7,8-Dihydro-8-thioxo-5a(2)-guanylic acid | 56883-53-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 7,8-Dihydro-8-thioxo-5a(2)-guanylic acid
• 英文别名: [(2R,3S,4R,5R)-5-(2-amino-6-oxo-8-sulfanylidene-1,7-dihydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• CAS: 56883-53-5
• 化学式: C₁₀H₁₄N₅O₈PS
• 分子量: 395.29
• InChiKey: YEGJZZYBWKRNEC-UMMCILCDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  231
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING REDOX-SENSITIVE GTPASES
  申请人：Heo Jongyun

  公开号：US20120171302A1

  公开（公告）日：2012-07-05

  The invention provides compositions for inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, comprising an effective amount of a redox-sensitive purine compound and an effective amount of a redox agent. The invention further provides methods of inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, by administering compositions of the invention. Methods of screening for compounds that inhibit a redox-sensitive GTPase protein, including compounds that target and inhibit Rho or Rab family GTPases, are further provided.
• US8729047B2
  申请人：——

  公开号：US8729047B2

  公开（公告）日：2014-05-20
• US9301960B2
  申请人：——

  公开号：US9301960B2

  公开（公告）日：2016-04-05