Brom-bis-<4-methoxy-phenyl>-phenyl-methan | 94867-34-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Brom-bis-<4-methoxy-phenyl>-phenyl-methan
• 英文别名: Bis-(4-methoxy-phenyl)-phenyl-brommethan；Bromobis(p-methoxyphenyl)phenylmethane；1-[bromo-(4-methoxyphenyl)-phenylmethyl]-4-methoxybenzene
• CAS: 94867-34-2
• 化学式: C₂₁H₁₉BrO₂
• 分子量: 383.285
• InChiKey: LAGAKCWZHOACJQ-UHFFFAOYSA-N

物化性质

• 沸点：
  463.8±45.0 °C(Predicted)
• 密度：
  1.303±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Brom-bis-<4-methoxy-phenyl>-phenyl-methan 在 偶氮二异丁腈 、 三正丁基氢锡 、 sodium cyanoborohydride 、 叔丁醇 作用下， 生成 4,4'-苄亚基二苯甲醚
  参考文献：
  名称：

  从反应混合物中除去有机锡残留物的实用方法。

  摘要：

  DOI：

  10.1021/jo960751c

文献信息

• Direct oxidation of the C(sp²)–C(sp³) bond from benzyltrimethylsilanes to phenols
  作者：Wei Li、Guolin Gao、Yuan Gao、Chao Yang、Wujiong Xia

  DOI：10.1039/c7cc01868a

  日期：——

  A novel pathway for direct conversion of benzylsilanes to phenols by oxidation with Na2S2O8 and oxygen is efficiently developed under mild and neutral conditions. The reaction shows good functional group tolerance to afford phenols in moderate yields. The possible mechanism is proposed based on the isotopic labeling trials.

  在温和和中性条件下，有效开发了通过用Na2S2O8和氧气氧化将苄基硅烷直接转化为苯酚的新途径。该反应显示出良好的官能团耐受性，以中等收率得到苯酚。根据同位素标记试验提出了可能的机制。
• Process for the preparation of substituted pyrrolidine neuraminidase inhibitors
  申请人：——

  公开号：US20030055297A1

  公开（公告）日：2003-03-20

  A process for the preparation of neuraminidase inhibitors having structural formula (28) 1 or therapeutically acceptable salts thereof, in which R 1 is alkyl, cycloalkyl, cycloalkylalkyl, or arylalkyl; R 2 is alkyl, cycloalkyl, cycloalkylalkyl, or arylalkyl; R 4 is alkyl, cycloalkyalkyl, or aryl-(C 2 -C 4 -alkyl); R 10 is methyl, ethyl, iso-propyl, or vinyl; and R 12 is hydrogen or alkyl and intermediates useful for the process are disclosed.

  一种用于制备具有结构式（28）1或其治疗上可接受的盐的神经氨酸酶抑制剂的方法，其中R1是烷基，环烷基，环烷基烷基或芳基烷基；R2是烷基，环烷基，环烷基烷基或芳基烷基；R4是烷基，环烷烷基或芳基（C2-C4-烷基）；R10是甲基，乙基，异丙基或乙烯基；和R12是氢或烷基，公开了用于该方法的中间体。
• Protected biotin derivatives
  申请人：ZENECA LIMITED

  公开号：EP0305201A2

  公开（公告）日：1989-03-01

  Processes for the preparation of biotinylated polynucleotides and analogues thereof and protected intermediate products for use in such processes are described and claimed. The processes may be conveniently used in the automated synthesis of biotinylated polynucleotide on a DNA synthesiser. The polynucleotides so prepared may be used as labelled probes e.g. as diagnostic tools for clinical and research uses.

  本发明描述并声称了制备生物素化多核苷酸及其类似物的工艺以及用于此类工艺的受保护中间产物。这些工艺可方便地用于在 DNA 合成器上自动合成生物素化多核苷酸。这样制备的多核苷酸可用作标记探针，如临床和研究用的诊断工具。
• Hybridization probe
  申请人：——

  公开号：US20040185459A1

  公开（公告）日：2004-09-23

  A probe is utilized in the hybridization with a natural nucleic acid to form a double strand. The probe contains a cytosine derivative which specifically binds to guanine by forming two hydrogen bonds with the guanine nucleotide and/or a guanine derivative which specifically binds to cytosine by forming two hydrogen bonds with the cytosine nucleotide. This enables a large number of hybridization reactions to be carried out at once under uniform conditions.

  探针用于与天然核酸杂交以形成双链。探针含有一种胞嘧啶衍生物，它通过与鸟嘌呤核苷酸形成两个氢键而与鸟嘌呤特异性结合，和/或含有一种鸟嘌呤衍生物，它通过与胞嘧啶核苷酸形成两个氢键而与胞嘧啶特异性结合。这样就能在统一条件下同时进行大量杂交反应。
• Arbuzov,A.E.; Tszin-Lin,C., Doklady Chemistry, 1962, vol. 144, p. 514 - 516
  作者：Arbuzov,A.E.、Tszin-Lin,C.

  DOI：——

  日期：——