3-(dimethyl(phenyl)silyl)propionyl chloride | 17983-34-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 3-(dimethyl(phenyl)silyl)propionyl chloride
• 英文别名: 3-[Dimethyl(phenyl)silyl]propanoyl chloride；3-[dimethyl(phenyl)silyl]propanoyl chloride
• CAS: 17983-34-5
• 化学式: C₁₁H₁₅ClOSi
• 分子量: 226.778
• InChiKey: KYOQFOSZYQOACD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.76
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(dimethyl(phenyl)silyl)propionyl chloride 在 吡啶 、 对甲苯磺酸 作用下， 以 甲醇 、 苯 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  Bruchins—Mitogenic 3-(Hydroxypropanoyl) Esters of Long Chain Diols from Weevils of the Bruchidae

  摘要：

  Mono- and bis 3-(hydroxypropanoyl) esters of long chain, unsaturated diols have been isolated and identified from two genera of the family Bruchidae, and have been shown to be responsible for the mitogenic activity observed on pea pods resulting from oviposition by the pea weevil, Bruchus pisorum. The mitogenic compounds have been characterized and synthesized. Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(00)00650-5
• 作为产物：
  描述：

  二甲基氯甲基苯基硅烷 在 SOCl₂ 作用下， 以 not given 为溶剂， 生成 3-(dimethyl(phenyl)silyl)propionyl chloride
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 25, page 77 - 79

  摘要：

  DOI：

文献信息

• Thermal [2 + 2]-Cycloaddition of Ketenes with Chiral Enol Ethers: Route to Densely Substituted Cyclobutanones
  作者：Pauline Rullière、Julien Grisel、Clément Poittevin、Pascale Cividino、Sébastien Carret、Jean-François Poisson

  DOI：10.1021/acs.orglett.6b01058

  日期：2016.6.17

  polysubstituted cyclobutanones by [2 + 2]-cycloaddition of ketenes with chiral acyclic enol ethers is reported. A wide variety of easily accessible di- and monosubstituted ketenes were found to react with a very high degree of stereoselectivity with chiral, Stericol derived, acyclic enol ethers. This combination of simple reagents provides straightforward entry to highly substituted enantioenriched

  据报道，乙烯酮与手性无环烯醇醚的[2 + 2]-环加成反应获得了手性多取代的环丁酮。发现各种易于获得的二取代和单取代的烯酮与手性，三羟甾醇衍生的无环烯醇醚以非常高的立体选择性反应。简单试剂的这种组合提供了直接进入高度取代的对映体富集的环丁酮的途径。
• New Silicon-Containing Esters, Acids, Ketones, Alcohols and Halides. Acetoacetic Ester Syntheses with Organosilicon Compounds¹
  作者：Leo H. Sommer、Nelson S. Marans

  DOI：10.1021/ja01161a021

  日期：1950.5
• Bruchins—Mitogenic 3-(Hydroxypropanoyl) Esters of Long Chain Diols from Weevils of the Bruchidae
  作者：James E Oliver、Robert P Doss、R.Thomas Williamson、John R Carney、E.David DeVilbiss

  DOI：10.1016/s0040-4020(00)00650-5

  日期：2000.9

  Mono- and bis 3-(hydroxypropanoyl) esters of long chain, unsaturated diols have been isolated and identified from two genera of the family Bruchidae, and have been shown to be responsible for the mitogenic activity observed on pea pods resulting from oviposition by the pea weevil, Bruchus pisorum. The mitogenic compounds have been characterized and synthesized. Published by Elsevier Science Ltd.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 25, page 77 - 79
  作者：

  DOI：——

  日期：——