5-cyclohexyl-2-methylthiophene | 1242676-11-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-cyclohexyl-2-methylthiophene
• 英文别名: 2-Cyclohexyl-5-methylthiophene
• CAS: 1242676-11-4
• 化学式: C₁₁H₁₆S
• 分子量: 180.314
• InChiKey: PPMVMTUNROTUPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基噻吩 、 溴代环己烷 在 iron(III) chloride 、 TMPMgCl*LiCl 、 (1S,2S)-(+)-N,N'-二甲基环己烷-1,2-二胺 作用下， 以 四氢呋喃 为溶剂， 以44%的产率得到5-cyclohexyl-2-methylthiophene
  参考文献：
  名称：

  铁催化的杂环和芳烃去质子烷基化

  摘要：

  已经开发了一种通过烷基碘和溴对芳烃 C-H 键进行铁催化去质子烷基化的方法。在酰胺碱的存在下，伯和仲烷基卤化物都可以与呋喃、噻吩、吡啶衍生物和一些含吸电子基团的芳烃偶联。

  DOI：

  10.1021/ol101684u

文献信息

• COELENTERAZINE ANALOGUES
  申请人：PROMEGA CORPORATION

  公开号：US20170233789A1

  公开（公告）日：2017-08-17

  Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

  本发明涉及荧光素类似物，制备该类似物的方法，包含该类似物的试剂盒，以及使用该化合物进行基于荧光素酶的检测中发光的方法。
• T-TYPE CALCIUM CHANNEL INHIBITOR
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20160237071A1

  公开（公告）日：2016-08-18

  A novel compound that has an excellent T-type calcium channel inhibitory activity and is specifically useful for prevention or treatment of pain, chronic kidney disease and atrial fibrillation. The novel triazinone compound of Formula (I): where each substituent in the formula is defined in detail in the description, and R 1 could be a hydrogen atom, or a C 1-6 alkyl group, etc., E could be a 7 to 14-membered non-aromatic fused heterocyclic group, L 3 could be a C 1-6 alkylene group, etc., D could be a C 6-14 aryl group or a 5 to 10-membered heteroaryl group each of which is optionally substituted, etc., a tautomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

  一种新型化合物，具有出色的T型钙通道抑制活性，特别适用于预防或治疗疼痛、慢性肾脏疾病和心房颤动。该新型三嗪酮化合物的化学式为（I），其中公式中的每个取代基在描述中都有详细定义，R1可以是氢原子或C1-6烷基等，E可以是7-14个成员的非芳香融合杂环基，L3可以是C1-6亚烷基等，D可以是C6-14芳基或5-10个成员的杂环芳基，每个基团都可以有选择性地取代等，该化合物的互变异构体或药学上可接受的盐或溶剂化物。
• AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1057812A1

  公开（公告）日：2000-12-06

  The present invention is to provide a compound of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optionally substituted 5- to 6-membered aromatic heterocyclic ring, R1 is a hydrogen atom, a hydroxy group or a lower alkyl group, and n is 0 or 1, or a salt thereof, which is effective for the prevention or treatment of ischemic cardiac disease, etc., and which is useful as preventing or treating agent for ischemic cardiac disease, etc. such as myocardial infarction, arrhythmia, etc.

  本发明旨在提供一种式化合物： 其中环A为任选取代的5-6元芳香杂环，环B为任选取代的5-6元芳香均环或任选取代的5-6元芳香杂环，R1为氢原子、羟基或低级烷基，n为0或1，或其盐，可有效预防或治疗缺血性心脏病等、可用作心肌梗塞、心律失常等缺血性心脏病的预防或治疗剂。
• [EN] COELENTERAZINE ANALOGUES<br/>[FR] ANALOGUES DE COELENTÉRAZINE
  申请人：PROMEGA CORP

  公开号：WO2017142852A1

  公开（公告）日：2017-08-24

  Described are coelenterazine analogues of formula (I), methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
• Iron-Catalyzed Heterocycle and Arene Deprotonative Alkylation
  作者：Ly Dieu Tran、Olafs Daugulis

  DOI：10.1021/ol101684u

  日期：2010.10.1

  A method for iron-catalyzed deprotonative alkylation of arene C−H bonds by alkyl iodides and bromides has been developed. In the presence of an amide base, both primary and secondary alkyl halides can be coupled with furans, thiophenes, pyridine derivatives, and some electron-withdrawing-group containing arenes.

  已经开发了一种通过烷基碘和溴对芳烃 C-H 键进行铁催化去质子烷基化的方法。在酰胺碱的存在下，伯和仲烷基卤化物都可以与呋喃、噻吩、吡啶衍生物和一些含吸电子基团的芳烃偶联。