenyl-1-methyl-4-piperidone；3-(2-Fluorophenyl)-1-methylpiperidin-4-one
• CAS: 76041-40-2
• 化学式: C₁₂H₁₄FNO
• 分子量: 207.248
• InChiKey: SIJPLQXFVASQBQ-UHFFFAOYSA-N

物化性质

• 沸点：
  301.1±42.0 °C(Predicted)
• 密度：
  1.136±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-fluorophenyl)-1-methyl-4-piperidone 生成 (3S,4R)-3-(2-fluorophenyl)-1-methyl-4-phenylpiperidin-4-ol
  参考文献：
  名称：

  KLIOZE, S. S.

  摘要：

  DOI：

文献信息

• Antidepressive and analgesic 4-aryloxy- and
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US04312876A1

  公开（公告）日：1982-01-26

  Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.

  描述了新型4-芳氧基和4-芳硫基-3-苯基哌啶和相关化合物，其生理上可接受的盐及其中间体，具有镇痛、抗抑郁性能，并提供了制备这些化合物、衍生物和中间体的方法。
• Antidepressant and analgesic 4-aryloxy- and
  申请人：American Hoechst Corporation

  公开号：US04216218A1

  公开（公告）日：1980-08-05

  Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.

  描述了新型4-芳氧基和4-芳硫基-3-苯基哌啶类化合物及其生理上可接受的盐和中间体，具有镇痛、抗抑郁特性，并提供了制备这类化合物、衍生物和中间体的方法。
• cis-4a-Aryl-1,2,3,4,4a,9b-hexahydro-benzofuro[3,2-c]pyridines and their
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04507306A1

  公开（公告）日：1985-03-26

  cis-4a-Aryl-1,2,3,4,4a,9b-hexahydro-benzofuro[3,2-c]pyridines and methods of preparing same are described. On the nitrogen atom there may be a substituent including loweralkyl, loweralkenyl, phenylloweralkyl, hydrogen, cyanoloweralkyl, phenylcarbonylloweralkyl, phenoxyloweralkyl and cycloalkylloweralkyl. The 4a-aryl group may be a phenyl, mono-halogen substituted phenyl, tolyl, methoxyphenyl, hydroxyphenyl, or furyl. These compounds are useful as analgesic and anticonvulsant agents. 3-o-Fluorophenyl-1-methyl-4-aryl-4-piperidinols which are useful as intermediates for preparing the aforementioned compounds and methods for preparing same are also described.

  描述了cis-4a-芳基-1,2,3,4,4a,9b-六氢-苯并噻喃[3,2-c]吡啶类化合物及其制备方法。在氮原子上可能存在取代基，包括低烷基、低烯基、苯基低烷基、氢、氰基低烷基、苯基羰基低烷基、苯氧基低烷基和环烷基低烷基。4a-芳基可能是苯基、单卤素取代的苯基、甲苯基、甲氧基苯基、羟基苯基或呋喃基。这些化合物可用作镇痛和抗惊厥剂。还描述了作为制备上述化合物的中间体的3-氟苯基-1-甲基-4-芳基-4-哌啶醇以及制备方法。
• Cis- and
  申请人：Hoechst-Roussel Pharmaceuticals, Inc.

  公开号：US04382141A1

  公开（公告）日：1983-05-03

  Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.

  本发明涉及4-芳氧基和4-芳硫基-3-苯基哌啶及其相关化合物，其生理上可接受的盐和中间体，具有镇痛、抗抑郁特性，以及制备这种化合物、衍生物和中间体的方法。
• Process for preparing 4-aryloxy-3-phenylpiperidines
  申请人：Hoechst-Roussel Pharmaceuticals, Inc.

  公开号：US04424357A1

  公开（公告）日：1984-01-03

  Novel 4-aryloxy- and 4-arylthio-3-phenylpiperidines and related compounds, physiologically acceptable salts thereof and intermediates therefor possessing analgesic, antidepressant properties, and a process for the preparation of such compounds, derivatives and intermediates are described.

  本发明涉及一种新型的4-芳氧基和4-芳硫基-3-苯基哌啶类化合物及其相关衍生物、生理学上可接受的盐和中间体，具有镇痛、抗抑郁性能，以及制备此类化合物、衍生物和中间体的方法。