hexadecyl urea | 2409-15-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: hexadecyl urea
• 英文别名: N-hexadecylurea；Hexadecyl-harnstoff；N-Hexadecylharnstoff；Cetylharnstoff；N-palmitylurea；Hexadecylurea
• CAS: 2409-15-6
• 化学式: C₁₇H₃₆N₂O
• 分子量: 284.486
• InChiKey: NKOHYPZTBAEGGO-UHFFFAOYSA-N

物化性质

• 熔点：
  108.5 °C
• 沸点：
  388.6±15.0 °C(Predicted)
• 密度：
  0.892±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  1

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  hexadecyl urea 在 乙醇 、 sodium 、 碳酸氢钠 作用下， 以 水 为溶剂， 反应 5.0h， 生成 sodium 5-(β-D-glucopyranosyl)-1-hexadecylbarbiturate
  参考文献：
  名称：

  两亲性β-C-糖基巴比妥酸盐的分级自组装成多反应性海藻酸盐样超分子水凝胶纤维和囊泡水凝胶

  摘要：

  巴比妥酸介导的Knoevenagel 缩合在未受保护的碳水化合物上使两亲性 β- C-糖基巴比妥酸盐作为水凝胶剂的分子设计成为可能。单尾糖亲分子自组装成藻酸盐样多刺激触发和响应的超分子水凝胶纤维。同时，双尾糖亲分子导致了囊泡水凝胶。巴比妥酸被证明是一种高效且多功能的化学工具箱，可用于获取和设计糖缀合物。

  DOI：

  10.1002/chem.202102950
• 作为产物：
  描述：

  十六胺 在 盐酸 作用下， 生成 hexadecyl urea
  参考文献：
  名称：

  Siddiqui, Salimuzzaman; Haider, S. Imtiaz; Ahmad, S. Salman, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1985, vol. 40, # 4, p. 546 - 549

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR TRAITER DES ÉTATS ASSOCIÉS À UNE ACTIVITÉ DE STING
  申请人：IFM DUE INC

  公开号：WO2020252240A1

  公开（公告）日：2020-12-17

  This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

  本公开涉及抑制（例如，拮抗）干扰素基因激活因子（STING）的化学实体（例如，化合物或药用可接受的盐，和/或水合物，和/或共晶，和/或化合物的药物组合）。所述化学实体是有用的，例如，用于治疗在受试者（例如，人）中增加（例如，过量）STING激活（例如，STING信号传导）有助于病理和/或症状和/或进展的状况、疾病或失调（例如，癌症）。本公开还涉及含有相同成分的药物组合物以及使用和制备相同成分的方法。
• INFRARED DYE FOR SILVER HALIDE-BASED PHOTOGRAPHIC ELEMENTS
  申请人：Zengerle Paul L.

  公开号：US20090234131A1

  公开（公告）日：2009-09-17

  A non-infrared sensitized low silver photographic element with a non-light sensitive layer, preferably an antihalation layer, containing a diphenylaminocyclopentene heptacyanine benzothiazolium infrared dye where the benzothiazolium groups have electron-withdrawing substituents on the phenyl ring and solubilzed alkyl groups on the nitrogen. The infrared dye can be present as a liquid-crystalline dispersion. This class of infrared dyes form J-aggregrated species in a liquid-crystalline or a solid particle dispersion with high IR density and low visible absorbance.

  一种非红外敏化低银光感光元件，具有非光敏感层，最好是一种含有二苯胺环戊烯七氰基苯并噻唑离子红外染料的抗光散层，其中苯并噻唑离子基团在苯环上具有电子吸引取代基，氮原子上具有可溶性烷基基团。红外染料可以以液晶分散形式存在。这类红外染料在液晶或固体颗粒分散体系中形成J-聚集物种，具有高红外密度和低可见吸收率。
• Azo coupling reactions of hydrophobic compounds
  申请人：Mineur Catherine

  公开号：US20060235227A1

  公开（公告）日：2006-10-19

  A process for forming a diazo compound comprises reacting an organic compound bearing an acidic hydrogen with an aryl-diazonium salt in the presence of an inorganic base and a non-halogenated solvent. The process is simpler and more environmentally friendly than known processes.

  形成重氮化合物的过程包括在无卤代溶剂存在下，将带有酸性氢的有机化合物与芳基重氮盐反应，在无机碱的存在下进行。该过程比已知的过程更简单和更环保。
• LIGHT EMITTING DEVICE CONTAINING PHOSPHORESCENT COMPLEX
  申请人：Ren Xiaofan

  公开号：US20080020237A1

  公开（公告）日：2008-01-24

  An OLED device comprises a cathode, an anode, and has therebetween a light emitting layer comprising a phosphorescent emitter represented by Formula (I): L n M   (I) wherein each L is a cyclometallated ligand with at least one containing a coumarin group, M is Ir or Pt, and n is 3 when M is Ir and 2 when M is Pt. The invention also comprised the compound of formula (I).

  一种OLED器件包括阴极、阳极，并且在两者之间具有一个发光层，该发光层包括由式(I)表示的磷光发射体：LnM  (I)其中每个L是至少含有一个香豆素基团的环金属配体，M是Ir或Pt，当M为Ir时，n为3，当M为Pt时，n为2。该发明还包括式(I)的化合物。
• Photographic yellow dye-forming couplers
  申请人：EASTMAN KODAK COMPANY

  公开号：EP1014186A1

  公开（公告）日：2000-06-28

  A photographic element comprises a light sensitive silver halide emulsion layer having associated therewith an open chain α-carbonyl acetanilide yellow dye-forming coupler having the formula: wherein R1 is selected from the group consisting of alkyl, aryl, heterocyclic, and amino groups, provided that R1 may form a ring bonded to another carbon atom which is a member of Ring "A"; each R2 is independently selected from the group consisting of those substituents having a Hammett's sigma value of 0 or less, and m is from 0 to 4; each R3 and R4 for each of the n carbon atoms is independently selected from the group consisting of hydrogen, alkoxy, aryl, heterocyclic, aryloxy, and alkyl groups, and n is 0 to 16; each R5 independently selected from the group consisting of amino, alkyl groups, and groups linked to the "B" ring by oxygen or sulfur, and p is 1 to 3, provided that two R5 groups may join to form a ring; R6 is selected from the group consisting of alkyl, aryl, and amino groups; each L is independently a divalent linking group and q is 0 to 3; and Ring "A" is bonded indirectly to the 3-, 4-, or 5-position of Ring "B"; and Z is hydrogen, or a group capable of coupling-off when the coupler reacts with an oxidized color developing agent.

  一种摄影元素包括具有与之相关联的开链α-酮基乙酰苯胺黄色染料生成偶联剂的感光性银卤化物乳胶层，其具有以下结构式：其中R1选自烷基、芳基、杂环基和氨基组成的群，前提是R1可能形成与另一个碳原子结合的环，该碳原子是“A”环的成员；每个R2独立地选自具有Hammett的sigma值为0或更低的取代基的群，m为0至4；每个R3和R4对于n个碳原子中的每个碳原子，独立地选自氢、烷氧基、芳基、杂环基、芳氧基和烷基组成的群，n为0至16；每个R5独立地选自氨基、烷基和通过氧或硫连接到“B”环的基团，p为1至3，前提是两个R5基团可以结合形成环；R6选自烷基、芳基和氨基组成的群；每个L独立地是二价连接基团，q为0至3；和“A”环间接连接到“B”环的3-、4-或5-位置；Z是氢，或者是在偶联剂与氧化的着色显影剂发生反应时能够偶联脱落的基团。