1-Ethyl-2,5-dimethylpiperazine | 143526-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-Ethyl-2,5-dimethylpiperazine
• CAS: 143526-63-0
• 化学式: C₈H₁₈N₂
• mdl: MFCD18072988
• 分子量: 142.24
• InChiKey: QNTATFFRXJXEKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR
  申请人：Noble Stewart A.

  公开号：US20090264417A1

  公开（公告）日：2009-10-22

  Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.

  本发明公开了化合物作为过氧化物酶体增生物激活受体的调节剂，包含这些化合物的制药组合物以及使用它们治疗疾病的方法。
• REMEDY FOR DISEASES CAUSED BY INFECTION WITH HELICOBACTER
  申请人：KANEKA CORPORATION

  公开号：EP0787494A1

  公开（公告）日：1997-08-06

  A curative medicine for a digestive organ disease caused by the infection of Helicobacter comprising as an effective component a rifamycin derivative expressed by the formula (I) or the formula (II), or a physiologically acceptable salt thereof. In the formula (I), X1 represents an oxygen atom or a sulfur atom, R1 represents an acetyl group or a hydrogen atom, R2 represents a hydroxy group or a hydrogen atom, R3 represents [in which R4 and R5 are the same or different and each is an alkyl group having 1 to 3 carbon atoms or a group expressed by the formula (in which m represents an integer between 1 and 3)], or [in which R6 and R7 are the same or different and each is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, X2 represents an oxygen atom or a sulfur atom or NR8 R8 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms or -(CH2)nX3 (in which n represents an integer between 1 and 4, and X3 represents an alkoxy group having of 1 to 3 carbon atoms, or a vinyl group or an ethynyl group, or a group expressed by the formula In the formula (II), R9 represents an alkyl group having 1 to 7 carbon atoms.

  一种治疗由螺旋杆菌感染引起的消化器官疾病的药物，其有效成分包括由式（I）或式（II）表示的利福霉素衍生物，或其生理上可接受的盐。 在式 (I) 中，X1 代表氧原子或硫原子，R1 代表乙酰基或氢原子，R2 代表羟基或氢原子，R3 代表 [其中 R4 和 R5 相同或不同，且各为具有 1 至 3 个碳原子的烷基或由式表示的基团 (其中 m 代表 1 至 3 之间的整数）]，或 [其中 R6 和 R7 相同或不同，且各自为氢原子或具有 1 至 3 个碳原子的烷基，X2 代表氧原子或硫原子或 NR8 R8 代表氢原子或具有 1 至 6 个碳原子的烷基或-(CH2)nX3（其中 n 代表 1 至 4 之间的整数，X3 代表具有 1 至 3 个碳原子的烷氧基，或乙烯基或乙炔基，或由式表示的基团）]。 在式 (II) 中，R9 代表具有 1 至 7 个碳原子的烷基。
• Curative medicine for disease caused by infection of Helicobacter
  申请人：KANEKA CORPORATION

  公开号：EP0861660A1

  公开（公告）日：1998-09-02

  A curative medicine for a digestive organ disease caused by the infection of Helicobacter, comprising a rifamycin derivative expressed by the formula (I), or a physiologically acceptable salt thereof.

  一种治疗由螺旋杆菌感染引起的消化器官疾病的药物，包括由式（I）表示的利福霉素衍生物或其生理上可接受的盐。
• PROCESS FOR PRODUCTION OF POLYESTER-CONTAINING FLEXIBLE POLYURETHANE FOAM, AND CATALYST COMPOSITION FOR USE IN THE PROCESS
  申请人：Tosoh Corporation

  公开号：EP2204394A1

  公开（公告）日：2010-07-07

  To provide a method for producing a low-odor polyester-type flexible polyurethane foam which is excellent in formability and free from scorch in the interior of the foam, and further discharges substantially no volatile amine compound from a product, in the production of a polyester-type flexible polyurethane foam, and to provide a catalyst composition to be used for the production method. A polyester-type flexible polyurethane foam is produced by a process which comprises reacting a polyester polyol with a polyisocyanate, in the presence of a catalyst composition containing one or more amine compounds selected from the group consisting of an amine compound represented by the following formula (1): in the above formula (1), R1 is a C1-6 linear or branched alkyl group, and each of R2, R3, R4 and R5 which are independent of one another, is a hydrogen atom or a C1-2 alkyl group, an amine compound represented by the following formula (2): in the above formula (2), R6 is a C2-6 linear or branched alkylene group, and an amine compound represented by the following formula (3): in the above formula (3), each of R7 and R8 which are independent of each other, is a C1-4 alkyl group, and R9 is a C3-5 linear or branched alkylene group; a blowing agent; and a surfactant.

  提供一种生产低气味聚酯型软质聚氨酯泡沫塑料的方法，该泡沫塑料具有良好的成型性，泡沫塑料内部无焦烧现象，而且在生产聚酯型软质聚氨酯泡沫塑料时，产品中基本上不排放挥发性胺化合物，并提供一种用于该生产方法的催化剂组合物。 聚酯型软质聚氨酯泡沫塑料的生产工艺包括：在催化剂组合物存在的情况下，使聚酯多元醇与多异氰酸酯反应，催化剂组合物含有一种或多种胺化合物，这些胺化合物选自由下式(1)所代表的胺化合物组成的组： 在上式（1）中，R1 是 C1-6 直链或支链烷基，R2、R3、R4 和 R5 中的每一个彼此独立，是氢原子或 C1-2 烷基、 下式(2)所代表的胺化合物： 在上式（2）中，R6 是 C2-6 直链或支链亚烷基，以及下式（3）代表的胺化合物： 在上式（3）中，相互独立的 R7 和 R8 均为 C1-4 烷基，R9 为 C3-5 直链或支链亚烷基；发泡剂；以及表面活性剂。
• Use of rifamycin derivatives for the manufacture of a medicament for the treatment of diseases caused by infections of helicobacter pylori
  申请人：KANEKA CORPORATION

  公开号：EP0787494B1

  公开（公告）日：2004-06-09