N-(β-Vinyloxyethyl)piperidin | 702-06-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(β-Vinyloxyethyl)piperidin
• 英文别名: 1-(2-Vinyloxyethyl)piperidine；1-(2-ethenoxyethyl)piperidine
• CAS: 702-06-7
• 化学式: C₉H₁₇NO
• mdl: MFCD00047480
• 分子量: 155.24
• InChiKey: KQAQJORNWGFUKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(β-Vinyloxyethyl)piperidin 在 溴 作用下， 以 四氯化碳 为溶剂， 反应 0.5h， 以69%的产率得到1-bromomethyl-2-oxa-5-azoniaspiro[4.5]decane bromide
  参考文献：
  名称：

  Synthesis of a new heterocyclic system, 1-halomethyl-2-oxa-5-azoniaspiro[4.5]decane halides

  摘要：

  1-Halomethyl-2-oxa-5-azoniaspiro[4.5]decane halides were synthesized by reaction of 1-(2-vinyloxy)ethylpiperidine with bromine and iodine. The product structure was confirmed by H-1 NMR and IR spectroscopy, and their steric configuration was optimized in terms of the density functional theory.

  DOI：

  10.1134/s1070428011030237
• 作为产物：
  描述：

  哌啶 、 2-氯乙基乙烯基醚 在 水 、 碳酸氢钠 作用下， 生成 N-(β-Vinyloxyethyl)piperidin
  参考文献：
  名称：

  Preparation and Polymerization of Unsaturated Quaternary Ammonium Compounds. III. Vinyloxyethyl Derivatives^1,2

  摘要：

  DOI：

  10.1021/ja01128a020

文献信息

• PACKAGING SOLUTIONS
  申请人：Schorzman Derek A.

  公开号：US20080152540A1

  公开（公告）日：2008-06-26

  The present invention is directed to new and improved packaging systems for storing cationic ophthalmic devices such as cationic contact lenses and to methods for packaging such cationic ophthalmic devices with solutions to improve the comfort of the lenses during wear. In particular, the present invention is directed to a packaging system for storing a cationic ophthalmic device in a solution comprising an effective amount of an anionic polymer. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.

  本发明涉及新的和改进的包装系统，用于存储阳离子眼科设备，例如阳离子隐形眼镜，并提供包装这些阳离子眼科设备的方法，以改善佩戴隐形眼镜时的舒适度。具体而言，本发明涉及一种包装系统，用于在包含一定量阴离子聚合物的溶液中存储阳离子眼科设备。这样的溶液可以在未使用的镜片表面保留很长时间，从而导致在眼中持续存在的表面修饰，可能在首次使用的新镜片的润湿性能方面提供显着改善，而且甚至在镜片插入后数小时，也能防止干燥并提高润滑性。
• Balanced charge polymer and hydrophilic contact lens manufactured therefrom
  申请人：Hydron Limited

  公开号：EP0751404A2

  公开（公告）日：1997-01-02

  A water swellable crosslinked polymer of essentially balanced charge is obtained by polymerizing a polymer-forming composition comprising a cationic-anionic pair of ethylenically unsaturated monomers and a non-ionic ethylenically unsaturated hydrophillic and/or hydrophobic monomer. Contact lenses formed from the polymer exhibit little if any tendency to attract soils, eg proteinaceous debris, to their surfaces.

  通过聚合由一对阳离子-阴离子乙烯基不饱和单体和一种非离子乙烯基不饱和亲水和/或疏水单体组成的聚合物形成组合物，可获得电荷基本平衡的可遇水膨胀的交联聚合物。用这种聚合物制成的隐形眼镜表面几乎不会吸附污物（如蛋白质碎屑）。
• High water content silicone hydrogels
  申请人：Bausch & Lomb Incorporated

  公开号：EP2397505A1

  公开（公告）日：2011-12-21

  Silicone hydrogels formed from a hydrated polymerization product of a monomer mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; and (b) a minor amount of a silicone-containing monomer, wherein the hydrogel has a water content of greater than 50 weight percent are disclosed.

  公开了由单体混合物的水合聚合产物形成的有机硅水凝胶，该单体混合物包括(a)大量的非含硅亲水单体；和(b)少量的含硅单体，其中水凝胶的含水量大于 50%。
• Contact lens
  申请人：——

  公开号：US20020107337A1

  公开（公告）日：2002-08-08

  This invention is directed to ophthalmic materials and ophthalmic lenses that are a co-polymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group-containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer, as well as optional monomers or monomer mixtures that can include a cationic monomer, a non-aromatic hydrophobic monomer and a poly(dimethylsiloxy)silyl group-containing monomer. A contact lens prepared from such a co-polymer exhibits enhanced water content, while maintaining exceptional oxygen permeability, thereby providing a lens that can be worn comfortably for prolonged periods of time. A process for the preparation of such lenses is also disclosed.

  本发明涉及眼科材料和眼科镜片，它们是(a)亲水单体与(b)含三(硅氧)硅基单体的共聚产物、(c) 多种疏水单体（脂肪族和芳香族），通常还有 (d) 多氟单体，以及可选的单体或单体混合物，其中可包括阳离子单体、非芳香族疏水单体和含聚（二甲基硅氧）硅烷基团的单体。用这种共聚物制备的隐形眼镜含水量更高，同时还能保持优异的透氧性，从而提供一种可长时间舒适配戴的镜片。此外，还公开了制备这种镜片的工艺。
• Ophthalmic lenses and compositions and methods for producing same
  申请人：Ocular Sciences, Inc.

  公开号：US20020091175A1

  公开（公告）日：2002-07-11

  Ophthalmic lenses, such as corneal contact lenses, include a lens body made of a composition including a lens body made of a composition including a first crosslinked polymer material which is water swellable, and a second polymeric material, other than the first material, selected from water soluble polymeric materials, water swellable polymeric materials and mixtures thereof. The second material is physically immobilized by the first material. Such lenses provide increased water retention and/or increased water content and/or increased modulus and/or reduced friction which increases lens wearer comfort. Compositions and methods for providing such lenses and compositions are also provided.

  眼科镜片，如角膜接触镜，包括由一种组合物制成的镜片体，该组合物包括可在水中溶胀的第一交联聚合物材料，以及除第一种材料之外的第二种聚合物材料，第二种聚合物材料选自水溶性聚合物材料、可在水中溶胀的聚合物材料及其混合物。第二种材料被第一种材料物理固定。这种镜片可增加保水性和/或增加含水量和/或增加模量和/或减少摩擦，从而提高镜片佩戴者的舒适度。还提供了提供这种镜片和组合物的组合物和方法。