triphenmethyl methyl sulfide | 62575-83-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: triphenmethyl methyl sulfide
• 英文别名: Ph3CSMe；methyl-trityl sulfide；Methyl-trityl-sulfid；α-Methylmercapto-triphenylmethan；Methyl-triphenylmethyl-sulfid；Benzene, 1,1',1''-[(methylthio)methylidyne]tris-；[methylsulfanyl(diphenyl)methyl]benzene
• CAS: 62575-83-1
• 化学式: C₂₀H₁₈S
• 分子量: 290.429
• InChiKey: WURAJSNODLQVDX-UHFFFAOYSA-N

物化性质

• 熔点：
  105 °C
• 沸点：
  395.2±11.0 °C(Predicted)
• 密度：
  1.103±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  triphenmethyl methyl sulfide 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以16%的产率得到triphenylmethyl methyl sulfoxide
  参考文献：
  名称：

  使用亚砜试剂对酰胺进行化学选择性 α-硫化

  摘要：

  描述了在亲电子酰胺活化条件下使用亚砜试剂对叔酰胺进行直接 α-硫化。使用方便且容易获得的试剂，进行选择性官能化以在生成 α-硫醚酰胺的过程中生成可分离的锍离子。机理研究确定活化的亚砜是所需转化的促进剂，并使该方法从苄基底物扩展到脂肪族酰胺底物。

  DOI：

  10.1021/acs.orglett.0c03160
• 作为产物：
  描述：

  三苯基氯甲烷 在 甲醇 、 氢氧化钾 、 硫化氢 、 sodium ethanolate 作用下， 生成 triphenmethyl methyl sulfide
  参考文献：
  名称：

  Vorlaender; Mittag, Chemische Berichte, 1913, vol. 46, p. 3453

  摘要：

  DOI：

文献信息

• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF (1S, 4S, 7Z, 10S, 16E, 21R)- 7-ETHYLIDENE-4,21-BIS(1-METHYLETHYL)-2-OXA-12,13-DITHIA-5, 8, 20, 23- TETRAAZABICYCLO[8.7.6]TRICOS-16-ENE-3, 6, 9, 19, 22-PENTONE<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE (1S, 4S, 7Z, 10S, 16E, 21R)- 7-ÉTHYLIDÈNE-4,21-BIS(1-MÉTHYLÉTHYL)-2-OXA-12,13-DITHIA-5, 8, 20, 23- TÉTRAAZABICYCLO[8.7.6]TRICOS-16-ÈNE-3, 6, 9, 19, 22-PENTONE
  申请人：MSN LABORATORIES PRIVATE LTD

  公开号：WO2017068596A1

  公开（公告）日：2017-04-27

  The present invention is relates to an improved process for the preparation (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabi-cyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone of formula I.

  本发明涉及一种改进的制备过程，用于制备式I的(1S,4S,7Z,10S,16E,21R)-7-乙烯基-4,21-双(1-甲基乙基)-2-氧-12,13-二硫-5,8,20,23-四氮杂环[8.7.6]三十一烯-16-烯-3,6,9,19,22-五酮。
• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF MACROMOLECULES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR L'APPORT DE MACROMOLÉCULES
  申请人：UNIV CALIFORNIA

  公开号：WO2019112965A1

  公开（公告）日：2019-06-13

  The present disclosure provides endosomal disruptors, which are useful for facilitating delivery of a macromolecule to the cytoplasm of a cell. The present disclosure provides compositions comprising an endosomal disruptor and a macromolecule. The present disclosure provides methods of delivering a macromolecule to the cytoplasm of a cell.

  本公开提供了一种内体破坏剂，可用于促进大分子向细胞质的传递。本公开提供了包含内体破坏剂和大分子的组合物。本公开提供了将大分子传递至细胞质的方法。
• Method for producing epoxide crystal
  申请人：Ajinomoto Co., Inc.

  公开号：US20020072621A1

  公开（公告）日：2002-06-13

  The invention relates to a method for industrially producing highly pure (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide (crystal) or (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoalcohol. The method for producing N-carbamate-protected &bgr;-aminoepoxide crystal, includes one or more of the following steps (a) to (d): (a) dissolving (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoalcohol containing at least the diastereomer as an impurity in a solvent including at least one or more selected from aromatic hydrocarbon solvent, saturated hydrocarbon solvent, aqueous mixture solvent, acetone and 2-propanol, to remove insoluble matters; (b) treating the (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoalcohol with a base, thereby converting the N-carbamate-protected &bgr;-aminoalcohol to (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide; (c) treating the (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide containing at least the diastereomer as an impurity with an acid, thereby converting the diastereomer as an impurity to (4S, 5R) or (4R, 5S) oxazolidin-2-one derivative, and optionally separating and removing the resulting oxazolidin-2-one derivative in water or an aqueous mixture solvent; and (d) crystallizing the (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide in a mixture solvent of water and water-miscible organic solvent. By the methods of the present invention, highly pure (2R, 3S)- or (2S, 3R)-N-carbamate-protected &bgr;-aminoepoxide or (2R, 3S) or (2S, 3R)-N-carbamate-protected &bgr;-aminoalcohol can be efficiently produced.

