1,2,6-tritertbutyl-3-carbethoxypiperidin-4-one | 1352788-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1,2,6-tritertbutyl-3-carbethoxypiperidin-4-one
• 英文别名: Ethyl 1,2,6-tritert-butyl-4-oxopiperidine-3-carboxylate；ethyl 1,2,6-tritert-butyl-4-oxopiperidine-3-carboxylate
• CAS: 1352788-87-4
• 化学式: C₂₀H₃₇NO₃
• 分子量: 339.519
• InChiKey: KPYFKVPHCLOTGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙酰乙酸乙酯 在 ammonium acetate 、 potassium carbonate 作用下， 以 乙醇 、 丙酮 为溶剂， 反应 15.0h， 生成 1,2,6-tritertbutyl-3-carbethoxypiperidin-4-one
  参考文献：
  名称：

  Synthesis and antimicrobial screening of novel 2,6-ditertiarybutylpiperidin-4-ones

  摘要：

  A new series of 2,6-ditertiarybutyl 4-piperidones were prepared from an aliphatic aldehyde not having an alpha hydrogen atom and their structures were confirmed by elemental and spectral data. These compounds were screened for antibacterial (Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia) and antifungal (Aspergillus niger and Trichoderma sp.) activities and found to be potentially active against bacteria and fungi.

  DOI：

  10.1007/s00044-011-9913-9

文献信息

• Synthesis and antimicrobial screening of novel 2,6-ditertiarybutylpiperidin-4-ones
  作者：C. Govindaraju、R. Valliappan、V. Sundari

  DOI：10.1007/s00044-011-9913-9

  日期：2012.11

  A new series of 2,6-ditertiarybutyl 4-piperidones were prepared from an aliphatic aldehyde not having an alpha hydrogen atom and their structures were confirmed by elemental and spectral data. These compounds were screened for antibacterial (Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia) and antifungal (Aspergillus niger and Trichoderma sp.) activities and found to be potentially active against bacteria and fungi.