tert-butyl((4-chlorobut-2-yn-1-yl)oxy)dimethylsilane | 93915-20-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tert-butyl((4-chlorobut-2-yn-1-yl)oxy)dimethylsilane
• 英文别名: (4-chlorobut-2-ynyloxy)(tert-butyl)dimethylsilane；Tert-butyl(4-chloro-but-2-ynyloxy)-dimethylsilane；tert-butyl-(4-chlorobut-2-ynoxy)-dimethylsilane
• CAS: 93915-20-9
• 化学式: C₁₀H₁₉ClOSi
• 分子量: 218.799
• InChiKey: WNFNQKROUYYNSB-UHFFFAOYSA-N

物化性质

• 沸点：
  231.7±20.0 °C(Predicted)
• 密度：
  0.949±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.25
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tert-butyl((4-chlorobut-2-yn-1-yl)oxy)dimethylsilane 在 三乙胺 、 lithium hydroxide 作用下， 以 二苯醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 生成 C₂₃H₃₀ClNO₂Si
  参考文献：
  名称：

  Synthesis of isoindolinones via inverse-electron demand Diels–Alder cycloadditions

  摘要：

  A new synthetic method has been developed for the synthesis of 2,4,5-substituted isoindolinones by means of intramolecular inverse-electron demand Diels-Alder cycloaddition reactions of substituted pyridazines. By taking advantage of the inherent reactivity of an intermediate chloropyridazine, a diverse set of analogues were prepared from common reagents and intermediates. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.02.093
• 作为产物：
  描述：

  4-(tert-butyldimethylsilyloxy)-2-butyn-1-ol 在 四溴化碳 、 三苯基膦 作用下， 以 乙醚 为溶剂， 反应 4.0h， 以38%的产率得到tert-butyl((4-chlorobut-2-yn-1-yl)oxy)dimethylsilane
  参考文献：
  名称：

  [EN] NOVEL NON-SYSTEMIC TGR5 AGONISTS
  [FR] NOUVEAUX AGONISTES DE TGR5 NON SYSTÉMIQUES

  摘要：

  公开号：

  WO2018005794A3

文献信息

• N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS
  申请人：Chambon Sandrine

  公开号：US20120178934A1

  公开（公告）日：2012-07-12

  The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I), and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.

  本发明涉及一种新型苯基-羧酰胺化合物，其结构对应于一般式(I)，以及它们的合成方法和它们在用于人类或兽医药物组合物中的用途或者它们在化妆品组合物中的用途。
• N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors
  申请人：Chambon Sandrine

  公开号：US09115102B2

  公开（公告）日：2015-08-25

  The present invention relates to novel benzene-carboxamide compounds having a structure that corresponds to the general formula (I), and also to their method of synthesis and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or else to their use in cosmetic compositions.

  本发明涉及一种新型苯甲酰胺化合物，其结构对应于通式（I），以及它们的合成方法和它们在用于人类或兽医药物组合物中的用途，或者用于化妆品组合物中的用途。
• Deslongchamps, Pierre; Lamothe, Serge; Lin, Ho-Shen, Canadian Journal of Chemistry, 1987, vol. 65, p. 1298 - 1307
  作者：Deslongchamps, Pierre、Lamothe, Serge、Lin, Ho-Shen

  DOI：——

  日期：——
• Deslongchamps, Pierre; Lamothe, Serge; Lin, Ho-Shen, Canadian Journal of Chemistry, 1984, vol. 62, p. 2395 - 2398
  作者：Deslongchamps, Pierre、Lamothe, Serge、Lin, Ho-Shen

  DOI：——

  日期：——
• Ruthenium-Catalyzed Intramolecular Homo-Diels−Alder Reaction of Alkyne-Tethered Norbornadienes. An Entry to Fused Angular Triquinanes
  作者：Alphonse Tenaglia、Sylvain Gaillard

  DOI：10.1021/ol701463r

  日期：2007.8.1

  2-(Pent-4-ynyl)norbornadienes undergo an intramolecular [2 + 2 + 2] cycloaddition in the presence of (nbd)RuCl2(PPh3)(2) as a catalyst affording annelated deltacyclenes in good to excellent yields. The usefulness of the reaction is illustrated by the straighforward conversion of pentacyclene 2a into the angularly fused triquinane 19.