2-Hydroxy-1-methylsulfin-dodecan | 7322-10-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 英文名称: 2-Hydroxy-1-methylsulfin-dodecan
• 英文别名: 1-methanesulfinyl-dodecan-2-ol；1-Methylsulfinyldodecan-2-ol
• CAS: 7322-10-3
• 化学式: C₁₃H₂₈O₂S
• 分子量: 248.43
• InChiKey: CFJOZYXEPAHNRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  56.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Hydroxy-1-methylsulfin-dodecan 在 potassium tert-butylate 作用下， 以 叔丁醇 为溶剂， 生成 1-Methyl-sulfinyl-dodecen-(2)
  参考文献：
  名称：

  The Relation of Proton Exchange to Tautomerism in Unsaturated Sulfoxides

  摘要：

  DOI：

  10.1021/ja01065a033
• 作为产物：
  描述：

  1,2-环氧十二烷 、 甲硫醇 生成 2-Hydroxy-1-methylsulfin-dodecan
  参考文献：
  名称：

  The Relation of Proton Exchange to Tautomerism in Unsaturated Sulfoxides

  摘要：

  DOI：

  10.1021/ja01065a033

文献信息

• [EN] THERAPEUTIC PHENETHYLAMINE COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS DE PHÉNÉTHYLAMINE THÉRAPEUTIQUE ET MÉTHODES D'UTILISATION
  申请人：CYBIN IRL LTD

  公开号：WO2022038170A1

  公开（公告）日：2022-02-24

  There are disclosed deuterated 2C-X phenethylamine compounds, the use of such compounds in the treatment of diseases associated with a serotonin 5-HT2 receptor, pharmaceutical compositions such as tablet compositions and kits containing the compounds, methods of delivering the compounds in a mist via inhalation, and methods of treating diseases or disorders associated with a serotonin 5-HT2 receptor, such as central nervous system (CNS) disorders or psychological disorders with the compounds of the invention.

  本文披露了脱氘化的2C-X苯乙胺化合物，以及这些化合物在治疗与5-HT2受体相关的疾病中的应用，包括药用组合物（如片剂组合物）和包含这些化合物的套装，通过雾化吸入途径传递这些化合物的方法，以及使用本发明的化合物治疗与5-HT2受体相关的疾病或疾病的方法，如中枢神经系统（CNS）疾病或心理疾病。
• Detergent bleach compositions
  申请人：UNILEVER N.V.

  公开号：EP0037146A1

  公开（公告）日：1981-10-07

  A solid detergent bleach composition adapted for use at substantially any washing temperature, comprising essentially a detergent active compound and a synergistic mixture of a solid organic peroxy acid compound e.g. diperoxyazelaic acid, an inorganic peroxy compound e.g. sodium perborate and a stabilising sequestering agent. The composition which is preferably presented in the form of a particulate product, shows improved bleaching effect at substantially all washing temperatures. It has also advantages over compositions comprising bleaching activators in that it does not suffer from problems of in situ peroxy acid generation.

  一种适用于任何洗涤温度的固体洗涤漂白剂组合物，主要包括一种洗涤活性化合物和一种固体有机过氧化合物（如二脱氧壬二酸）、一种无机过氧化合物（如过硼酸钠）和一种稳定螯合剂的协同混合物。这种组合物最好以颗粒产品的形式出现，在几乎所有的洗涤温度下都能显示出更好的漂白效果。与含有漂白活化剂的组合物相比，它的优点还在于不会出现过氧酸原位生成的问题。
• Peroxyacid bleach composition and its use in detergent compositions
  申请人：UNILEVER N.V.

  公开号：EP0256443A2

  公开（公告）日：1988-02-24

  A stable, dry, granular peroxyacid bleach composition having particle size of from 500-2000 µm is disclosed, said composition comprising from 20 to 65% by weight of a solid organic peroxyacid compound, 79.5 to 30% by weight of at least one inert inorganic salt, and from 0.5 to about 6.5% by weight of a non-­oxidisable, acidic, polymeric builder. Low to medium temperature bleach detergent compositions comprising a surface-active agent, a detergency builder and said dry granular peroxyacid bleach composition are also disclosed.

  本发明公开了一种粒径为 500-2000 微米的稳定、干燥、颗粒状过氧酸漂白剂组合物，所述组合物包括 20% 至 65% （按重量计）的固体有机过氧酸化合物、79.5% 至 30% （按重量计）的至少一种惰性无机盐，以及 0.5% 至约 6.5% （按重量计）的不可氧化、酸性聚合物增效剂。 本发明还公开了由表面活性剂、增效剂和所述干燥颗粒状过氧酸漂白剂组合物组成的中低温漂白洗涤剂组合物。
• Transdermal delivery of dobutamine
  申请人：ELI LILLY AND COMPANY

  公开号：EP0492930A2

  公开（公告）日：1992-07-01

  The present invention provides a method for treating cardiac insufficiency in a warm-blooded animal comprising administering dobutamine transdermally, and formulations suitable therefor.

  本发明提供了一种治疗温血动物心功能不全的方法，包括透皮给药多巴酚丁胺和适用于该方法的制剂。
• Transdermal cannabinoid formulations
  申请人：MM Technology Holdings, LLC

  公开号：US10028904B2

  公开（公告）日：2018-07-24

  The present invention includes a transdermal composition which contains a pharmaceutically effective amount of a cannabinoid for delivery of the cannabinoid to the bloodstream of a user. The composition may comprise the following components: a surfactant-lecithin organogel; and a cannabinoid. The composition may also comprise an exogenous terpene. The cannabinoid is capable of diffusing from the composition into the bloodstream of the user, and may be used in methods for treating a patient suffering from a condition such as pain, nausea and emesis, convulsions, muscle spasm, inflammation, depression, and cachexia.

  本发明包括一种透皮组合物，其中含有药用有效量的大麻素，用于将大麻素输送到使用者的血液中。该组合物可包含以下成分：表面活性剂-卵磷脂有机凝胶；大麻素。组合物还可包括一种外源性萜烯。大麻素能够从组合物扩散到使用者的血液中，可用于治疗疼痛、恶心和呕吐、抽搐、肌肉痉挛、炎症、抑郁和恶病质等症状的患者。