  该发明涉及一种工业生产高纯度(2R, 3S)或(2S, 3R)-N-碳酸酯保护的β-氨基环氧乙烷(晶体)或(2R, 3S)或(2S, 3R)-N-碳酸酯保护的β-氨基醇的方法。生产N-碳酸酯保护的β-氨基环氧乙烷晶体的方法包括以下一项或多项步骤(a)至(d)：(a)将至少含有对映异构体作为杂质的(2R, 3S)或(2S, 3R)-N-碳酸酯保护的β-氨基醇溶解于包括至少选择自芳香烃溶剂、饱和烃溶剂、水混合溶剂、丙酮和异丙醇的溶剂中，以去除不溶物质；(b)用碱处理(2R, 3S)或(2S, 3R)-N-碳酸酯保护的β-氨基醇，从而将N-碳酸酯保护的β-氨基醇转化为(2R, 3S)或(2S, 3R)-N-碳酸酯保护的β-氨基环氧乙烷；(c)用酸处理至少含有对映异构体作为杂质的(2R, 3S)或(2S, 3R)-N-碳酸酯保护的β-氨基环氧乙烷，从而将对映异构体作为杂质转化为(4S, 5R)或(4R, 5S)噁唑烷-2-酮衍生物，并可在水或水混合溶剂中分离和去除所得的噁唑烷-2-酮衍生物；(d)在水和水亲和性有机溶剂的混合溶剂中结晶(2R, 3S)或(2S, 3R)-N-碳酸酯保护的β-氨基环氧乙烷。通过本发明的方法，可以高效生产高纯度的(2R, 3S)或(2S, 3R)-N-碳酸酯保护的β-氨基环氧乙烷或(2R, 3S)或(2S, 3R)-N-碳酸酯保护的β-氨基醇。
• Production method of aminochlorohydrin sulfate
  申请人：Ajinomoto Co., Inc.

  公开号：EP1777213A1

  公开（公告）日：2007-04-25

  Highly pure (2R,3S)-3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane or (2S,3R)-3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane may be conveniently produced in high yield by: (a) reacting compound (1) with lithiumchloromethane to give compound (2) and at least a byproduct; (b) dissolving compound (2) and the byproduct in a polar solvent and adding water to the solution to precipitate compound (2) as crystals; (c) reducing the crystals of compound (2) to give compound (3) and at least its diastereomer as an impurity; (d) adding sulfuric acid thereto to give compound (4) and at least its diastereomer as an impurity; and (e) precipitating compound (4) as crystals from a solution containing acetic acid ester or acetic acid ester.

  (2R,3S)-3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane或(2S,3R)-3-tert-butoxycarbonylamino-1-chloro-2-hydroxy-4-phenylbutane可以通过以下步骤方便地高产率地制备：(a)将化合物(1)与氯甲基锂反应，得到化合物(2)和至少一种副产物；(b)将化合物(2)和副产物溶解在极性溶剂中，并向溶液中加入水，使化合物(2)以晶体形式沉淀出来；(c)将化合物(2)的晶体还原，得到化合物(3)和至少其对映异构体作为杂质；(d)加入硫酸至其中，得到化合物(4)和至少其对映异构体作为杂质；(e)从含有乙酸酯或乙酸酯的溶液中沉淀化合物(4)为晶体。
• Process for producing alpha-aminoketones
  申请人：AJINOMOTO CO., INC.

  公开号：US20020013499A1

  公开（公告）日：2002-01-31

  An amino group of an &agr;-amino acid ester is protected as an imine, and it is then reacted with a halomethyllithium to obtain an N-protected-&agr;-aminohalomethylketone. Further, this N-protected-&agr;-aminohalomethylketone is treated with an acid to obtain an &agr;-aminohalomethylketone. This process is suited for industrial production, and can produce an &agr;-aminohalomethylketone and its related compounds economically and efficiently.

  一个α-氨基酸酯的氨基团被保护为亚胺，然后与卤代甲基锂反应，得到一个N-保护的α-氨基卤代甲基酮。此外，这个N-保护的α-氨基卤代甲基酮经过酸处理，得到一个α-氨基卤代甲基酮。这个过程适用于工业生产，并且可以经济高效地生产α-氨基卤代甲基酮及其相关化合物。