N-[4-methoxy-3-[[(2-phenylpiperidin-3-yl)amino]methyl]phenyl]-N-methylmethanesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-[4-methoxy-3-[[(2-phenylpiperidin-3-yl)amino]methyl]phenyl]-N-methylmethanesulfonamide
• 化学式: C₂₁H₂₉N₃O₃S
• 分子量: 403.5
• InChiKey: GZLOIBNBDUHEFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  79
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Substituted benzylamino nitrogen containing non-aromatic heterocycles
  申请人：PFIZER INC.

  公开号：EP1114823A2

  公开（公告）日：2001-07-11

  The present invention relates to novel substituted benzylamino nitrogen containing nonaromatic heterocycles and, specifically, to compounds of formula (I) wherein W, R1, R2, R3 and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula (I) are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

  本发明涉及新型取代的含苄基氨基氮的非芳香族杂环，特别是涉及式（I）化合物（其中 W、R1、R2、R3 和 A 如说明书中所定义）以及用于合成此类化合物的中间体。式（I）的新型化合物可用于治疗炎症和中枢神经系统疾病以及其他疾病。
• SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES
  申请人：PFIZER INC.

  公开号：EP0655996B1

  公开（公告）日：2001-11-07
• [EN] SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES<br/>[FR] BENZYLAMINO AZOTE SUBSTITUE RENFERMANT DES HETEROCYCLES NON AROMATIQUES
  申请人：——

  公开号：WO1994004496A1

  公开（公告）日：1994-03-03

  [EN] The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of formula (I) wherein W, R1, R2, R3 and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula (I) are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
  [FR] La présente invention concerne un nouveau benzylamino azote substitué contenant des hétérocycles non aromatiques et, plus précisément, des composés de la formule (I) dans laquelle W, R1, R2, R3 et A sont tels que définis dans la description, ainsi que des intermédiaires utilisés dans la synthèse de tels composés. Ces nouveaux composés de formule (I) sont utiles dans le traitement de troubles inflammatoires et du système nerveux central, ainsi que d'autres troubles.