dichlorobis(methyldiphenylsilyl)methane | 383180-56-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: dichlorobis(methyldiphenylsilyl)methane
• 英文别名: [Dichloro-[methyl(diphenyl)silyl]methyl]-methyl-diphenylsilane
• CAS: 383180-56-1
• 化学式: C₂₇H₂₆Cl₂Si₂
• 分子量: 477.58
• InChiKey: XYUMGCMPDQTQDH-UHFFFAOYSA-N

物化性质

• 沸点：
  477.2±45.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.02
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dichlorobis(methyldiphenylsilyl)methane 在 正丁基锂 、 silica gel 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.83h， 生成 1-(methyldiphenylsilyl)-2-buten-1-one
  参考文献：
  名称：

  通过对二硅烷基烷基铜化合物的好氧氧化，可轻松合成酰基硅烷。

  摘要：

  DOI：

  10.1021/ja016716r
• 作为产物：
  描述：

  二氯甲烷 、 甲基二苯基氯硅烷 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以85%的产率得到dichlorobis(methyldiphenylsilyl)methane
  参考文献：
  名称：

  Preparation of α-silyl- or α,α-bis(silyl)-substituted alkylcopper reagents and their synthetic use

  摘要：

  Treatment of chlorobis(methyldiphenylsilyl)methyllithium with various alkyl and aryl Grignard reagents and CuCN center dot 2LiCl afforded 1,1-disilylalkylcopper species. The aerobic oxidation of the resulting copper reagents provided a variety of acylsilanes in good yields. Meanwhile, treatment of dichloro(methyldiphenylsilyl)methyllithum with Bu2CuLi center dot LiCN provided 1-cyano-1-silylalkylcopper species via consecutive double 1,2-migration of alkyl and cyano groups. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.01.101

文献信息

• Generation and regioselective reactions of α,α-bis(silyl)-substituted allylcopper reagents—synthesis of 1,1-disilylalkenes
  作者：Junichi Kondo、Atsushi Inoue、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1016/s0040-4039(02)00259-9

  日期：2002.3

  Treatment of chlorobis(methyldiphenylsilyl)methyllithium with vinylic Grignard reagents and CuCN·2LiCl afforded α,α-bis(silyl)-substituted allylic copper species. The reactions of the reagents with electrophiles provided a variety of 1,1-disilylalkenes.

  用乙烯基格氏试剂和CuCN·2LiCl处理氯代双（甲基二苯基甲硅烷基）甲基锂，得到α，α-双（甲硅烷基）取代的烯丙基铜。试剂与亲电试剂的反应提供了各种1,1-二甲硅烷基烯烃。
• 1,2-Migration of Phosphorus-Centered Anions on Ate-type Copper Carbenoids and Its Application for the Synthesis of New Potent Phosphine Ligands
  作者：Junichi Kondo、Hidenori Someya、Hidenori Kinoshita、Hiroshi Shinokubo、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1021/ol052520a

  日期：2005.12.1

  Diorganophosphide anions, which usually function as nontransferable ligands on mixed cuprates, undergo smooth 1,2-migration on ate-type copper carbenoids. Phosphinodisilylmethylcoppers prepared by this protocol are converted into the corresponding phosphines, which can be used as bulky, highly basic and air-stable ligands.
• Preparation of α-silyl- or α,α-bis(silyl)-substituted alkylcopper reagents and their synthetic use
  作者：Junichi Kondo、Atsushi Inoue、Yuki Ito、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1016/j.tet.2005.01.101

  日期：2005.3

  Treatment of chlorobis(methyldiphenylsilyl)methyllithium with various alkyl and aryl Grignard reagents and CuCN center dot 2LiCl afforded 1,1-disilylalkylcopper species. The aerobic oxidation of the resulting copper reagents provided a variety of acylsilanes in good yields. Meanwhile, treatment of dichloro(methyldiphenylsilyl)methyllithum with Bu2CuLi center dot LiCN provided 1-cyano-1-silylalkylcopper species via consecutive double 1,2-migration of alkyl and cyano groups. (c) 2005 Elsevier Ltd. All rights reserved.
• Facile Synthesis of Acylsilanes via Aerobic Oxidation of <i>g</i><i>em-</i>Disilylalkylcopper Compounds
  作者：Atsushi Inoue、Junichi Kondo、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1021/ja016716r

  日期：2001.11.1