1-Pentylpiperazine hydrochloride | 878739-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-Pentylpiperazine hydrochloride
• 英文别名: 1-pentylpiperazine;hydrochloride
• CAS: 878739-46-9
• 化学式: C9H21ClN2
• 分子量: 192.73
• InChiKey: VBFREZADIGLAMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-萘乙腈 、 1-Pentylpiperazine hydrochloride 、 聚合甲醛 生成 alpha-(2-Naphthalenyl)-4-pentylpiperazinepropanenitrile
  参考文献：
  名称：

  N-(aminoalkyl)-substituted(N or C

  摘要：

  该公式化合物为N-(氨基烷基)-取代(N或C烷基)-芳基-4-(甲基磺酰氨基)苯甲酰胺，其中R为C1-C4直链烷基，R1、R2和R3中的一个为苯基或萘基，另外两个为氢，--NR4R5为二级或三级氨基基团，X和X1为氢或烷基，n为0或1，可用作抗心律失常药物，特别是作为I类/III类联合药物治疗心律失常。

  公开号：

  US04920116A1

文献信息

• [EN] 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS<br/>[FR] DÉRIVÉS 5-[(PIPÉRAZINE-1-YL) -3-OXO-PROPYL]-IMIDAZOLIDINE -2,4-DIONE COMME INHIBITEURS D'ADAMTS POUR LE TRAITEMENT DE L'ARTHROSE
  申请人：GALAPAGOS NV

  公开号：WO2016102347A1

  公开（公告）日：2016-06-30

  The present invention discloses compounds according to Formula (I), wherein R, R2, R3a, R3b, and Cy are as defined herein. The present invention discloses compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same and methods for the prophylaxis and/or treatment of inflammatory conditions and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis.

  本发明公开了根据式(I)的化合物，其中R、R2、R3a、R3b和Cy如本文所定义。本发明公开了抑制ADAMTS的化合物、其制备方法、包含该化合物的药物组合物以及用于预防和/或治疗涉及软骨降解和/或软骨稳态破坏的炎症状况和/或疾病的方法。
• Modulators or Alpha7 Nicotinic Acetylcholine Receptors and Therapeutic Uses Thereof
  申请人：Gaviraghi Giovanni

  公开号：US20080275028A1

  公开（公告）日：2008-11-06

  The present invention relates to compounds with α7 nAChR agonistic activity, processes for their preparation, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological, psychiatric, cognitive, immunological and inflammatory disorders.

  本发明涉及具有α7 nAChR激动活性的化合物，其制备方法，含有该化合物的制药组合物以及用于治疗神经、精神、认知、免疫和炎症性疾病的用途。
• 4-Aryl-N-[2-(dialkylamino and heterocyclicamino) alkyl]-1-piperazinecarboxamides and their use as anti allergy agents
  申请人：A.H. ROBINS COMPANY, INCORPORATED

  公开号：EP0277725A2

  公开（公告）日：1988-08-10

  Novel 4-aryl-N-[2-(dialkylamino and heterocyclic­amino)alkyl]-1-piperazinecarboxamides of the formula: wherein B is oxygen or sulfur; Ar is selected from Or 2, 3 or 4-pyridyl; X is selected from hydrogen, halogen, loweralkyl, loweralkoxy, amino, dimethylamino, nitro, trifluoromethyl, cyano, acetyl, acetylamino, aminocarbonyl, carboxy or loweralkylcarboxylic acid ester; Y is selected from hydrogen, halogen, loweralkyl, loweralkoxy, nitro, trifluoromethyl, cyano, acetylamino, aminocarbonyl, carboxy or loweralkyl carboxylic acid ester; Z is selected from hydrogen, loweralkyl or loweralkoxy; Q is selected from m is 1 to 3 inclusive; n is zero or 1; p is zero to 3 inclusive; R¹, R² and R³ are loweralkyl and may be the same or different, or R¹ and R² taken together with the adjacent nitrogen atom may form a heterocyclic residue; and the pharmaceutically acceptable salts thereof are disclosed. The compounds are useful in a method of combating allergic response associated with anaphylactic sensitivity in animals and humans.

  式中的新型 4-芳基-N-[2-(二烷基氨基和杂环氨基)烷基]-1-哌嗪甲酰胺： 其中 B 是氧或硫；Ar 选自 或2、3或4-吡啶基；X选自氢、卤素、低级烷基、低级烷氧基、氨基、二甲基氨基、硝基、三氟甲基、氰基、乙酰基、乙酰氨基、氨基羰基、羧基或低级烷基羧酸酯；Y 选自氢、卤素、低级烷基、低级烷氧基、硝基、三氟甲基、氰基、乙酰氨基、 氨基羰基、羧基或低级烷基羧酸酯； Z 选自氢、低级烷基或低级烷氧基； Q 选自 R¹、R²和R³为低级烷基，可以相同或不同，或者R¹和R²与相邻的氮原子一起可形成杂环残基；以及公开了其药学上可接受的盐。这些化合物可用于防治动物和人类与过敏反应相关的过敏反应。
• 5-[(piperazin-l-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis
  申请人：GALAPAGOS NV

  公开号：US10941117B2

  公开（公告）日：2021-03-09

  The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.

  本发明公开了符合式 I 的化合物： 其中R1、R2、R3a、R3b和Cy如本文所定义。 本发明涉及抑制 ADAMTS 的化合物、其生产方法、包含本发明化合物的药物组合物以及使用本发明化合物进行治疗的方法，通过施用本发明化合物来预防和/或治疗炎症和/或涉及软骨降解和/或破坏软骨稳态的疾病。
• AROMATIC KETO-ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0876343A1

  公开（公告）日：1998-11-11