2,2,6,6-tetramethyl-1-(2,2,2-trifluoro-ethoxy)-piperidin-4-ol | 1110727-10-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,2,6,6-tetramethyl-1-(2,2,2-trifluoro-ethoxy)-piperidin-4-ol
• 英文别名: 2,2,6,6-Tetramethyl-1-(2,2,2-trifluoroethoxy)piperidin-4-ol
• CAS: 1110727-10-0
• 化学式: C₁₁H₂₀F₃NO₂
• 分子量: 255.281
• InChiKey: GNXUQVZAMWXCDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  阻聚剂701 、 3,3,3-三氟丙醛 在 双氧水 、 copper(l) chloride 作用下， 以 水 、 叔丁醇 为溶剂， 反应 72.0h， 以74%的产率得到2,2,6,6-tetramethyl-1-(2,2,2-trifluoro-ethoxy)-piperidin-4-ol
  参考文献：
  名称：

  Synthetic Studies on N-Alkoxyamines: A Mild and Broadly Applicable Route Starting from Nitroxide Radicals and Aldehydes

  摘要：

  A broad variety of 2,2,6,6-tetramethylpiperidine-based N-alkoxyamines were prepared in a newly found reaction. By means of a copper-catalyzed fragmentation reaction of aldehyde peroxides in the presence of TEMPO or TEMPO derivatives, N-alkoxyamines were obtained in moderate to good yields.

  DOI：

  10.1021/jo802403j

文献信息

• Synthetic Studies on <i>N</i>-Alkoxyamines: A Mild and Broadly Applicable Route Starting from Nitroxide Radicals and Aldehydes
  作者：Kai-Uwe Schoening、Walter Fischer、Stefan Hauck、Alexander Dichtl、Michael Kuepfert

  DOI：10.1021/jo802403j

  日期：2009.2.20

  A broad variety of 2,2,6,6-tetramethylpiperidine-based N-alkoxyamines were prepared in a newly found reaction. By means of a copper-catalyzed fragmentation reaction of aldehyde peroxides in the presence of TEMPO or TEMPO derivatives, N-alkoxyamines were obtained in moderate to good yields.