Diethyl[3-(piperidin-4-yl)propyl]amine | 127425-06-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Diethyl[3-(piperidin-4-yl)propyl]amine
• 英文别名: N,N-diethyl-3-piperidin-4-ylpropan-1-amine
• CAS: 127425-06-3
• 化学式: C₁₂H₂₆N₂
• mdl: MFCD16693184
• 分子量: 198.352
• InChiKey: LDMFKPVKXQXQOR-UHFFFAOYSA-N

物化性质

• 沸点：
  252.5±8.0 °C(Predicted)
• 密度：
  0.862±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Diethyl[3-(piperidin-4-yl)propyl]amine 在 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 72.0h， 生成
  参考文献：
  名称：

  Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity

  摘要：

  The synthesis and preliminary pharmacological profile of a new series of muscarinic antagonists, derived from previously studied 2,2-diphenyl-2-ethylthio-acetic acid esters, are reported. The parent molecules were decorated with linkers of different length, carrying an amino group to catch a putative anionic function outside the recognition site of the receptor. It was hoped that the interception of this function would give molecules with higher potency and selectivity. The attempt has not been successful, but a new series of compounds with a peculiar pharmacological profile has been identified.

  DOI：

  10.1016/j.farmac.2004.08.003
• 作为产物：
  描述：

  3-(吡啶-4-基)-1-二乙氨基丙烷 在 platinum(IV) oxide 盐酸 、 氢气 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 Diethyl[3-(piperidin-4-yl)propyl]amine
  参考文献：
  名称：

  Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity

  摘要：

  The synthesis and preliminary pharmacological profile of a new series of muscarinic antagonists, derived from previously studied 2,2-diphenyl-2-ethylthio-acetic acid esters, are reported. The parent molecules were decorated with linkers of different length, carrying an amino group to catch a putative anionic function outside the recognition site of the receptor. It was hoped that the interception of this function would give molecules with higher potency and selectivity. The attempt has not been successful, but a new series of compounds with a peculiar pharmacological profile has been identified.

  DOI：

  10.1016/j.farmac.2004.08.003

文献信息

• Kondensierte Diazepinone, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
  申请人：Dr. Karl Thomae GmbH

  公开号：EP0312895A2

  公开（公告）日：1989-04-26

  Beschrieben werden neue kondensierte Diazepinone der allgemeinen Formel I in der Ⓑ einen der zweiwertigen Reste darstellt mit den in Anspruch 1 genannten Bedeutungen für die Reste A, X, Z, R1, R2 und R4 bis R8, desweiteren ihre Salze mit anorganischen oder organischen Säuren und Verfahren zu ihrer Herstellung. Die Verbindungen zeigen günstige Effekte auf die Herzfrequenz und sind angesichts fehlender magensäuresekretionshemmender, salivationshemmender und mydriatischer Einflüsse als vagale Schrittmacher zur Behandlung von Bradycardien und Bradyarrhythmien in der Human-und Veterinärmedizin geeignet.

  通式 I 的新缩合二氮杂卓酮 中的 的一个二价基中 二价基 A、X、Z、R1、R2 和 R4 至 R8 的含义如权利要求 1 所述。这些化合物显示出对心率的有利影响，并且在没有胃酸分泌抑制、唾液分泌抑制和眼球震颤影响的情况下，适合作为迷走神经起搏器用于治疗人类和兽医的心动过缓和缓慢性心律失常。
• Cohen, Victor I.; Jin, Biyun; Reba, Richard C., Liebigs Annalen der Chemie, 1993, # 7, p. 809 - 810
  作者：Cohen, Victor I.、Jin, Biyun、Reba, Richard C.

  DOI：——

  日期：——
• US5175158A
  申请人：——

  公开号：US5175158A

  公开（公告）日：1992-12-29
• Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity
  作者：Serena Scapecchi、Elisabetta Martini、Cristina Bellucci、Michela Buccioni、Silvia Dei、Luca Guandalini、Dina Manetti、Cecilia Martelli、Gabriella Marucci、Rosanna Matucci

  DOI：10.1016/j.farmac.2004.08.003

  日期：2004.12

  The synthesis and preliminary pharmacological profile of a new series of muscarinic antagonists, derived from previously studied 2,2-diphenyl-2-ethylthio-acetic acid esters, are reported. The parent molecules were decorated with linkers of different length, carrying an amino group to catch a putative anionic function outside the recognition site of the receptor. It was hoped that the interception of this function would give molecules with higher potency and selectivity. The attempt has not been successful, but a new series of compounds with a peculiar pharmacological profile has been identified.